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Magnetic Nanoparticle-Based Drug Delivery Approaches for Preventing and Treating Biofilms in Cystic Fibrosis

1
Department of Pharmacology & Therapeutics, School of Biomedical Sciences, Faculty of Medicine, Dentistry and Health Sciences, The University of Melbourne, Parkville, VIC 3010, Australia
2
Department of Ophthalmology, Maimonides Biomedical Research Institute of Cordoba (IMIBIC), Reina Sofia University Hospital, University of Cordoba, 14004 Cordoba, Spain
*
Authors to whom correspondence should be addressed.
Magnetochemistry 2020, 6(4), 72; https://doi.org/10.3390/magnetochemistry6040072
Received: 9 November 2020 / Revised: 9 December 2020 / Accepted: 14 December 2020 / Published: 16 December 2020
(This article belongs to the Special Issue Magnetic Nanoparticles 2020)
Biofilm-associated infections pose a huge burden on healthcare systems worldwide, with recurrent lung infections occurring due to the persistence of biofilm bacteria populations. In cystic fibrosis (CF), thick viscous mucus acts not only as a physical barrier, but also serves as a nidus for infection. Increased antibiotic resistance in the recent years indicates that current therapeutic strategies aimed at biofilm-associated infections are “failing”, emphasizing the need to develop new and improved drug delivery systems with higher efficacy and efficiency. Magnetic nanoparticles (MNPs) have unique and favourable properties encompassing biocompatibility, biodegradability, magnetic and heat-mediated characteristics, making them suitable drug carriers. Additionally, an external magnetic force can be applied to enhance drug delivery to target sites, acting as “nano-knives”, cutting through the bacterial biofilm layer and characteristically thick mucus in CF. In this review, we explore the multidisciplinary approach of using current and novel MNPs as vehicles of drug delivery. Although many of these offer exciting prospects for future biofilm therapeutics, there are also major challenges of this emerging field that need to be addressed. View Full-Text
Keywords: magnetic nanoparticles; drug delivery; biofilms; antibiotic resistance; bacterial infection magnetic nanoparticles; drug delivery; biofilms; antibiotic resistance; bacterial infection
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MDPI and ACS Style

Tan, M.; Reyes-Ortega, F.; Schneider-Futschik, E.K. Magnetic Nanoparticle-Based Drug Delivery Approaches for Preventing and Treating Biofilms in Cystic Fibrosis. Magnetochemistry 2020, 6, 72. https://doi.org/10.3390/magnetochemistry6040072

AMA Style

Tan M, Reyes-Ortega F, Schneider-Futschik EK. Magnetic Nanoparticle-Based Drug Delivery Approaches for Preventing and Treating Biofilms in Cystic Fibrosis. Magnetochemistry. 2020; 6(4):72. https://doi.org/10.3390/magnetochemistry6040072

Chicago/Turabian Style

Tan, Marsha, Felisa Reyes-Ortega, and Elena K. Schneider-Futschik 2020. "Magnetic Nanoparticle-Based Drug Delivery Approaches for Preventing and Treating Biofilms in Cystic Fibrosis" Magnetochemistry 6, no. 4: 72. https://doi.org/10.3390/magnetochemistry6040072

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