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Tropical Medicine and Infectious Disease, Volume 8, Issue 12

2023 December - 18 articles

Cover Story: Metacestodes of the fox tapeworm Echinococcus multilocularis cause the severe disease alveolar echinococcosis in humans and animals. Current drug treatment options are not curative and there is a strong need for the development of novel therapeutic agents against this parasite. In the search for compounds, we apply an established in vitro drug screening cascade against E. multilocularis metacestode vesicles and isolated primary cells of this parasite. In this manuscript, we tested disulfiram and 51 dithiocarbamate derivatives in this screening cascade, because these compounds have been shown to have promising activity against the trematode Schistosoma mansoni. Our studies revealed that the structure class of dithiocarbamate derivatives can provide new potential anti-echinococcal drugs. View this paper
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Articles (18)

  • Article
  • Open Access
1 Citations
2,823 Views
12 Pages

Inter-observer Variability in the Analysis of CO-RADS Classification for COVID-19 Patients

  • Yassir Edrees Almalki,
  • Mohammad Abd Alkhalik Basha,
  • Maha Ibrahim Metwally,
  • Ahmed Mohamed Housseini,
  • Sharifa Khalid Alduraibi,
  • Ziyad A. Almushayti,
  • Asim S. Aldhilan,
  • Mahmoud Mohamed Elzoghbi,
  • Esraa Attia Gabr and
  • Walid Mosallam
  • + 5 authors

During the early stages of the pandemic, computed tomography (CT) of the chest, along with serological and clinical data, was frequently utilized in diagnosing COVID-19, particularly in regions facing challenges such as shortages of PCR kits. In thes...

  • Brief Report
  • Open Access
4 Citations
4,472 Views
9 Pages

This study aimed to assess the prevalence and identify risk factors of schistosomiasis among school-aged children in low- and middle-income communities. A retrospective cross-sectional study was conducted to review patient records of school-age child...

  • Article
  • Open Access
3 Citations
3,004 Views
11 Pages

Background: Infections are a major cause of morbidity and mortality in patients with pemphigus vulgaris (PV). One of the most common infections in these patients is candidiasis. This is probably due to the use of systemic immunosuppressants, includin...

  • Article
  • Open Access
6 Citations
5,325 Views
10 Pages

High Tuberculosis Preventive Treatment Uptake and Completion Rates Using a Person-Centered Approach among Tuberculosis Household Contact in Yogyakarta

  • Felisia Felisia,
  • Rina Triasih,
  • Betty Weri Yolanda Nababan,
  • Guardian Yoki Sanjaya,
  • Setyogati Candra Dewi,
  • Endang Sri Rahayu,
  • Lana Unwanah,
  • Philipp du Cros and
  • Geoffrey Chan

Coverage of tuberculosis preventive treatment (TPT) in Indonesia is inadequate, and persons who start TPT often do not complete treatment. In 2020, Zero TB Yogyakarta implemented person-centered contact investigation and shorter TPT regimen provision...

  • Article
  • Open Access
6 Citations
3,115 Views
13 Pages

Record Linkage for Malaria Deaths Data Recovery and Surveillance in Brazil

  • Klauss Kleydmann Sabino Garcia,
  • Danielly Batista Xavier,
  • Seyi Soremekun,
  • Amanda Amaral Abrahão,
  • Chris Drakeley,
  • Walter Massa Ramalho and
  • André M. Siqueira

Objective: The objective is to describe the results and the methodological processes of record linkage for matching deaths and malaria cases. Methods: A descriptive cross-sectional study was conducted with probabilistic record linkage of death and ma...

  • Article
  • Open Access
5 Citations
3,800 Views
12 Pages

Evaluation of Loop-Mediated Isothermal Amplification (LAMP) in Urine Samples for the Diagnosis of Imported Schistosomiasis

  • Joaquín Salas-Coronas,
  • María Pilar Luzón-García,
  • Beatriz Crego-Vicente,
  • Manuel Jesús Soriano-Pérez,
  • Begoña Febrer-Sendra,
  • José Vázquez-Villegas,
  • Juan García-Bernalt Diego,
  • Isabel María Cabeza-Barrera,
  • Nerea Castillo-Fernández and
  • Pedro Fernández-Soto
  • + 2 authors

Migratory flows and international travel are triggering an increase in imported cases of schistosomiasis in non-endemic countries. The present study aims to evaluate the effectiveness of the LAMP technique on patients’ urine samples for the dia...

  • Article
  • Open Access
2 Citations
3,107 Views
13 Pages

In Vitro Activities of Dithiocarbamate Derivatives against Echinococcus multilocularis Metacestode Vesicles

  • Marc Kaethner,
  • Georg Rennar,
  • Tom Gallinger,
  • Tobias Kämpfer,
  • Andrew Hemphill,
  • Patrick Mäder,
  • Ana Luque-Gómez,
  • Martin Schlitzer and
  • Britta Lundström-Stadelmann

The metacestode stage of the fox tapeworm Echinococcus multilocularis causes the severe zoonotic disease alveolar echinococcosis. New treatment options are urgently needed. Disulfiram and dithiocarbamates were previously shown to exhibit activity aga...

  • Article
  • Open Access
1 Citations
2,660 Views
11 Pages

Trends of Infective Endocarditis at Two Teaching Hospitals: A 12-Year Retrospective Cohort Study in Rio de Janeiro, Brazil

  • Paulo Vieira Damasco,
  • Victor Edgar Fiestas Solórzano,
  • Natália Rodrigues Querido Fortes,
  • Daniel Xavier de Brito Setta,
  • Aloysio Guimaraes da Fonseca,
  • Mario Castro Alvarez Perez,
  • João Carlos Jazbick,
  • Jonathan Gonçalves-Oliveira,
  • Marco Aurélio Pereira Horta and
  • Claudio Querido Fortes
  • + 1 author

Background: Despite advances in diagnosis and treatment, the incidence and mortality of infective endocarditis (IE) have increased in recent decades. Studies on the risk factors for mortality in endocarditis in Latin America are scarce. Methods: This...

  • Article
  • Open Access
2 Citations
3,281 Views
10 Pages

Assessment of Community Awareness and Screening of Chagas Disease in the Latin American Community of Greater New Orleans

  • Claudia Herrera,
  • Kerlly J. Bernabé,
  • Eric Dumonteil,
  • James DeCuir,
  • Julie M. Thompson,
  • Mariana Avendano,
  • Weihong Tu,
  • Maxwell M. Leonhardt,
  • Bianka A. Northland and
  • Margarita Echeverri
  • + 6 authors

Chagas disease is a public health problem in the Americas, from the southern United States (USA) to Argentina. In the USA, less than 1% of domestic cases have been identified and less than 0.3% of total cases have received treatment. Little is known...

  • Review
  • Open Access
2 Citations
2,873 Views
20 Pages

To determine the performance and reliability of diagnostic tests for the identification of SARS-CoV-2 infection in South Africa, we conducted a scoping review to identify published studies undertaken in the English language from March 2020 to August...

  • Review
  • Open Access
33 Citations
6,520 Views
14 Pages

Chagas Disease in Europe

  • Marta Gonzalez-Sanz,
  • Clara Crespillo-Andújar,
  • Sandra Chamorro-Tojeiro,
  • Begoña Monge-Maillo,
  • Jose A. Perez-Molina and
  • Francesca F. Norman

Chagas disease is currently present in many non-endemic countries and remains a neglected tropical disease globally. A review of the literature identified significant gaps and scarcity of updated information from European countries, with most studies...

  • Article
  • Open Access
15 Citations
5,862 Views
21 Pages

Outcomes and Challenges in the Programmatic Implementation of Tuberculosis Preventive Therapy among Household Contacts of Pulmonary TB Patients: A Mixed-Methods Study from a Rural District of Karnataka, India

  • U. C. Samudyatha,
  • Kathirvel Soundappan,
  • Gomathi Ramaswamy,
  • Kedar Mehta,
  • Chandan Kumar,
  • M. Jagadeesh,
  • B. T. Prasanna Kamath,
  • Neeta Singla and
  • Pruthu Thekkur

The National TB Elimination Programme (NTEP) of India is implementing tuberculosis preventive treatment (TPT) for all household contacts (HHCs) of pulmonary tuberculosis patients (index patients) aged <5 years and those HHCs aged >5 years with...

  • Article
  • Open Access
13 Citations
5,740 Views
11 Pages

Prevalence of Human Papillomavirus Infection and Cervical Abnormalities among Women Attending a Tertiary Care Center in Saudi Arabia over 2 Years

  • Layla Faqih,
  • Lama Alzamil,
  • Esraa Aldawood,
  • Sarah Alharbi,
  • Moammer Muzzaffar,
  • Amani Moqnas,
  • Heba Almajed,
  • Ahmed Alghamdi,
  • Mohammed Alotaibi and
  • Yazeed Alwelaie
  • + 1 author

Human papillomavirus (HPV) genotype distribution varies according to the assessment method and the population targeted. This study aimed to assess HPV infection prevalence in women aged 23 to 82 with abnormal cytology attending King Fahad Medical Cit...

  • Article
  • Open Access
6 Citations
3,381 Views
16 Pages

Medicines for Malaria Venture Pandemic Box In Vitro Screening Identifies Compounds Highly Active against the Tachyzoite Stage of Toxoplasma gondii

  • Mike dos Santos,
  • Andréia Luiza Oliveira Costa,
  • Guilherme Henrique de Souza Vaz,
  • Gabriela Carolina Alves de Souza,
  • Ricardo Wagner de Almeida Vitor and
  • Érica S. Martins-Duarte

Toxoplasmosis is a disease that causes high mortality in immunocompromised individuals, such as AIDS patients, and sequelae in congenitally infected newborns. Despite its great medical importance, there are few treatments available and these are asso...

  • Article
  • Open Access
6 Citations
3,120 Views
10 Pages

A 7-Year Survey (2015–2021) in One Pediatric Hospital (Brasov, Romania) on Rotavirus Gastroenteritis Specified as Community- or Hospital-Acquired Infection in Young Children

  • Ioana Arbanas,
  • Vlad Monescu,
  • Niculina Dragomir,
  • Larisa Diana Sauciuc,
  • Emanuela Cojocaru,
  • Katalin Csutak,
  • Bianca Elena Popovici,
  • Pandaru Andreea,
  • Spirea Elena-Daniela and
  • Oana Falup-Pecurariu
  • + 2 authors

This project is an observational, descriptive study evaluating frequencies of rotavirus disease in hospitalized children aged less than 5 years old between 2015 and 2021 in the Pediatric Hospital of Brasov, Central Romania. The study compares socio-d...

  • Systematic Review
  • Open Access
14 Citations
6,196 Views
22 Pages

Powassan Virus Infections: A Systematic Review of Published Cases

  • Loukas Kakoullis,
  • Victor Renault Vaz,
  • Divmehar Kaur,
  • Sonia Kakoulli,
  • George Panos,
  • Lin H. Chen and
  • Irmgard Behlau

Background: Powassan virus is an emerging neurotropic arbovirus transmitted by the tick Ixodes scapularis. This systematic review was conducted to aggregate data on its clinical manifestations, diagnostic findings, and complications. Methods: PubMed...

  • Article
  • Open Access
10 Citations
5,351 Views
10 Pages

Cutaneous Leishmaniasis Prevalence and Clinical Overview: A Single Center Study from Saudi Arabia, Eastern Region, Al-Ahsa

  • Mahdi Al-Dhafiri,
  • Abdulmohsen Alhajri,
  • Zahraa Ali Alwayel,
  • Jasmine Ahmed Alturaiki,
  • Shaima Ali Bu Izran,
  • Fatimah Ahmed Alhammad and
  • Ryhana Mohammed Aljumaiah

Cutaneous leishmaniasis (CL) is a vector-borne parasitic disease that is transmitted via the bites of infected female sandflies. CL has been endemic in several countries worldwide for many decades, and numerous cases have been reported in Saudi Arabi...

  • Review
  • Open Access
8 Citations
4,769 Views
16 Pages

Clostridioides difficile infection (CDI) is a leading nosocomial infection, posing a substantial public health challenge within the United States and globally. CDI typically occurs in hospitalized elderly patients who have been administered antibioti...

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Trop. Med. Infect. Dis. - ISSN 2414-6366