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Bioengineering 2018, 5(4), 100; https://doi.org/10.3390/bioengineering5040100

Decellularized Human Umbilical Artery Used as Nerve Conduit

1
Hellenic Cord Blood Bank, Biomedical Research Foudation Academy of Athens, 4 Soranou Ephessiou Street, 11527 Athens, Greece
2
Center of Clinical, Experimental Surgery and Translational Research, Biomedical Research Foundation of the Academy of Athens, 4 Soranou Ephessiou Street, 11527 Athens, Greece
3
Second Department of Propaedeutic Surgery, University of Athens, Medical School, “Laiko” General Hospital 17 Agios Thomas Street, 11527 Athens, Greece
*
Author to whom correspondence should be addressed.
Received: 28 September 2018 / Revised: 8 November 2018 / Accepted: 16 November 2018 / Published: 21 November 2018
(This article belongs to the Special Issue Stem Cell and Biologic Scaffold Engineering)
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Abstract

Treatment of injuries to peripheral nerves after a segmental defect is one of the most challenging surgical problems. Despite advancements in microsurgical techniques, complete recovery of nerve function after repair has not been achieved. The purpose of this study was to evaluate the use of the decellularized human umbilical artery (hUA) as nerve guidance conduit. A segmental peripheral nerve injury was created in 24 Sprague–Dawley rats. The animals were organized into two experimental groups with different forms of repair: decellularized hUA (n = 12), and autologous nerve graft (n = 12). Sciatic faction index and gastrocnemius muscle values were calculated for functional recovery evaluation. Nerve morphometry was used to analyze nerve regeneration. Results showed that decellularized hUAs after implantation were rich in nerve fibers and characterized by improved Sciatic Functional index (SFI) values. Decellularized hUA may support elongation and bridging of the 10 mm nerve gap. View Full-Text
Keywords: umbilical arteries; nerve regeneration; nerve conduit umbilical arteries; nerve regeneration; nerve conduit
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Gontika, I.; Katsimpoulas, M.; Antoniou, E.; Kostakis, A.; Stavropoulos-Giokas, C.; Michalopoulos, E. Decellularized Human Umbilical Artery Used as Nerve Conduit. Bioengineering 2018, 5, 100.

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