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Medicines 2018, 5(1), 19; https://doi.org/10.3390/medicines5010019

Current and Future Applications of Biomedical Engineering for Proteomic Profiling: Predictive Biomarkers in Neuro-Traumatology

1
Department of Neurosurgery, Toronto Western Hospital, University of Toronto, Toronto, ON M5T 2S8, Canada
2
School of Medicine, University of Cagliari, 09124 Cagliari, Italy
3
School of Medicine, Aristotle University of Thessaloniki, 54623 Thessaloniki, Greece
4
National Hospital for Neurology and Neurosurgery, University College London, London WC1N 3BG, UK
5
Fondazione IRCCS IstitutoNeurologico “Carlo Besta”, 20133 Milano, Italy
6
Division of Neurosurgery, University of Strasbourg, 67000 Strasbourg, France
7
Brain and Mind Institute, Physics & Astronomy Department, Western University, London, ON N6A 3K7, Canada
8
John Radcliffe Hospital, Oxford University, Oxford OX3 9DU, UK
*
Author to whom correspondence should be addressed.
Received: 31 December 2017 / Revised: 29 January 2018 / Accepted: 30 January 2018 / Published: 5 February 2018
(This article belongs to the Special Issue New Innovations in Biomedical Engineering)
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Abstract

This systematic review aims to summarize the impact of nanotechnology and biomedical engineering in defining clinically meaningful predictive biomarkers in patients with traumatic brain injury (TBI), a critical worldwide health problem with an estimated 10 billion people affected annually worldwide. Data were collected through a review of the existing English literature performed on Scopus, MEDLINE, MEDLINE in Process, EMBASE, and/or Cochrane Central Register of Controlled Trials. Only experimental articles revolving around the management of TBI, in which the role of new devices based on innovative discoveries coming from the field of nanotechnology and biomedical engineering were highlighted, have been included and analyzed in this study. Based on theresults gathered from this research on innovative methods for genomics, epigenomics, and proteomics, their future application in this field seems promising. Despite the outstanding technical challenges of identifying reliable biosignatures for TBI and the mixed nature of studies herein described (single cells proteomics, biofilms, sensors, etc.), the clinical implementation of those discoveries will allow us to gain confidence in the use of advanced neuromonitoring modalities with a potential dramatic improvement in the management of those patients. View Full-Text
Keywords: traumatic brain injury; biomarkers; proteomics; microRNA; mass spectroscopy traumatic brain injury; biomarkers; proteomics; microRNA; mass spectroscopy
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
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Ganau, M.; Syrmos, N.; Paris, M.; Ganau, L.; Ligarotti, G.K.; Moghaddamjou, A.; Chibbaro, S.; Soddu, A.; Ambu, R.; Prisco, L. Current and Future Applications of Biomedical Engineering for Proteomic Profiling: Predictive Biomarkers in Neuro-Traumatology. Medicines 2018, 5, 19.

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