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Commentary
Peer-Review Record

Advancing Therapies for Cancer—From Mustard Gas to CAR T

Reviewer 1: Helmout Modjtahedi
Reviewer 2: Radosław Zagożdżon
Received: 27 May 2020 / Accepted: 5 June 2020 / Published: 7 December 2020
Version 1
DOI: 10.3390/sci2020042

Version 2
DOI: 10.3390/sci2030070

Round 1

Reviewer 1 Report

This is a very well written commentary highlighting "Key Advances in Cancer Therapeutics".

Perhaps, this commentary will be strengthened if the authors could also mention targeted therapy using the checkpoint inhibitors and by including a recent review article as a supporting reference for this approach.

Author Response

This is a very well written commentary highlighting "Key Advances in Cancer Therapeutics". Perhaps, this commentary will be strengthened if the authors could also mention targeted therapy using the checkpoint inhibitors and by including a recent review article as a supporting reference for this approach. Thank you for your comments. We have indeed mentioned checkpoint inhibition and included a reference.

Reviewer 2 Report

In their manuscript, the Authors summarize in brief the most pronounced advances in the systemic therapies for cancer. The manuscript is well-written and provides significant information in this area.

Minor comments:

  1. It would be worth mentioning that targeting the cancer-associated immune checkpoints by monoclonal antibodies has been one of the most important advances in strategies for re-shaping the specific immune response against cancer.
  2. Perhaps the Authors could also mention, as future perspectives, the potential change in targeted therapies against cancer that might occur if gene editing strategies enter clinical oncology with a considerable success.

Author Response

In their manuscript, the Authors summarize in brief the most pronounced advances in the systemic therapies for cancer. The manuscript is well-written and provides significant information in this area. Minor comments: 1. It would be worth mentioning that targeting the cancer-associated immune checkpoints by monoclonal antibodies has been one of the most important advances in strategies for re-shaping the specific immune response against cancer. 2. Perhaps the Authors could also mention, as future perspectives, the potential change in targeted therapies against cancer that might occur if gene editing strategies enter clinical oncology with a considerable success. Thank you for your comments. We have indeed mentioned gene therapy and antibody-immune checkpoint therapies as two important developments/future directions in the field.
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