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Codonopsis laceolata Water Extract Ameliorates Asthma Severity by Inducing Th2 Cells’ and Pulmonary Epithelial Cells’ Apoptosis via NF-κB/COX-2 Pathway

by 1,†, 2,†, 3, 4,5,* and 1,*
1
College of Oriental Medicine, Dongshin University, Naju-si 58245, Korea
2
Department of Pathology, Dongguk University, Goyang-si 10326, Korea
3
Research Institute, Wellphyto Co., Ltd., K1 Office Town 415, Gwangju 69506, Korea
4
College of Pharmacy, Mokpo National University, Muan-gun 58554, Korea
5
Biomedicine, Health & Life Convergence Sciences, BK21 Four, College of Pharmacy, Mokpo National University, Muan-gun 58554, Korea
*
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editor: Odile Francesca Restaino
Processes 2022, 10(7), 1249; https://doi.org/10.3390/pr10071249
Received: 20 May 2022 / Revised: 8 June 2022 / Accepted: 18 June 2022 / Published: 23 June 2022
Asthma is an incurable pulmonary disease with several symptoms, including abnormal breathing, coughing, and sleep apnea, which can lead to death, and the population of asthma patients has been increasing worldwide. There are many adverse effects in current drugs, and thus, we have tried to develop anti-asthmatic agents from natural products such as Codonopsis laceolata. To define the anti-asthmatic effect and the mechanism of Codonopsis laceolata, an animal study was conducted considering different cell counts of BALF, serum IgE levels, morphological changes in the pulmonary system, the Th2 cell transcription factor (GATA-3), and the apoptotic pathway (NF-κB/COX-2). Codonopsis laceolata significantly suppressed the representative asthmatic changes, such as airway remodeling, mucous hypersecretion, epithelial hyperplasia, and inflammatory cell infiltration, in the respiratory system. It suppressed the levels of GATA-3, IL-4, and IL-13. The down-regulation of Th2-related factors, such as GATA-3, IL-4, and IL-13, results from the stimulated apoptosis of Th2 cells and epithelial cells via a decrease in the levels of NF-κB and COX-2. We concluded that Codonopsis laceolata might be a promising anti-asthmatic drug. View Full-Text
Keywords: Codonopsis laceolata; apoptosis; NF-κB/COX-2 pathway; asthma severity Codonopsis laceolata; apoptosis; NF-κB/COX-2 pathway; asthma severity
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MDPI and ACS Style

Bok, S.-H.; Han, K.M.; Boo, H.-O.; Cho, S.-S.; Park, D.-H. Codonopsis laceolata Water Extract Ameliorates Asthma Severity by Inducing Th2 Cells’ and Pulmonary Epithelial Cells’ Apoptosis via NF-κB/COX-2 Pathway. Processes 2022, 10, 1249. https://doi.org/10.3390/pr10071249

AMA Style

Bok S-H, Han KM, Boo H-O, Cho S-S, Park D-H. Codonopsis laceolata Water Extract Ameliorates Asthma Severity by Inducing Th2 Cells’ and Pulmonary Epithelial Cells’ Apoptosis via NF-κB/COX-2 Pathway. Processes. 2022; 10(7):1249. https://doi.org/10.3390/pr10071249

Chicago/Turabian Style

Bok, So-Hyeon, Kang M. Han, Hee-Ock Boo, Seung-Sik Cho, and Dae-Hun Park. 2022. "Codonopsis laceolata Water Extract Ameliorates Asthma Severity by Inducing Th2 Cells’ and Pulmonary Epithelial Cells’ Apoptosis via NF-κB/COX-2 Pathway" Processes 10, no. 7: 1249. https://doi.org/10.3390/pr10071249

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