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Abstract

The Emerging Role of Biomarker-Driven Diagnostics in Post-Streptococcal Glomerulonephritis †

by
Tawakaltu Abdulrasheed-Adeleke
1,2,*,
Muhammad Haruna Garba
3 and
Aliyu Evuti Haruna
2
1
Department of Biochemistry, Federal University of Technology, P.M.B. 65, Minna 920001, Niger State, Nigeria
2
Africa Centre of Excellence for Mycotoxin and Food Safety, Federal University of Technology, P.M.B. 65, Minna 920001, Niger State, Nigeria
3
Department of Biochemistry, Federal University Dutse, P.M.B. 7156, Dutse 720101, Jigawa State, Nigeria
*
Author to whom correspondence should be addressed.
Presented at the 22nd Lancefield International Symposium on Streptococci and Streptococcal Diseases, Brisbane, Australia, 1–5 June 2025.
Proceedings 2025, 124(1), 5; https://doi.org/10.3390/proceedings2025124005
Published: 6 August 2025
Post-streptococcal glomerulonephritis (PSGN) is an immune-mediated kidney disease that occurs after infection with Streptococcus pyogenes (Group A Streptococcus, GAS). Diagnosing PSGN remains challenging due to its varied clinical presentation and reliance on indirect serological markers. Identifying specific biomarkers is crucial for early detection and improved patient outcomes. Recent studies have identified key biomarkers such as Nephritis-Associated Plasmin Receptor (NAPlr) and Streptococcal Pyrogenic Exotoxin B (SpeB), both of which contribute to immune complex formation and glomerular inflammation. Additionally, elevated levels of C3 breakdown products, the soluble urokinase plasminogen activator receptor (suPAR), and urinary exosomal proteins have shown strong correlations with disease severity and kidney dysfunction. Advancements in OMICS technologies have revolutionized PSGN diagnostics. Proteomics has uncovered unique urinary protein signatures, while metabolomics has identified metabolic shifts linked to kidney injury. Transcriptomic analysis has further enhanced our understanding of gene expression changes in PSGN, thus paving the way for precision diagnostics. Innovative point-of-care (POC) diagnostic tools, integrating biosensors and microfluidic assays, allow the real-time detection of PSGN-specific biomarkers, enabling early intervention and personalized treatment strategies. These developments are promising for improving disease monitoring and reducing the risk of long-term renal complications. This review highlights the emerging role of biomarker-driven diagnostics in PSGN, emphasizing the potential of OMICS-based approaches to refine detection methods, enhance clinical decision-making, and ultimately improve patient prognosis.

Author Contributions

Writing—original draft preparation, T.A.-A.; Writing—review and editing, T.A.-A., M.H.G. and A.E.H.; proofread the manuscript for technical compliance before submission of original manuscript, T.A.-A., M.H.G. and A.E.H. All authors have read and agreed to the published version of the manuscript.

Funding

This review received no external funding.

Institutional Review Board Statement

Not applicable.

Informed Consent Statement

Not applicable.

Data Availability Statement

Not applicable.

Acknowledgments

The corresponding author, T. Abdulrasheed-Adeleke, hereby acknowledges the Lancefield International Symposium Travel Grant received from the Lancefield Society to attend and present a poster at the 22nd Lancefield International Symposium on Streptococci and Streptococcal Diseases (LISSSD) 2025 Conference at Brisbane Convention and Exhibition Center Brisbane, Queensland, Australia from 1–5 June 2025.

Conflicts of Interest

The authors declare no conflict of interest.
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Share and Cite

MDPI and ACS Style

Abdulrasheed-Adeleke, T.; Garba, M.H.; Haruna, A.E. The Emerging Role of Biomarker-Driven Diagnostics in Post-Streptococcal Glomerulonephritis. Proceedings 2025, 124, 5. https://doi.org/10.3390/proceedings2025124005

AMA Style

Abdulrasheed-Adeleke T, Garba MH, Haruna AE. The Emerging Role of Biomarker-Driven Diagnostics in Post-Streptococcal Glomerulonephritis. Proceedings. 2025; 124(1):5. https://doi.org/10.3390/proceedings2025124005

Chicago/Turabian Style

Abdulrasheed-Adeleke, Tawakaltu, Muhammad Haruna Garba, and Aliyu Evuti Haruna. 2025. "The Emerging Role of Biomarker-Driven Diagnostics in Post-Streptococcal Glomerulonephritis" Proceedings 124, no. 1: 5. https://doi.org/10.3390/proceedings2025124005

APA Style

Abdulrasheed-Adeleke, T., Garba, M. H., & Haruna, A. E. (2025). The Emerging Role of Biomarker-Driven Diagnostics in Post-Streptococcal Glomerulonephritis. Proceedings, 124(1), 5. https://doi.org/10.3390/proceedings2025124005

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