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Dermatopathology, Volume 11, Issue 4

2024 December - 15 articles

Cover Story: TRPS1 (Tricho-rhino-phalangeal syndrome 1) is a gene encoding for a protein used as a sensitive immunohistochemical marker of breast carcinomas. It is also expressed by a variety of primary cutaneous tumors, mostly of adnexal origin. We studied the immunohistochemical expression of TRPS1 in 72 cutaneous metastatic tumors from the breast and other origins in order to assess its diagnostic usefulness. TRPS1 was strongly expressed by the vast majority of metastatic breast carcinomas, and less strongly by a smaller percentage of other metastases, namely from the lung, the female genital tract and the kidney. Most metastases from the digestive tract were completely negative. Although TRPS1 is not absolutely specific or sensitive for a particular primary, it can be added to a panel of other markers when investigating the origin of a cutaneous metastasis. View this paper
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Articles (15)

  • Article
  • Open Access
1,539 Views
6 Pages

The diagnostic utility of immunohistochemistry on paraffin-embedded sections in bullous disorders is useful when frozen tissue is not available. In pemphigus vulgaris and pemphigus foliaceus, an intercellular lace-like staining pattern of IgG4 on les...

  • Article
  • Open Access
3 Citations
2,912 Views
10 Pages
Dermatopathology2024, 11(4), 364-373;https://doi.org/10.3390/dermatopathology11040039 
(registering DOI)

12 December 2024

PRAME (PReferentially expressed Antigen in MElanoma) is a tumor-associated antigen first identified in tumor-reactive T-cell clones derived from a patient with metastatic melanoma. Immunohistochemistry (IHC) for PRAME is useful for diagnostic purpose...

  • Case Report
  • Open Access
2 Citations
3,028 Views
10 Pages

A Rare Case of a Malignant Proliferating Trichilemmal Tumor: A Molecular Study Harboring Potential Therapeutic Significance and a Review of Literature

  • Mokhtar H. Abdelhammed,
  • Hanna Siatecka,
  • A. Hafeez Diwan,
  • Christie J. Finch,
  • Angela D. Haskins,
  • David J. Hernandez and
  • Ya Xu

Malignant proliferating trichilemmal tumors (MPTTs), arising from the external root sheath of hair follicles, are exceptionally rare, with limited documentation of their genetic alterations. We present a case of a 64-year-old African American woman w...

  • Case Report
  • Open Access
3,026 Views
6 Pages

Digital papillary adenocarcinoma (DPAC) is a rare, low-grade sweat gland carcinoma primarily found on the hands, fingers, or toes and predominantly affecting males. Distinguishing DPAC from benign sweat gland tumors can be challenging. We present the...

  • Case Report
  • Open Access
1 Citations
1,545 Views
6 Pages

Atypical Presentation of Spindle Cell Lipoma in a Young Male with a History of Malignant Melanoma

  • Ty Theriot,
  • John David Cattar,
  • Lacey Falgout,
  • Nicholas Culotta and
  • Christopher Haas

Spindle cell lipoma (SCL) is a benign adipocytic tumor usually found in the subcutis of the posterior neck, upper back, and shoulder, predominantly in middle-aged males. This case report describes an atypical presentation of SCL in a 26-year-old male...

  • Review
  • Open Access
4 Citations
2,628 Views
9 Pages

“Chasing Rainbows” Beyond Kaposi Sarcoma’s Dermoscopy: A Mini-Review

  • Emmanouil Karampinis,
  • Olga Toli,
  • Georgia Pappa,
  • Anna Vardiampasi,
  • Melpomeni Theofili,
  • Efterpi Zafiriou,
  • Mattheos Bobos,
  • Aimilios Lallas,
  • Elizabeth Lazaridou and
  • Zoe Apalla
  • + 1 author

The dermoscopic rainbow pattern (RP), also known as polychromatic pattern, is characterized by a multicolored appearance, resulting from the dispersion of polarized light as it penetrates various tissue components. Its separation into different wavel...

  • Case Report
  • Open Access
1,215 Views
3 Pages

Akatsuki disease (also known as pomade crust) is characterized by skin lesions resulting from inadequate skin hygiene. It is sometimes influenced by underlying psychological factors. Akatsuki disease sometimes mimics cutaneous horn or skin cancer. Ho...

  • Article
  • Open Access
2 Citations
3,046 Views
15 Pages

Image-Guided Radiation Therapy Is Equally Effective for Basal and Squamous Cell Carcinoma

  • Erin M. McClure,
  • Clay J. Cockerell,
  • Stephen Hammond,
  • Evelyn S. Marienberg,
  • Bobby N. Koneru,
  • Jon Ward and
  • Jeffrey B. Stricker

Non-melanoma skin cancers (NMSCs), including basal cell carcinoma (BCC) and squamous cell carcinoma (SCC), are highly prevalent and a significant cause of morbidity. Image-guided superficial radiation therapy (IGSRT) uses integrated high-resolution d...

  • Article
  • Open Access
1,818 Views
12 Pages

Background: Tumor collision is a rare event, with an estimated incidence of 0.0017%. Seborrheic keratosis, melanocytic nevi, and basal cell carcinoma (BCC) are by far the most common entities involved in collisions. Most authors consider collision to...

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Dermatopathology - ISSN 2296-3529