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Volume 9
Issue 4
10.18683/germs.2019.1174
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Article

Inverse Association Between Helicobacter pylori Infection and Childhood Asthma in Greece: A Case-Control Study

by
Christina Tsigalou
1,
Theocharis G. Konstantinidis
1,*,
Dimitrios Cassimos
2,
Alexandros Karvelas
1,
Anastasia Grapsa
1,
Aggelos Tsalkidis
2,
Maria Panopoulou
1 and
Athanasios Tsakris
3
1
Laboratory of Microbiology, School of Medicine, Democritus University of Thrace, Dragana, 68100 Alexandroupolis, Greece
2
Department of Pediatrics, University General Hospital of Alexandroupolis, Democritus University of Thrace, Dragana, 68100 Alexandroupolis, Greece
3
Laboratory of Microbiology, Medical School, National and Kapodistrian University of Athens, 75 Mikris Asias, Goudi, 115 27 Athens, Greece
*
Author to whom correspondence should be addressed.
GERMS 2019, 9(4), 182-187; https://doi.org/10.18683/germs.2019.1174
Submission received: 25 July 2019 / Revised: 29 September 2019 / Accepted: 6 November 2019 / Published: 2 December 2019
Versions Notes

Abstract

Introduction: Helicobacter pylori infection is a well-established etiological factor for a variety of diseases such as peptic ulcer and gastric cancer. On the other hand, there is ongoing research suggesting that H. pylori might have a beneficial effect through a pivotal influence in the immunological response especially in asthma. The aim of the current case-control study was to evaluate the prevalence of H. pylori infection in asthmatic children. Methods: Twenty-seven children with exacerbation of persistent asthma, aged 8.6 ± 4.5 years (18 males, 9 females) and 54 age-sex-matched non-asthmatic controls were enrolled. Clinical examination and laboratory investigations were performed. Detection of H. pylori antigen (HpSA) in stool samples was performed by a commercial kit (bioNexia® kit, BioMérieux). Serum specific IgG antibodies were detected by a rapid chromatographic immunoassay (DIAsourceImmunoAssays). Serum IgE concentration was determined by electrochemiluminescence (ECL) (Roche Elecsys) and IgE levels ≥ 90 IU/mL were considered significantly elevated. Results: In 3 (11.1%) of the 27 asthmatic children H. pylori infection (based on both detection of HpSA and specific IgG-Abs) was established, whereas as many as 16 of the 54 (29.6%) non-asthmatic ones were found infected (odds ratio 0.1; 95%CI, 0.039–0.305, p = 0.026). Conclusions: Our findings reveal an inverse relationship between H. pylori infection and children's persistent asthma in Greece.
Keywords: asthma; persistent; Helicobacter pylori; children asthma; persistent; Helicobacter pylori; children

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MDPI and ACS Style

Tsigalou, C.; Konstantinidis, T.G.; Cassimos, D.; Karvelas, A.; Grapsa, A.; Tsalkidis, A.; Panopoulou, M.; Tsakris, A. Inverse Association Between Helicobacter pylori Infection and Childhood Asthma in Greece: A Case-Control Study. GERMS 2019, 9, 182-187. https://doi.org/10.18683/germs.2019.1174

AMA Style

Tsigalou C, Konstantinidis TG, Cassimos D, Karvelas A, Grapsa A, Tsalkidis A, Panopoulou M, Tsakris A. Inverse Association Between Helicobacter pylori Infection and Childhood Asthma in Greece: A Case-Control Study. GERMS. 2019; 9(4):182-187. https://doi.org/10.18683/germs.2019.1174

Chicago/Turabian Style

Tsigalou, Christina, Theocharis G. Konstantinidis, Dimitrios Cassimos, Alexandros Karvelas, Anastasia Grapsa, Aggelos Tsalkidis, Maria Panopoulou, and Athanasios Tsakris. 2019. "Inverse Association Between Helicobacter pylori Infection and Childhood Asthma in Greece: A Case-Control Study" GERMS 9, no. 4: 182-187. https://doi.org/10.18683/germs.2019.1174

APA Style

Tsigalou, C., Konstantinidis, T. G., Cassimos, D., Karvelas, A., Grapsa, A., Tsalkidis, A., Panopoulou, M., & Tsakris, A. (2019). Inverse Association Between Helicobacter pylori Infection and Childhood Asthma in Greece: A Case-Control Study. GERMS, 9(4), 182-187. https://doi.org/10.18683/germs.2019.1174

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