You are currently viewing a new version of our website. To view the old version click .

Tropical Medicine and Infectious Disease, Volume 8, Issue 12

December 2023 - 18 articles

Cover Story: Metacestodes of the fox tapeworm Echinococcus multilocularis cause the severe disease alveolar echinococcosis in humans and animals. Current drug treatment options are not curative and there is a strong need for the development of novel therapeutic agents against this parasite. In the search for compounds, we apply an established in vitro drug screening cascade against E. multilocularis metacestode vesicles and isolated primary cells of this parasite. In this manuscript, we tested disulfiram and 51 dithiocarbamate derivatives in this screening cascade, because these compounds have been shown to have promising activity against the trematode Schistosoma mansoni. Our studies revealed that the structure class of dithiocarbamate derivatives can provide new potential anti-echinococcal drugs. View this paper
  • Issues are regarded as officially published after their release is announced to the table of contents alert mailing list .
  • You may sign up for email alerts to receive table of contents of newly released issues.
  • PDF is the official format for papers published in both, html and pdf forms. To view the papers in pdf format, click on the "PDF Full-text" link, and use the free Adobe Reader to open them.

Articles (18)

  • Article
  • Open Access
1 Citations
2,633 Views
12 Pages

Inter-observer Variability in the Analysis of CO-RADS Classification for COVID-19 Patients

  • Yassir Edrees Almalki,
  • Mohammad Abd Alkhalik Basha,
  • Maha Ibrahim Metwally,
  • Ahmed Mohamed Housseini,
  • Sharifa Khalid Alduraibi,
  • Ziyad A. Almushayti,
  • Asim S. Aldhilan,
  • Mahmoud Mohamed Elzoghbi,
  • Esraa Attia Gabr and
  • Esaraa Manajrah
  • + 5 authors

During the early stages of the pandemic, computed tomography (CT) of the chest, along with serological and clinical data, was frequently utilized in diagnosing COVID-19, particularly in regions facing challenges such as shortages of PCR kits. In thes...

  • Brief Report
  • Open Access
4 Citations
4,281 Views
9 Pages

This study aimed to assess the prevalence and identify risk factors of schistosomiasis among school-aged children in low- and middle-income communities. A retrospective cross-sectional study was conducted to review patient records of school-age child...

  • Article
  • Open Access
2 Citations
2,829 Views
11 Pages

Background: Infections are a major cause of morbidity and mortality in patients with pemphigus vulgaris (PV). One of the most common infections in these patients is candidiasis. This is probably due to the use of systemic immunosuppressants, includin...

  • Article
  • Open Access
4 Citations
4,849 Views
10 Pages

High Tuberculosis Preventive Treatment Uptake and Completion Rates Using a Person-Centered Approach among Tuberculosis Household Contact in Yogyakarta

  • Felisia Felisia,
  • Rina Triasih,
  • Betty Weri Yolanda Nababan,
  • Guardian Yoki Sanjaya,
  • Setyogati Candra Dewi,
  • Endang Sri Rahayu,
  • Lana Unwanah,
  • Philipp du Cros and
  • Geoffrey Chan

Coverage of tuberculosis preventive treatment (TPT) in Indonesia is inadequate, and persons who start TPT often do not complete treatment. In 2020, Zero TB Yogyakarta implemented person-centered contact investigation and shorter TPT regimen provision...

  • Article
  • Open Access
6 Citations
2,964 Views
13 Pages

Record Linkage for Malaria Deaths Data Recovery and Surveillance in Brazil

  • Klauss Kleydmann Sabino Garcia,
  • Danielly Batista Xavier,
  • Seyi Soremekun,
  • Amanda Amaral Abrahão,
  • Chris Drakeley,
  • Walter Massa Ramalho and
  • André M. Siqueira

Objective: The objective is to describe the results and the methodological processes of record linkage for matching deaths and malaria cases. Methods: A descriptive cross-sectional study was conducted with probabilistic record linkage of death and ma...

  • Article
  • Open Access
5 Citations
3,620 Views
12 Pages

Evaluation of Loop-Mediated Isothermal Amplification (LAMP) in Urine Samples for the Diagnosis of Imported Schistosomiasis

  • Joaquín Salas-Coronas,
  • María Pilar Luzón-García,
  • Beatriz Crego-Vicente,
  • Manuel Jesús Soriano-Pérez,
  • Begoña Febrer-Sendra,
  • José Vázquez-Villegas,
  • Juan García-Bernalt Diego,
  • Isabel María Cabeza-Barrera,
  • Nerea Castillo-Fernández and
  • Antonio Muro
  • + 2 authors

Migratory flows and international travel are triggering an increase in imported cases of schistosomiasis in non-endemic countries. The present study aims to evaluate the effectiveness of the LAMP technique on patients’ urine samples for the dia...

  • Article
  • Open Access
2 Citations
2,964 Views
13 Pages

In Vitro Activities of Dithiocarbamate Derivatives against Echinococcus multilocularis Metacestode Vesicles

  • Marc Kaethner,
  • Georg Rennar,
  • Tom Gallinger,
  • Tobias Kämpfer,
  • Andrew Hemphill,
  • Patrick Mäder,
  • Ana Luque-Gómez,
  • Martin Schlitzer and
  • Britta Lundström-Stadelmann

The metacestode stage of the fox tapeworm Echinococcus multilocularis causes the severe zoonotic disease alveolar echinococcosis. New treatment options are urgently needed. Disulfiram and dithiocarbamates were previously shown to exhibit activity aga...

  • Article
  • Open Access
1 Citations
2,521 Views
11 Pages

Trends of Infective Endocarditis at Two Teaching Hospitals: A 12-Year Retrospective Cohort Study in Rio de Janeiro, Brazil

  • Paulo Vieira Damasco,
  • Victor Edgar Fiestas Solórzano,
  • Natália Rodrigues Querido Fortes,
  • Daniel Xavier de Brito Setta,
  • Aloysio Guimaraes da Fonseca,
  • Mario Castro Alvarez Perez,
  • João Carlos Jazbick,
  • Jonathan Gonçalves-Oliveira,
  • Marco Aurélio Pereira Horta and
  • Elba Regina Sampaio de Lemos
  • + 1 author

Background: Despite advances in diagnosis and treatment, the incidence and mortality of infective endocarditis (IE) have increased in recent decades. Studies on the risk factors for mortality in endocarditis in Latin America are scarce. Methods: This...

  • Article
  • Open Access
2 Citations
3,027 Views
10 Pages

Assessment of Community Awareness and Screening of Chagas Disease in the Latin American Community of Greater New Orleans

  • Claudia Herrera,
  • Kerlly J. Bernabé,
  • Eric Dumonteil,
  • James DeCuir,
  • Julie M. Thompson,
  • Mariana Avendano,
  • Weihong Tu,
  • Maxwell M. Leonhardt,
  • Bianka A. Northland and
  • Jynx Frederick
  • + 6 authors

Chagas disease is a public health problem in the Americas, from the southern United States (USA) to Argentina. In the USA, less than 1% of domestic cases have been identified and less than 0.3% of total cases have received treatment. Little is known...

  • Review
  • Open Access
2 Citations
2,783 Views
20 Pages

To determine the performance and reliability of diagnostic tests for the identification of SARS-CoV-2 infection in South Africa, we conducted a scoping review to identify published studies undertaken in the English language from March 2020 to August...

of 2

Get Alerted

Add your email address to receive forthcoming issues of this journal.

XFacebookLinkedIn
Trop. Med. Infect. Dis. - ISSN 2414-6366