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Tomography
Volume 5
Issue 1
10.18383/j.tom.2018.00029
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Article

Real-Time Quantitative Assessment of Accuracy and Precision of Blood Volume Derived from DCE-MRI in Individual Patients during a Clinical Trial

by
Madhava P. Aryal
1,*,
Choonik Lee
1,
Peter G. Hawkins
1,
Christina Chapman
1,
Avraham Eisbruch
1,
Michelle Mierzwa
1 and
Yue Cao
1,2,3
1
Departments of Radiation Oncology, University of Michigan, Ann Arbor, MI 48103, USA
2
Departments of Radiology, University of Michigan, Ann Arbor, MI 48103, USA
3
Departments of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48103, USA
*
Author to whom correspondence should be addressed.
Tomography 2019, 5(1), 61-67; https://doi.org/10.18383/j.tom.2018.00029
Submission received: 5 December 2018 / Revised: 9 January 2019 / Accepted: 6 February 2019 / Published: 1 March 2019
Versions Notes

Abstract

Accuracy and precision of quantitative imaging (QI) metrics should be assessed in real time in each patient during a clinical trial to support QI-based decision-making. We developed a framework for real-time quantitative assessment of QI metrics and evaluated accuracy and precision of dynamic contrast-enhanced (DCE)-magnetic resonance imaging (MRI)–derived blood volume (BV) in a clinical trial for head and neck cancers. Patients underwent DCE-MRI before and after 2 weeks of radiation therapy (2wkRT). A mean as a reference value and a repeatability coefficient (RC) of BV values established from n patients in cerebellum volumes of interest (VOIs), which were normal and affected little by therapy, served as accuracy and precision measurements. The BV maps of a new patient were called accurate and precise if the values in cerebellum VOIs and the difference between the 2 scans agreed with the respective mean and RC with 95% confidence. The new data could be used to update reference values. Otherwise, the data were flagged for further evaluation before use in the trial. BV maps from 62 patients enrolled on the trial were evaluated. Mean BV values were 2.21 (±0.14) mL/100 g pre-RT and 2.22 (±0.17) mL/100 g at 2wkRT; relative RC was 15.9%. The BV maps from 3 patients were identified to be inaccurate and imprecise before use in the clinical trial. Our framework of real-time quantitative assessment of QI metrics during a clinical trial can be translated to different QI metrics and organ-sites for supporting QI-based decision-making that warrants success of a clinical trial.
Keywords: quantitative imaging; repeatability; real-time assessment; dynamic contrast enhanced MRI; blood volume; head and neck cancer quantitative imaging; repeatability; real-time assessment; dynamic contrast enhanced MRI; blood volume; head and neck cancer

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MDPI and ACS Style

Aryal, M.P.; Lee, C.; Hawkins, P.G.; Chapman, C.; Eisbruch, A.; Mierzwa, M.; Cao, Y. Real-Time Quantitative Assessment of Accuracy and Precision of Blood Volume Derived from DCE-MRI in Individual Patients during a Clinical Trial. Tomography 2019, 5, 61-67. https://doi.org/10.18383/j.tom.2018.00029

AMA Style

Aryal MP, Lee C, Hawkins PG, Chapman C, Eisbruch A, Mierzwa M, Cao Y. Real-Time Quantitative Assessment of Accuracy and Precision of Blood Volume Derived from DCE-MRI in Individual Patients during a Clinical Trial. Tomography. 2019; 5(1):61-67. https://doi.org/10.18383/j.tom.2018.00029

Chicago/Turabian Style

Aryal, Madhava P., Choonik Lee, Peter G. Hawkins, Christina Chapman, Avraham Eisbruch, Michelle Mierzwa, and Yue Cao. 2019. "Real-Time Quantitative Assessment of Accuracy and Precision of Blood Volume Derived from DCE-MRI in Individual Patients during a Clinical Trial" Tomography 5, no. 1: 61-67. https://doi.org/10.18383/j.tom.2018.00029

APA Style

Aryal, M. P., Lee, C., Hawkins, P. G., Chapman, C., Eisbruch, A., Mierzwa, M., & Cao, Y. (2019). Real-Time Quantitative Assessment of Accuracy and Precision of Blood Volume Derived from DCE-MRI in Individual Patients during a Clinical Trial. Tomography, 5(1), 61-67. https://doi.org/10.18383/j.tom.2018.00029

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