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Proceedings, 2025, LISSSD 2025

The 22nd Lancefield International Symposium on Streptococci and Streptococcal Diseases (LISSSD 2025)

Brisbane, Australia | 1–5 June 2025

Volume Editors:
Manisha Pandey, Griffith University, Australia
Michael F. Good, Griffith University, Australia
Joshua Osowicki, Murdoch Children's Research Institute, Australia
Theresa Lamagni, UK Health Security Agency, UK

Associate Editors:
Victoria Ozberk, Griffith University, Australia
Ailin Lepletier, Griffith University, Australia

Number of Papers: 28
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Cover Story (view full-size image): The 22nd Lancefield International Symposium on Streptococci and Streptococcal Diseases (LISSSD 2025) was held on 1–5 June 2025 in Brisbane, Australia. LISSSD 2025 was co-chaired by Assoc Prof [...] Read more.
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Research

2 pages, 119 KB  
Abstract
Models of Vaccine Finance and Their Potential Application to Group A Streptococcus Vaccines
by Daniel Tortorice and David E. Bloom
Proceedings 2025, 124(1), 1; https://doi.org/10.3390/proceedings2025124001 - 4 Aug 2025
Viewed by 403
Abstract
Background: Group A Streptococcus (GAS) leads to an estimated 600,000 deaths and 600 million cases of pharyngitis per year [...] Full article
(This article belongs to the Proceedings of The 22nd Lancefield International Symposium on Streptococci and Streptococcal Diseases (LISSSD 2025))
2 pages, 134 KB  
Abstract
How to Utilize a Genome-Scale Metabolic Model and iModulon in the Research of Streptococcus pyogenes M1 Serotype
by Yujiro Hirose, Eri Ikeda, Masayuki Ono, Masaya Yamaguchi, Bernhard O. Palsson and Victor Nizet
Proceedings 2025, 124(1), 2; https://doi.org/10.3390/proceedings2025124002 - 6 Aug 2025
Viewed by 420
Abstract
Streptococcus pyogenes can cause a wide variety of acute infections throughout the body of its human host [...] Full article
(This article belongs to the Proceedings of The 22nd Lancefield International Symposium on Streptococci and Streptococcal Diseases (LISSSD 2025))
2 pages, 134 KB  
Abstract
A Clinically Relevant Cationic Adjuvant System Induces Th17 T Cells Involved in Skin and Upper Airway Infections with Streptococcus pyogenes
by Kristoffer Mazanti Melchiors, Nina Dieu Nhien Tran Nguyen, Sharmila Subratheepam, Ida Rosenkrands, Frank Follmann and Jes Dietrich
Proceedings 2025, 124(1), 3; https://doi.org/10.3390/proceedings2025124003 - 6 Aug 2025
Viewed by 312
Abstract
Streptococcus pyogenes (Group A Streptococcus, StrepA) is a human pathogen responsible for hundreds of millions of infections each year and remains one of the most prevalent bacterial causes of upper respiratory and skin infections worldwide [...] Full article
(This article belongs to the Proceedings of The 22nd Lancefield International Symposium on Streptococci and Streptococcal Diseases (LISSSD 2025))
2 pages, 128 KB  
Abstract
Invasive Group A Streptococcus and Respiratory Viral Coinfections in Alberta, Canada, from 2018 to 2024
by Skyler Ngo, Alexa Thompson and Gregory J. Tyrrell
Proceedings 2025, 124(1), 4; https://doi.org/10.3390/proceedings2025124004 - 6 Aug 2025
Viewed by 320
Abstract
Intro: The epidemiology of invasive group A Streptococcus (iGAS) has been previously documented in Alberta, Canada; however, the role coinfections with respiratory viral infections (VRIs) play with associated emm types remains unclear [...] Full article
(This article belongs to the Proceedings of The 22nd Lancefield International Symposium on Streptococci and Streptococcal Diseases (LISSSD 2025))
2 pages, 109 KB  
Abstract
The Emerging Role of Biomarker-Driven Diagnostics in Post-Streptococcal Glomerulonephritis
by Tawakaltu Abdulrasheed-Adeleke, Muhammad Haruna Garba and Aliyu Evuti Haruna
Proceedings 2025, 124(1), 5; https://doi.org/10.3390/proceedings2025124005 - 6 Aug 2025
Viewed by 338
Abstract
Post-streptococcal glomerulonephritis (PSGN) is an immune-mediated kidney disease that occurs after infection with Streptococcus pyogenes (Group A Streptococcus, GAS) [...] Full article
(This article belongs to the Proceedings of The 22nd Lancefield International Symposium on Streptococci and Streptococcal Diseases (LISSSD 2025))
2 pages, 115 KB  
Abstract
A Molecular Epidemiology of Invasive Group A Streptococcus (iGAS) Infection Detected Within the Hunter New England Local Health District (HNELHD) of New South Wales (NSW), Australia from 2007 to 2017
by Pappu K. Mandal, Trent A. J. Butler, Emily Green, Kirsten M. Williamson, Sebastiaan Van Hal and Hemalatha Varadhan
Proceedings 2025, 124(1), 6; https://doi.org/10.3390/proceedings2025124006 - 7 Aug 2025
Viewed by 339
Abstract
Invasive Group A Streptococcal infection (iGAS) is an uncommon but serious infection with reported case fatality rates of up to 15% [...] Full article
(This article belongs to the Proceedings of The 22nd Lancefield International Symposium on Streptococci and Streptococcal Diseases (LISSSD 2025))
2 pages, 119 KB  
Abstract
Addressing Rheumatic Heart Disease in the Pacific
by Joseph H. Kado, Jessica N. Daw, Christine Everest and Rosemary Wyber
Proceedings 2025, 124(1), 7; https://doi.org/10.3390/proceedings2025124007 - 12 Aug 2025
Viewed by 319
Abstract
Background/Purpose: Pacific leaders have articulated addressing rheumatic heart disease (RHD) as a Pacific health priority [...] Full article
(This article belongs to the Proceedings of The 22nd Lancefield International Symposium on Streptococci and Streptococcal Diseases (LISSSD 2025))
2 pages, 131 KB  
Abstract
Parenteral Vaccination with a Super Immunogen Targeting M-Protein Provides Unprecedented Protection Against Group A Streptococcus (StrepA) Respiratory Infections
by Victoria Ozberk, Christie Short, Ailin Lepletier, Ainslie Calcutt, Khushi Jain, Simone Reynolds, Aroon Supramaniam, Jamie-lee Mills, Jessica Dooley, Jacqualine Kaden, Michael F. Good and Manisha Pandey
Proceedings 2025, 124(1), 8; https://doi.org/10.3390/proceedings2025124008 - 8 Aug 2025
Viewed by 397
Abstract
Rheumatic heart disease (RHD) is a devastating consequence of group A streptococcus (StrepA) infections, being associated with 15 [...] Full article
(This article belongs to the Proceedings of The 22nd Lancefield International Symposium on Streptococci and Streptococcal Diseases (LISSSD 2025))
2 pages, 127 KB  
Abstract
Whole-Genome Sequencing Reveals the Genetic Divergence of the emm1-2 Genotype Prevalent in India from the Globally Prevalent emm1, Supporting Its Classification as a Distinct Genotype
by Vivek Sagar, Gurwinder Kaur, Anuradha Chakraborti and Rajesh Kumar
Proceedings 2025, 124(1), 9; https://doi.org/10.3390/proceedings2025124009 - 8 Aug 2025
Viewed by 353
Abstract
The significant genetic diversity among Group A Streptococcal (GAS) strains isolated from various geographical regions presents serious challenges for treatment and vaccine development strategies [...] Full article
(This article belongs to the Proceedings of The 22nd Lancefield International Symposium on Streptococci and Streptococcal Diseases (LISSSD 2025))
2 pages, 133 KB  
Abstract
Genomic Characterization and Classification of Streptococcus oralis Using Next-Generation Sequencing
by Ghiwa Chalhoub, Rayane Adam, Carmen Adam, Carni Boujanian, Rita Menhem, Peter Saba, Nancy Al Boustany, Charbel Al Khoury, Edmond Abboud, Rodrigue Saad and Sima Tokajian
Proceedings 2025, 124(1), 10; https://doi.org/10.3390/proceedings2025124010 - 8 Aug 2025
Viewed by 395
Abstract
Streptococcus oralis is an alpha-hemolytic, Gram-positive bacterium from the viridans group streptococci (VGS) [...] Full article
(This article belongs to the Proceedings of The 22nd Lancefield International Symposium on Streptococci and Streptococcal Diseases (LISSSD 2025))
2 pages, 120 KB  
Abstract
Differential Immune Response in Children to Throat Specialist Versus Generalist Group A Streptococci
by Debra E. Bessen, Jeanne M. DiChiara, Freda F. Tei, Ji Ho Lee, Ari Shechtman, Shivaleela Keerthy, Suchitra Bhattacharjee, Luiza Karrer and Sang Ho Lee
Proceedings 2025, 124(1), 11; https://doi.org/10.3390/proceedings2025124011 - 15 Aug 2025
Viewed by 352
Abstract
Background: The antigenic heterogeneity of GAS poses a challenge for vaccine design [...] Full article
(This article belongs to the Proceedings of The 22nd Lancefield International Symposium on Streptococci and Streptococcal Diseases (LISSSD 2025))
2 pages, 135 KB  
Abstract
Prevalence, Risk Factors, and Strain Distribution of Group A Streptococcus Carriage Among Indigenous Children in the Southwest United States
by Catherine G. Sutcliffe, Victoria M. Sergent, Joyselynn Pitalua, Sopio Chochua, Christopher J. Gregory, Chloe Hurley, Zhongya Li, Saundra Mathis, Lesley McGee, Jennifer Onukwube Okaro, Theresa Tran, Robert Weatherholtz and Laura L. Hammitt
Proceedings 2025, 124(1), 12; https://doi.org/10.3390/proceedings2025124012 - 13 Aug 2025
Viewed by 355
Abstract
Background [...] Full article
(This article belongs to the Proceedings of The 22nd Lancefield International Symposium on Streptococci and Streptococcal Diseases (LISSSD 2025))
2 pages, 120 KB  
Abstract
Pacific Adaptation of Tools for Implementing Rheumatic Heart Disease Control Programmes (TIPs)
by Jessica N. Daw, Rosemary Wyber and Joseph H. Kado
Proceedings 2025, 124(1), 13; https://doi.org/10.3390/proceedings2025124013 - 13 Aug 2025
Viewed by 297
Abstract
In 2013, the framework ‘Tools for Implementing Rheumatic Heart Disease (RHD) Control Programmes’ (TIPs) was published [...] Full article
(This article belongs to the Proceedings of The 22nd Lancefield International Symposium on Streptococci and Streptococcal Diseases (LISSSD 2025))
2 pages, 123 KB  
Abstract
The Veituberi Approach Transforming RHD Through Patient Leadership and Lived Experience
by Erini Kala, Marika Yalimaiwai, Maria Mow, Jimaima Kailawadoko-Matanaicake and Joseph Kado
Proceedings 2025, 124(1), 14; https://doi.org/10.3390/proceedings2025124014 - 14 Aug 2025
Viewed by 325
Abstract
Rheumatic heart disease (RHD), a complication of untreated Strep A infections, is a major global health concern [...] Full article
(This article belongs to the Proceedings of The 22nd Lancefield International Symposium on Streptococci and Streptococcal Diseases (LISSSD 2025))
2 pages, 120 KB  
Abstract
Contemporary Clinical Characteristics and Presentation of ARF Globally
by Omeir Aziz, Tehmina Kazmi, Humera Javed, Ndate Fall and Masood Sadiq
Proceedings 2025, 124(1), 15; https://doi.org/10.3390/proceedings2025124015 - 13 Aug 2025
Viewed by 251
Abstract
Background: Acute rheumatic fever (ARF) is a significant public health concern in resource-limited settings, but its clinical presentation remains inadequately described [...] Full article
(This article belongs to the Proceedings of The 22nd Lancefield International Symposium on Streptococci and Streptococcal Diseases (LISSSD 2025))
2 pages, 133 KB  
Abstract
Incidence of Invasive Group A Streptococcal Infections and Comparison of emm Types from Carriage, Pharyngitis, and Invasive Infections in Indigenous Communities in the Southwest United States
by Catherine G. Sutcliffe, Victoria M. Sergent, Joyselynn Pitalua, Sopio Chochua, Christopher J. Gregory, Chloe Hurley, Zhongya Li, Saundra Mathis, Lesley McGee, Jennifer Onukwube Okaro, Theresa Tran, Robert Weatherholtz and Laura L. Hammitt
Proceedings 2025, 124(1), 16; https://doi.org/10.3390/proceedings2025124016 - 15 Aug 2025
Viewed by 387
Abstract
Background: Indigenous communities are disproportionately affected by group A Streptococcus (GAS) infections [...] Full article
(This article belongs to the Proceedings of The 22nd Lancefield International Symposium on Streptococci and Streptococcal Diseases (LISSSD 2025))
2 pages, 120 KB  
Abstract
GAS Regulation of Zinc Homeostasis During Skin and Soft Tissue Infection
by Reid Wilkening, Lindsey Burcham, Laura Cook and Alexander Horswill
Proceedings 2025, 124(1), 17; https://doi.org/10.3390/proceedings2025124017 - 15 Aug 2025
Viewed by 357
Abstract
Streptococcus pyogenes (Group A Streptococcus, GAS) is an enigmatic human-restricted pathobiont, capable of both colonization and infection [...] Full article
(This article belongs to the Proceedings of The 22nd Lancefield International Symposium on Streptococci and Streptococcal Diseases (LISSSD 2025))
2 pages, 136 KB  
Abstract
Human Antibodies to M-Protein Epitope-Based Vaccines Demonstrate Increased Immunogenicity and Streptococcus pyogenes (StrepA) Bactericidal Activity
by Christie T. M. Short, Vanessa Meier-Stephenson, Victoria Ozberk, Ainslie Calcutt, Simone Reynolds, Ijeoma Ogbuehi, Avi Seth, Kelly Kim, Michael Hawkes, Gregory J. Tyrrell, D. Lorne Tyrrell, Michael Houghton, Manisha Pandey and Michael F. Good
Proceedings 2025, 124(1), 18; https://doi.org/10.3390/proceedings2025124018 - 18 Aug 2025
Viewed by 586
Abstract
The high antigenic diversity of Streptococcus pyogenes (StrepA) presents extensive challenges to vaccine development; however, cryptic epitopes—conserved across emm types—offer an alternative approach [...] Full article
(This article belongs to the Proceedings of The 22nd Lancefield International Symposium on Streptococci and Streptococcal Diseases (LISSSD 2025))
2 pages, 144 KB  
Abstract
Delineating Humoral and Cellular Immune Responses Induced by a Peptide-Based Vaccine for Protection Against Streptococcus pyogenes
by Despena Vedis, Ailin Lepletier, Victoria Ozberk, Simone Reynolds, Ainslie Calcutt, Darrell Bessette, Michael F. Good and Manisha Pandey
Proceedings 2025, 124(1), 19; https://doi.org/10.3390/proceedings2025124019 - 18 Aug 2025
Viewed by 429
Abstract
Despite the substantial burden of Streptococcus pyogenes infections and their associated sequalae, there is currently no Strep A vaccine [...] Full article
(This article belongs to the Proceedings of The 22nd Lancefield International Symposium on Streptococci and Streptococcal Diseases (LISSSD 2025))
2 pages, 133 KB  
Abstract
Genomic Surveillance of Streptococcus pneumoniae and Streptococcus pyogenes in the Czech Republic in the Post-COVID-19 Era
by Sandra Vohrnová, Renáta Veselá and Jana Kozáková
Proceedings 2025, 124(1), 20; https://doi.org/10.3390/proceedings2025124020 - 18 Aug 2025
Viewed by 536
Abstract
Aim: The aim of this study is to assess the impact of COVID-19 on the incidence and molecular epidemiology of invasive infections caused by Streptococcus pneumoniae (IPD) and Streptococcus pyogenes (iGAS) in the Czech Republic (CR) [...] Full article
(This article belongs to the Proceedings of The 22nd Lancefield International Symposium on Streptococci and Streptococcal Diseases (LISSSD 2025))
2 pages, 133 KB  
Abstract
Low-Dose Interleukin-2 Therapy: A Transformative Approach for the Management of Autoimmune Complications Associated with Streptococcus pyogenes Infections
by Ailin Lepletier, Rukshan Ahamed Mohamed Rafeek, Despena Vedis, Harshi Weerakoon, Natkunam Ketheesan, Michael F. Good and Manisha Pandey
Proceedings 2025, 124(1), 21; https://doi.org/10.3390/proceedings2025124021 - 22 Aug 2025
Viewed by 792
Abstract
Acute rheumatic fever is an autoimmune inflammatory reaction to Streptococcus pyogenes infections, leading to progressive heart valve damage and rheumatic heart disease (RHD) [...] Full article
(This article belongs to the Proceedings of The 22nd Lancefield International Symposium on Streptococci and Streptococcal Diseases (LISSSD 2025))
2 pages, 120 KB  
Abstract
Pericardial Effusion in Acute Rheumatic Fever and Rheumatic Heart Disease
by Tehmina Kazmi, Omeir Aziz, Humera Javed, Ansar Nawaz, Ndate Fall, Craig Sable and Masood Sadiq
Proceedings 2025, 124(1), 22; https://doi.org/10.3390/proceedings2025124022 - 15 Aug 2025
Viewed by 296
Abstract
Background: Pericardial effusion in ARF has been described in 5–10% of patients, but contemporary data is sparse [...] Full article
(This article belongs to the Proceedings of The 22nd Lancefield International Symposium on Streptococci and Streptococcal Diseases (LISSSD 2025))
2 pages, 123 KB  
Abstract
Check4Strep: A Community-Based Pilot Project to Understand and Respond to Infection with Group A Streptococcus
by Olivia Walsh, Vicki Wade, Rachel Burgess, Valerina Mungatopi, Patrick Grant, Segora Babui, Ella Meumann, Bianca Middleton, Mark Davies, Asha Bowen, Rosemary Wyber and Anna Ralph
Proceedings 2025, 124(1), 23; https://doi.org/10.3390/proceedings2025124023 - 26 Aug 2025
Viewed by 1696
Abstract
Background: ‘Check4Strep’ is a community-based, participatory action research (PAR) pilot study in a remote northern territory community [...] Full article
(This article belongs to the Proceedings of The 22nd Lancefield International Symposium on Streptococci and Streptococcal Diseases (LISSSD 2025))
2 pages, 128 KB  
Abstract
The sil System of Streptococcus anginosus: A Key Factor for Survival in Mixed Cultures
by Verena Vogel, Jana Falk, Marie Jachmann, Alina Bitzer, Lennart Herrlich and Barbara Spellerberg
Proceedings 2025, 124(1), 24; https://doi.org/10.3390/proceedings2025124024 - 28 Aug 2025
Viewed by 310
Abstract
Quorum sensing is a density-dependent form of communication in bacteria [...] Full article
(This article belongs to the Proceedings of The 22nd Lancefield International Symposium on Streptococci and Streptococcal Diseases (LISSSD 2025))
2 pages, 120 KB  
Abstract
Outcomes After Concomitant Mitral and Aortic Rheumatic Valve Surgery in Young People
by Hilary Hardefeldt, Steven Kiyokawa, Tom Gentles, Ajay Iyengar, Bryan Mitchelson, Dug Yeo Han, Kirsten Finucane and Nigel Wilson
Proceedings 2025, 124(1), 25; https://doi.org/10.3390/proceedings2025124025 - 5 Sep 2025
Viewed by 4873
Abstract
Background: Rheumatic heart disease (RHD) continues to disproportionately affect young Māori and Pacific Peoples in Aotearoa New Zealand (NZ) [...] Full article
(This article belongs to the Proceedings of The 22nd Lancefield International Symposium on Streptococci and Streptococcal Diseases (LISSSD 2025))
2 pages, 126 KB  
Abstract
Phase I Trial of a Peptide-Based Vaccine to Prevent Group A Streptococcal Infection
by Michael F. Good, Manisha Pandey, Simone Reynolds, Victoria Ozberk, Vanessa Meier-Stephenson, Michael Hawkes, Ailin Lepletier, Ainslie Calcutt, Christie Short, Ijeoma Ogbuehi, Alena Tse-Chang, Catherine Burton, Kelly Kim, Conar O’Neil, William Stokes, Maryna Yaskina, Ben Tyrrell, Scott Jamieson, Eloise Keeffe, Chris Davis, Joshua Osowicki, Andrew Steer, Greg Tyrrell, D. Lorne Tyrrell and Michael Houghtonadd Show full author list remove Hide full author list
Proceedings 2025, 124(1), 26; https://doi.org/10.3390/proceedings2025124026 - 17 Sep 2025
Viewed by 158
Abstract
We identified minimal conserved epitopes on the M-protein (J8, P*17) and the anti-neutrophil chemoattractant virulence factor, SpyCEP (K4S2), of Streptococcus pyogenes (‘Strep A’) as targets of protective antibodies [...] Full article
(This article belongs to the Proceedings of The 22nd Lancefield International Symposium on Streptococci and Streptococcal Diseases (LISSSD 2025))
2 pages, 109 KB  
Abstract
A Preliminary Study of Heart and Brain Autoreactivity After Group A Streptococcal Carbohydrate Antigen Immunization in Rabbits
by Madeleine W. Cunningham, Kathleen Alvarez, Rebecca Bentley, A. D. Sarma, C. Kamat, Marc LaForce, Francis Michon and S. S. Pisal
Proceedings 2025, 124(1), 27; https://doi.org/10.3390/proceedings2025124027 - 22 Sep 2025
Viewed by 104
Abstract
There is current interest in the group A streptococcal carbohydrate as a vaccine antigen, and previous studies have suggested that it may induce host tissue cross-reactive autoantibodies which react with heart and brain autoantigens and which are present in streptococcal sequelae, including rheumatic [...] Read more.
There is current interest in the group A streptococcal carbohydrate as a vaccine antigen, and previous studies have suggested that it may induce host tissue cross-reactive autoantibodies which react with heart and brain autoantigens and which are present in streptococcal sequelae, including rheumatic heart disease, Sydenham chorea, and pediatric autoimmune neuropsychiatric disorder associated with streptococci (PANDAS) [...] Full article
(This article belongs to the Proceedings of The 22nd Lancefield International Symposium on Streptococci and Streptococcal Diseases (LISSSD 2025))
2 pages, 113 KB  
Abstract
Development of the Rheumatic Fever Care Coordination System (RFCCS) for Aotearoa New Zealand
by Catherine Jackson, Maya Cohen-Ronen, Peter Smeaton, Denise Smith, Vladimir Obolonkin, Edward Falloon, Brad Motion, Andrew Upton and Bronwyn Petrie
Proceedings 2025, 124(1), 28; https://doi.org/10.3390/proceedings2025124028 - 22 Sep 2025
Viewed by 77
Abstract
Rates of acute rheumatic fever (ARF) and rheumatic heart disease (RHD) among New Zealand Māori and Pacific are among the highest reported in high-income countries [...] Full article
(This article belongs to the Proceedings of The 22nd Lancefield International Symposium on Streptococci and Streptococcal Diseases (LISSSD 2025))
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