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Open AccessReview

Early Diagnosis on Oral and Potentially Oral Malignant Lesions: A Systematic Review on the VELscope® Fluorescence Method

1
Department of Biomedical and Dental Sciences, Morphological and Functional Images, University of Messina, Policlinico G. Martino, 98100 Messina, Italy
2
Multidisciplinary Department of Medical-Surgical and Dental Specialties, Second University of Naples, 34109 Naples, Italy
3
Department of Clinical and Experimental Medicine, University of Foggia, 71122 Foggia, Italy
4
Department of Maxillofacial Surgery, Loma Linda University, Loma Linda, CA 92354, USA
5
Department of General Surgery and Medical-Surgery Specialities, University of Catania, 95100 Catania CT, Italy
*
Author to whom correspondence should be addressed.
Authors contributed equally.
Dent. J. 2019, 7(3), 93; https://doi.org/10.3390/dj7030093
Received: 17 July 2019 / Revised: 15 August 2019 / Accepted: 20 August 2019 / Published: 4 September 2019
(This article belongs to the Special Issue Oral Cancer: Diagnosis and Treatment)
The fluorescence method is an innovative technique used by pathologists for examining body mucosa, and for the abnormalities tissue screening, potentially leading to the earlier discovery of pre-cancer, cancer or other disease processes. The early detection is one of the best mechanisms for enabling treatment success, increasing survival rates and maintaining a high quality of life. The purpose of this review is to evaluate the clinical efficiency of this diagnostic tool applied to the oral cavity (VELscope®). A literature systematic review has been performed. The initial research provided 53 results after applying the inclusion and exclusion criteria, and after a manual screening of the abstracts by the authors, only 25 results were eligible for review. The results and data contained in all the researches, no older than 10 years, were manually evaluated, and provided useful information on this diagnostic method. The VELscope® mean value about sensitivity and specificity resulted of 70.19% and 65.95%, respectively, by results analysis, but despite this some studies disagree about its clinical effectiveness, and this diagnostic method is still much debated in scientific and clinical medical literature. Surely being able to have efficient and effective tools from this point of view could help the clinician in the diagnosis, and also make timelier the pharmacological or surgical therapy, improving the quality of life of the patient, and in some cases guaranteeing a longer survival term. View Full-Text
Keywords: oral cancer; oral neoplasms; precancerous conditions; optical imaging; oral surgery; quality of life; diagnostic techniques and procedures oral cancer; oral neoplasms; precancerous conditions; optical imaging; oral surgery; quality of life; diagnostic techniques and procedures
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Cicciù, M.; Cervino, G.; Fiorillo, L.; D’Amico, C.; Oteri, G.; Troiano, G.; Zhurakivska, K.; Lo Muzio, L.; Herford, A.S.; Crimi, S.; Bianchi, A.; Di Stasio, D.; Rullo, R.; Laino, G.; Laino, L. Early Diagnosis on Oral and Potentially Oral Malignant Lesions: A Systematic Review on the VELscope® Fluorescence Method. Dent. J. 2019, 7, 93.

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