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Article

Implications of the Harmonization of [18F]FDG-PET/CT Imaging for Response Assessment of Treatment in Radiotherapy Planning

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Departamento de Fisiología Médica y Biofísica, Universidad de Sevilla, 41009 Seville, Spain
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Instituto de Biomedicina de Sevilla, IBiS, 41013 Seville, Spain
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Medical Radiation Physics, Department of Physics, Stockholm University, 114 21 Stockholm, Sweden
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Centro Nacional de Aceleradores (CNA), Universidad de Sevilla, Junta de Andalucía, Consejo Superior de Investigaciones Científicas (CSIC), 41092 Seville, Spain
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Hospital Universitario Virgen Macarena, Servicio de Radioterapia, 41009 Seville, Spain
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Hospital Universitario Virgen Macarena, Servicio de Medicina Nuclear, 41009 Seville, Spain
*
Author to whom correspondence should be addressed.
Academic Editor: Francis Man
Tomography 2022, 8(2), 1097-1112; https://doi.org/10.3390/tomography8020090
Received: 3 February 2022 / Revised: 6 April 2022 / Accepted: 7 April 2022 / Published: 12 April 2022
(This article belongs to the Special Issue Therapy Monitoring Based on PET Imaging)
The purpose of this work is to present useful recommendations for the use of [18F]FDG-PET/CT imaging in radiotherapy planning and monitoring under different versions of EARL accreditation for harmonization of PET devices. A proof-of-concept experiment designed on an anthropomorphic phantom was carried out to establish the most suitable interpolation methods of the PET images in the different steps of the planning procedure. Based on PET/CT images obtained by using these optimal interpolations for the old EARL accreditation (EARL1) and for the new one (EARL2), the treatment plannings of representative actual clinical cases were calculated, and the clinical implications of the resulting differences were analyzed. As expected, EARL2 provided smaller volumes with higher resolution than EARL1. The increase in the size of the reconstructed volumes with EARL1 accreditation caused high doses in the organs at risk and in the regions adjacent to the target volumes. EARL2 accreditation allowed an improvement in the accuracy of the PET imaging precision, allowing more personalized radiotherapy. This work provides recommendations for those centers that intend to benefit from the new accreditation, EARL2, and can help build confidence of those that must continue working under the EARL1 accreditation. View Full-Text
Keywords: EANM guidelines; EARL accreditation; harmonization; FDG-PET; reconstruction protocol; radiotherapy planning; dose painting; FDG monitoring EANM guidelines; EARL accreditation; harmonization; FDG-PET; reconstruction protocol; radiotherapy planning; dose painting; FDG monitoring
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MDPI and ACS Style

Jiménez-Ortega, E.; Agüera, R.; Ureba, A.; Balcerzyk, M.; Wals-Zurita, A.; García-Gómez, F.J.; Leal, A. Implications of the Harmonization of [18F]FDG-PET/CT Imaging for Response Assessment of Treatment in Radiotherapy Planning. Tomography 2022, 8, 1097-1112. https://doi.org/10.3390/tomography8020090

AMA Style

Jiménez-Ortega E, Agüera R, Ureba A, Balcerzyk M, Wals-Zurita A, García-Gómez FJ, Leal A. Implications of the Harmonization of [18F]FDG-PET/CT Imaging for Response Assessment of Treatment in Radiotherapy Planning. Tomography. 2022; 8(2):1097-1112. https://doi.org/10.3390/tomography8020090

Chicago/Turabian Style

Jiménez-Ortega, Elisa, Raquel Agüera, Ana Ureba, Marcin Balcerzyk, Amadeo Wals-Zurita, Francisco J. García-Gómez, and Antonio Leal. 2022. "Implications of the Harmonization of [18F]FDG-PET/CT Imaging for Response Assessment of Treatment in Radiotherapy Planning" Tomography 8, no. 2: 1097-1112. https://doi.org/10.3390/tomography8020090

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