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Instruments 2018, 2(4), 25; https://doi.org/10.3390/instruments2040025

Correction of Geometrical Effects of a Knife-Edge Slit Camera for Prompt Gamma-Based Range Verification in Proton Therapy

1
Ion Beam Applications SA, 1348 Louvain-la-Neuve, Belgium
2
OncoRay—National Center for Radiation Research in Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Helmholtz-Zentrum Dresden—Rossendorf, 01328 Dresden, Germany
3
Helmholtz-Zentrum Dresden—Rossendorf, Institute of Radiooncology—OncoRay, 01309 Dresden, Germany
4
Department of Radiotherapy and Radiation Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, 01309 Dresden, Germany
5
German Cancer Consortium (DKTK), Partner Site Dresden, and German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany
Current address: Paul Scherrer Institut (PSI), 5232 Villigen, Switzerland
*
Author to whom correspondence should be addressed.
Received: 26 September 2018 / Revised: 2 November 2018 / Accepted: 6 November 2018 / Published: 10 November 2018
(This article belongs to the Special Issue Diagnostics for Beam and Patient Monitoring)
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Abstract

Prompt gamma (PG) based range verification can potentially reduce the safety margins in proton therapy. A knife-edge slit camera has been developed in this context using analytical PG simulations as reference for absolute range verification during patient treatment. Geometrical deviations between measurement and simulation could be observed and have to be corrected for in order to improve the range retrieval of the system. A geometrical correction model is derived from Monte Carlo simulations in water. The influence of different parameters is tested and the model is validated in a dedicated benchmark experiment. We found that the geometrical correction improves the agreement between measured and simulated PG profiles resulting in an improved range retrieval and higher accuracy for absolute range verification. An intrinsic offset of 1.4 mm between measurement and simulation is observed in the experimental data and corrected in the PG simulation. In summary, the absolute range verification capabilities of a PG camera have been improved by applying a geometrical correction model. View Full-Text
Keywords: prompt gamma; proton therapy; range verification; Monte Carlo simulation prompt gamma; proton therapy; range verification; Monte Carlo simulation
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Petzoldt, J.; Janssens, G.; Nenoff, L.; Richter, C.; Smeets, J. Correction of Geometrical Effects of a Knife-Edge Slit Camera for Prompt Gamma-Based Range Verification in Proton Therapy. Instruments 2018, 2, 25.

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