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Identification of Cryptic Species of Four Candida Complexes in a Culture Collection

1
Microbiology Research Institute, Universidad Nacional Autónoma de Honduras, Tegucigalpa 11101, Honduras
2
Instituto Hondureño de Seguridad Social, Tegucigalpa 11101, Honduras
*
Author to whom correspondence should be addressed.
J. Fungi 2019, 5(4), 117; https://doi.org/10.3390/jof5040117
Received: 23 November 2019 / Revised: 13 December 2019 / Accepted: 15 December 2019 / Published: 17 December 2019
Candida spp. are one of the most common causes of fungal infections worldwide. The taxonomy of Candida is controversial and has undergone recent changes due to novel genetically related species. Therefore, some complexes of cryptic species have been proposed. In clinical settings, the correct identification of Candida species is relevant since some species are associated with high resistance to antifungal drugs and increased virulence. This study aimed to identify the species of four Candida complexes (C. albicans, C. glabrata, C. parapsilosis, and C. haemulonii) by molecular methods. This is the first report of six cryptic Candida species in Honduras: C. dubliniensis, C. africana, C. duobushaemulonii, C. orthopsilosis, and C. metapsilosis, and it is also the first report of the allele hwp1-2 of C. albicans sensu stricto. It was not possible to demonstrate the existence of C. auris among the isolates of the C. haemulonii complex. We also propose a simple method based on PCR-RFLP for the discrimination of the multi-resistant pathogen C. auris within the C. haemulonii complex. View Full-Text
Keywords: Candida spp.; cryptic species; Honduras; PCR-RFLP; hwp1 gene; gpi gene; C. auris Candida spp.; cryptic species; Honduras; PCR-RFLP; hwp1 gene; gpi gene; C. auris
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MDPI and ACS Style

Fontecha, G.; Montes, K.; Ortiz, B.; Galindo, C.; Braham, S. Identification of Cryptic Species of Four Candida Complexes in a Culture Collection. J. Fungi 2019, 5, 117.

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