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Involvement of mTOR Pathways in Recovery from Spinal Cord Injury by Modulation of Autophagy and Immune Response

Planet of the AAVs: The Spinal Cord Injury Episode

Institute of Experimental Medicine, Czech Academy of Sciences, Vídeňská 1083, 14200 Prague, Czech Republic
Department of Neuroscience, Second Faculty of Medicine, Charles University, 15006 Prague, Czech Republic
Authors to whom correspondence should be addressed.
Academic Editor: George Alexiou
Biomedicines 2021, 9(6), 613;
Received: 7 April 2021 / Revised: 22 May 2021 / Accepted: 25 May 2021 / Published: 28 May 2021
(This article belongs to the Special Issue Advancements in the Treatment of Spinal Cord Injury)
The spinal cord injury (SCI) is a medical and life-disrupting condition with devastating consequences for the physical, social, and professional welfare of patients, and there is no adequate treatment for it. At the same time, gene therapy has been studied as a promising approach for the treatment of neurological and neurodegenerative disorders by delivering remedial genes to the central nervous system (CNS), of which the spinal cord is a part. For gene therapy, multiple vectors have been introduced, including integrating lentiviral vectors and non-integrating adeno-associated virus (AAV) vectors. AAV vectors are a promising system for transgene delivery into the CNS due to their safety profile as well as long-term gene expression. Gene therapy mediated by AAV vectors shows potential for treating SCI by delivering certain genetic information to specific cell types. This review has focused on a potential treatment of SCI by gene therapy using AAV vectors. View Full-Text
Keywords: spinal cord injury; gene therapy; adeno-associated virus; AAV vector spinal cord injury; gene therapy; adeno-associated virus; AAV vector
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MDPI and ACS Style

Stepankova, K.; Jendelova, P.; Machova Urdzikova, L. Planet of the AAVs: The Spinal Cord Injury Episode. Biomedicines 2021, 9, 613.

AMA Style

Stepankova K, Jendelova P, Machova Urdzikova L. Planet of the AAVs: The Spinal Cord Injury Episode. Biomedicines. 2021; 9(6):613.

Chicago/Turabian Style

Stepankova, Katerina, Pavla Jendelova, and Lucia Machova Urdzikova. 2021. "Planet of the AAVs: The Spinal Cord Injury Episode" Biomedicines 9, no. 6: 613.

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