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Commentary

Advancing Therapies for Cancer—From Mustard Gas to CAR T

1
Department of Bioengineering, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA
2
Cell and Molecular Biology Program, Colorado State University, Fort Collins, CO 80523, USA
3
Department of Clinical Sciences, Colorado State University, Fort Collins, CO 80523, USA
4
Epidemiology Section, Colorado School of Public Health, Colorado State University, Fort Collins, CO 80523, USA
*
Author to whom correspondence should be addressed.
Received: 27 May 2020 / Accepted: 5 June 2020 / Published: 7 December 2020
The development of targeted therapeutics for cancer continues to receive intense research attention as laboratories and pharmaceutical companies seek to develop drugs and technologies that improve treatment efficacy and mitigate harmful side effects. In the aftermath of World War I, it was discovered that mustard gas destroys rapidly dividing cells and could be used to treat cancer. Since then, chemotherapy has remained a predominant treatment for cancer; however, the destruction of dividing cells throughout the body yields devastating side effects including off-target damage of the digestive tract, bone marrow, skin, and reproductive tract. Furthermore, the high mutation rate of cancerous cells often renders chemotherapy ineffective long-term. Therapies with improved specificity, localization, and efficacy are redefining cancer treatment. Herein, we define and summarize the principal advancements in targeted cancer treatment and briefly comment on the march towards personalized medicine in the treatment of human cancer. View Full-Text
Keywords: small molecule inhibitor; personalized medicine; precision medicine; oncology; targeted therapy; drug delivery; drug screening; chemotherapy small molecule inhibitor; personalized medicine; precision medicine; oncology; targeted therapy; drug delivery; drug screening; chemotherapy
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MDPI and ACS Style

Jarrell, D.K.; Drake, S.; Brown, M.A. Advancing Therapies for Cancer—From Mustard Gas to CAR T. Sci 2020, 2, 90. https://doi.org/10.3390/sci2040090

AMA Style

Jarrell DK, Drake S, Brown MA. Advancing Therapies for Cancer—From Mustard Gas to CAR T. Sci. 2020; 2(4):90. https://doi.org/10.3390/sci2040090

Chicago/Turabian Style

Jarrell, Dillon K., Seth Drake, and Mark A. Brown. 2020. "Advancing Therapies for Cancer—From Mustard Gas to CAR T" Sci 2, no. 4: 90. https://doi.org/10.3390/sci2040090

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