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Open AccessArticle

Multiple Regression Analysis and Frequent Itemset Mining of Electronic Medical Records: A Visual Analytics Approach Using VISA_M3R3

1
Insight Lab, Western University, London, ON N6A 3K7, Canada
2
Department of Medicine, Epidemiology and Biostatistics, Western University, London, ON N6A 3K7, Canada
3
ICES, London, ON N6A 3K7, Canada
*
Author to whom correspondence should be addressed.
Received: 20 February 2020 / Revised: 16 March 2020 / Accepted: 26 March 2020 / Published: 29 March 2020
(This article belongs to the Special Issue Data Quality and Data Access for Research)
Medication-induced acute kidney injury (AKI) is a well-known problem in clinical medicine. This paper reports the first development of a visual analytics (VA) system that examines how different medications associate with AKI. In this paper, we introduce and describe VISA_M3R3, a VA system designed to assist healthcare researchers in identifying medications and medication combinations that associate with a higher risk of AKI using electronic medical records (EMRs). By integrating multiple regression models, frequent itemset mining, data visualization, and human-data interaction mechanisms, VISA_M3R3 allows users to explore complex relationships between medications and AKI in such a way that would be difficult or sometimes even impossible without the help of a VA system. Through an analysis of 595 medications using VISA_M3R3, we have identified 55 AKI-inducing medications, 24,212 frequent medication groups, and 78 medication groups that are associated with AKI. The purpose of this paper is to demonstrate the usefulness of VISA_M3R3 in the investigation of medication-induced AKI in particular and other clinical problems in general. Furthermore, this research highlights what needs to be considered in the future when designing VA systems that are intended to support gaining novel and deep insights into massive existing EMRs. View Full-Text
Keywords: visual analytics; multivariable regression; frequent itemset mining; interactive visualization; medication-associated acute kidney injury; electronic medical records; human-data interaction visual analytics; multivariable regression; frequent itemset mining; interactive visualization; medication-associated acute kidney injury; electronic medical records; human-data interaction
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Abdullah, S.S.; Rostamzadeh, N.; Sedig, K.; Garg, A.X.; McArthur, E. Multiple Regression Analysis and Frequent Itemset Mining of Electronic Medical Records: A Visual Analytics Approach Using VISA_M3R3. Data 2020, 5, 33.

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