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Open AccessCase Report

Sinus Bradycardia Associated with Remdesivir Treatment in COVID-19: A Case Report and Literature Review

1
Department of Internal Medicine, University Hospital of Ioannina, 45110 Ioannina, Greece
2
Department of Cardiology, University Hospital of Ioannina, 45110 Ioannina, Greece
*
Author to whom correspondence should be addressed.
J. Cardiovasc. Dev. Dis. 2021, 8(2), 18; https://doi.org/10.3390/jcdd8020018
Received: 14 January 2021 / Accepted: 10 February 2021 / Published: 12 February 2021
Background: Although remdesivir treatment is widely used during the pandemic coronavirus disease 2019 (COVID-19), there is scarce evidence regarding its cardiac side effects. Case presentation: We report the case of a 36-year-old male hospitalized due to severe COVID-19 symptoms. He presented with a 10-day history of fever (up to 39.7 °C), productive cough, hemoptysis, fatigue, myalgias and hypoxemia. The patient received supplemental oxygen, dexamethasone, remdesivir and empirical antibiotic treatment according to protocol. Asymptomatic sinus bradycardia developed on hospital day 3 (namely, heart rate 39/min compared to 92/min on admission). Secondary causes of bradycardia were excluded based on the absence of relevant evidence from laboratory work-up and echocardiographic examination. The patient’s rhythm restored to normal 9 days after the discontinuation of remdesivir. Conclusions: Considering the frequent use of remdesivir in patients with COVID-19, physicians should be aware of this possible adverse event. View Full-Text
Keywords: SARS-CoV-2; COVID-19; remdesivir; bradycardia; arrhythmia SARS-CoV-2; COVID-19; remdesivir; bradycardia; arrhythmia
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MDPI and ACS Style

Barkas, F.; Styla, C.-P.; Bechlioulis, A.; Milionis, H.; Liberopoulos, E. Sinus Bradycardia Associated with Remdesivir Treatment in COVID-19: A Case Report and Literature Review. J. Cardiovasc. Dev. Dis. 2021, 8, 18. https://doi.org/10.3390/jcdd8020018

AMA Style

Barkas F, Styla C-P, Bechlioulis A, Milionis H, Liberopoulos E. Sinus Bradycardia Associated with Remdesivir Treatment in COVID-19: A Case Report and Literature Review. Journal of Cardiovascular Development and Disease. 2021; 8(2):18. https://doi.org/10.3390/jcdd8020018

Chicago/Turabian Style

Barkas, Fotios; Styla, Chrysoula-Paraskevi; Bechlioulis, Aris; Milionis, Haralampos; Liberopoulos, Evangelos. 2021. "Sinus Bradycardia Associated with Remdesivir Treatment in COVID-19: A Case Report and Literature Review" J. Cardiovasc. Dev. Dis. 8, no. 2: 18. https://doi.org/10.3390/jcdd8020018

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