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Diagnostic Performance of Preoperative Choline-PET/CT in Patients Undergoing Salvage Lymph Node Dissection for Recurrent Prostate Cancer: A Multicenter Experience

1
Second Department of Urology, Centre of Postgraduate Medical Education, 01-809 Warsaw, Poland
2
Department of Minimally Invasive and Robotic Urology, University Center of Excellence in Urology, Wrocław Medical University, 50-556 Wrocław, Poland
3
Department of Urology and Urological Oncology, Pomeranian Medical University, 70-111 Szczecin, Poland
*
Author to whom correspondence should be addressed.
Academic Editor: Tore Bach-Gansmo
Tomography 2022, 8(2), 1090-1096; https://doi.org/10.3390/tomography8020089
Received: 25 February 2022 / Revised: 31 March 2022 / Accepted: 7 April 2022 / Published: 11 April 2022
(This article belongs to the Special Issue Advances in the Radiography of Prostate Cancer)
We aimed to retrospectively analyze consecutive prostate cancer patients diagnosed with biochemical or clinical recurrence after local treatment with curative intent, with no evidence of distant metastases, who underwent positron emission tomography/computed tomography (PET/CT) with choline followed by salvage lymph node dissection (SLND) in three academic centers between 2013 and 2020. A total of 27 men were included in the analyses. Sensitivity, specificity, positive and negative predictive values, and accuracy of choline-PET/CT in predicting pathology-proven lymph node involvement were 75%, 43%, 79%, 38% and 67% on per-patient and 70%, 86%, 80%, 78%, and 79% on per-site analyses, respectively, with the differences in specificity and NPV between per-patient and per-site analyses being statistically significant (p = 0.03 and 0.04, respectively). The study provides further insight into the role of preoperative choline-PET/CT in patients undergoing SLND for recurrent PC. View Full-Text
Keywords: positron emission tomography computed tomography; prostatic neoplasms; salvage therapy; predictive value of tests; sensitivity and specificity positron emission tomography computed tomography; prostatic neoplasms; salvage therapy; predictive value of tests; sensitivity and specificity
MDPI and ACS Style

Nyk, Ł.; Kamecki, H.; Krajewski, W.; Małkiewicz, B.; Szydełko, T.; Kubis, M.; Słojewski, M.; Kryst, P.; Poletajew, S.; Malewski, W. Diagnostic Performance of Preoperative Choline-PET/CT in Patients Undergoing Salvage Lymph Node Dissection for Recurrent Prostate Cancer: A Multicenter Experience. Tomography 2022, 8, 1090-1096. https://doi.org/10.3390/tomography8020089

AMA Style

Nyk Ł, Kamecki H, Krajewski W, Małkiewicz B, Szydełko T, Kubis M, Słojewski M, Kryst P, Poletajew S, Malewski W. Diagnostic Performance of Preoperative Choline-PET/CT in Patients Undergoing Salvage Lymph Node Dissection for Recurrent Prostate Cancer: A Multicenter Experience. Tomography. 2022; 8(2):1090-1096. https://doi.org/10.3390/tomography8020089

Chicago/Turabian Style

Nyk, Łukasz, Hubert Kamecki, Wojciech Krajewski, Bartosz Małkiewicz, Tomasz Szydełko, Markiian Kubis, Marcin Słojewski, Piotr Kryst, Sławomir Poletajew, and Wojciech Malewski. 2022. "Diagnostic Performance of Preoperative Choline-PET/CT in Patients Undergoing Salvage Lymph Node Dissection for Recurrent Prostate Cancer: A Multicenter Experience" Tomography 8, no. 2: 1090-1096. https://doi.org/10.3390/tomography8020089

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