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Open AccessArticle

The Impact of Erythrocytes Injury on Blood Flow in Bionic Arteriole with Stenosis Segment

1
School of Medicine, Tsinghua University, Beijing 100084, China
2
School of Pharmaceutical Sciences, Tsinghua University, Beijing 100084, China
3
School of Mechanical Engineering and Automation, Beijing Advanced Innovation Center for Biomedical Engineering, Beihang University, Beijing 100191, China
4
School of Mechanical Engineering, Shandong University; Key Laboratory of High-efficiency and Clean Mechanical Manufacture at Shandong University, Ministry of Education, Shandong 250061, China
5
First Hospital of Tsinghua University, School of Medicine, Tsinghua University, Beijing 100084, China
6
School of Mechanical Engineering, State Key Laboratory of Tribology, Tsinghua University, Beijing 100084, China
*
Authors to whom correspondence should be addressed.
The two authors contributed equally to this work.
Processes 2019, 7(6), 372; https://doi.org/10.3390/pr7060372
Received: 18 May 2019 / Revised: 2 June 2019 / Accepted: 11 June 2019 / Published: 14 June 2019
(This article belongs to the Special Issue Smart Flow Control Processes in Micro Scale)
Ventricular assist device (VAD) implantation is an effective treatment for patients with end-stage heart failure. However, patients who undergo long-term application of VADs experience a series of VAD-related adverse effects including pump thrombosis, which is induced by rotate impeller-caused blood cell injury and hemolysis. Blood cell trauma-related flow patterns are the key mechanism for understanding thrombus formation. In this study, we established a new method to evaluate the blood cell damage and investigate the real-time characteristics of blood flow patterns in vitro using rheometer and bionic microfluidic devices. The variation of plasma free hemoglobin (PFH) and lactic dehydrogenase (LDH) in the rheometer test showed that high shear stress was the main factor causing erythrocyte membrane injury, while the long-term exposure of high shear stress further aggravated this trauma. Following this rheometer test, the damaged erythrocytes were collected and injected into a bionic microfluidic device. The captured images of bionic microfluidic device tests showed that with the increase of shear stress suffered by the erythrocyte, the migration rate of damaged erythrocyte in bionic microchannel significantly decreased and, meanwhile, aggregation of erythrocyte was clearly observed. Our results indicate that mechanical shear stress caused by erythrocyte injury leads to thrombus formulation and adhesion in arterioles. View Full-Text
Keywords: erythrocyte injury; flow pattern; bionic microfluidic device; thrombosis erythrocyte injury; flow pattern; bionic microfluidic device; thrombosis
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Li, D.; Li, G.; Chen, Y.; Man, J.; Wu, Q.; Zhang, M.; Chen, H.; Zhang, Y. The Impact of Erythrocytes Injury on Blood Flow in Bionic Arteriole with Stenosis Segment. Processes 2019, 7, 372.

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