Healthcare Professionals&rsquo; Attitudes toward Rapid Whole Genome Sequencing in Pediatric Acute Care

Franck, Linda S.; Scheurer-Monaghan, Andrea; Bupp, Caleb P.; Fakhoury, Joseph D.; Hoffmann, Thomas J.; Deshpandey, Manasi; Arenchild, Madison; Dimmock, David P.

doi:10.3390/children9030357

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Healthcare Professionals’ Attitudes toward Rapid Whole Genome Sequencing in Pediatric Acute Care

Linda S. Franck

^1,*

Andrea Scheurer-Monaghan

^2,3,

^4,5

^3,6

⁷,

¹,

⁸

and

David P. Dimmock

⁸

Department of Family Health Care Nursing, University of California, San Francisco, CA 94143, USA

Neonatal Intensive Care, Bronson Children’s Hospital, Kalamazoo, MI 49007, USA

Department of Pediatric and Adolescent Medicine, Western Michigan University Homer Stryker School of Medicine, Kalamazoo, MI 49007, USA

⁴

Medical Genetics, Spectrum Health Helen DeVos Children’s Hospital, Grand Rapids, MI 49503, USA

⁵

Department of Pediatrics and Human Medicine, College of Human Medicine, Michigan State University, Grand Rapids, MI 49503, USA

⁶

Pediatric Hospital Medicine, Bronson Children’s Hospital, Kalamazoo, MI 49007, USA

⁷

Department of Epidemiology and Biostatistics, University of California, San Francisco, CA 94158, USA

⁸

Rady Children’s Institute for Genomic Medicine, San Diego, CA 92123, USA

Author to whom correspondence should be addressed.

Academic Editor: H. Lester Kirchner

Children 2022, 9(3), 357; https://doi.org/10.3390/children9030357

Received: 13 January 2022 / Revised: 24 February 2022 / Accepted: 24 February 2022 / Published: 4 March 2022

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Abstract

We aimed to characterize knowledge and attitudes about rapid whole genome sequencing (rWGS) implementation of a broad constituency of healthcare professionals at hospitals participating in a statewide initiative to implement rWGS for hospitalized neonates and children up to 18 years of age meeting clinical criteria for testing. We surveyed 307 healthcare professionals from eight hospitals about their knowledge and attitudes regarding rWGS. We examined survey internal reliability using exploratory factor analysis and associations between respondent characteristics and attitudes toward rWGS with linear regression. We thematically analyzed free-text responses. Views about rWGS implementation in respondents’ own setting and respondents’ personal capability to implement rWGS were generally neutral (M = 3.44 (SD = 0.74); M = 3.30 (SD = 0.85), respectively). Views about the potential for rWGS in clinical practice were overall positive (M = 4.12 (SD = 0.57)). The degree of positivity of attitudes about rWGS was strongly influenced by perceived knowledge, clinical or non-clinical role, concerns about future insurance coverage for rWGS as a first-tier test, and future adverse impact of genomics health information on patients or families. We identified several actionable factors influencing attitudes toward rWGS of pediatric healthcare professionals. Expanded education and ongoing implementation research are needed for the full potential of rWGS in pediatrics to be realized. View Full-Text

Keywords: genetics; genomics; pediatrics; hospital medicine; medical technology and advancement

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MDPI and ACS Style

Franck, L.S.; Scheurer-Monaghan, A.; Bupp, C.P.; Fakhoury, J.D.; Hoffmann, T.J.; Deshpandey, M.; Arenchild, M.; Dimmock, D.P. Healthcare Professionals’ Attitudes toward Rapid Whole Genome Sequencing in Pediatric Acute Care. Children 2022, 9, 357. https://doi.org/10.3390/children9030357

AMA Style

Franck LS, Scheurer-Monaghan A, Bupp CP, Fakhoury JD, Hoffmann TJ, Deshpandey M, Arenchild M, Dimmock DP. Healthcare Professionals’ Attitudes toward Rapid Whole Genome Sequencing in Pediatric Acute Care. Children. 2022; 9(3):357. https://doi.org/10.3390/children9030357

Chicago/Turabian Style

Franck, Linda S., Andrea Scheurer-Monaghan, Caleb P. Bupp, Joseph D. Fakhoury, Thomas J. Hoffmann, Manasi Deshpandey, Madison Arenchild, and David P. Dimmock. 2022. "Healthcare Professionals’ Attitudes toward Rapid Whole Genome Sequencing in Pediatric Acute Care" Children 9, no. 3: 357. https://doi.org/10.3390/children9030357

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Healthcare Professionals’ Attitudes toward Rapid Whole Genome Sequencing in Pediatric Acute Care

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