Next Article in Journal
Clinical Assessment of Endothelial Function in Convalescent COVID-19 Patients Undergoing Multidisciplinary Pulmonary Rehabilitation
Next Article in Special Issue
Repetitive Trans Spinal Magnetic Stimulation Improves Functional Recovery and Tissue Repair in Contusive and Penetrating Spinal Cord Injury Models in Rats
Previous Article in Journal
SR-B1, a Key Receptor Involved in the Progression of Cardiovascular Disease: A Perspective from Mice and Human Genetic Studies
Previous Article in Special Issue
Involvement of mTOR Pathways in Recovery from Spinal Cord Injury by Modulation of Autophagy and Immune Response
Review

Planet of the AAVs: The Spinal Cord Injury Episode

1
Institute of Experimental Medicine, Czech Academy of Sciences, Vídeňská 1083, 14200 Prague, Czech Republic
2
Department of Neuroscience, Second Faculty of Medicine, Charles University, 15006 Prague, Czech Republic
*
Authors to whom correspondence should be addressed.
Academic Editor: George Alexiou
Biomedicines 2021, 9(6), 613; https://doi.org/10.3390/biomedicines9060613
Received: 7 April 2021 / Revised: 22 May 2021 / Accepted: 25 May 2021 / Published: 28 May 2021
(This article belongs to the Special Issue Advancements in the Treatment of Spinal Cord Injury)
The spinal cord injury (SCI) is a medical and life-disrupting condition with devastating consequences for the physical, social, and professional welfare of patients, and there is no adequate treatment for it. At the same time, gene therapy has been studied as a promising approach for the treatment of neurological and neurodegenerative disorders by delivering remedial genes to the central nervous system (CNS), of which the spinal cord is a part. For gene therapy, multiple vectors have been introduced, including integrating lentiviral vectors and non-integrating adeno-associated virus (AAV) vectors. AAV vectors are a promising system for transgene delivery into the CNS due to their safety profile as well as long-term gene expression. Gene therapy mediated by AAV vectors shows potential for treating SCI by delivering certain genetic information to specific cell types. This review has focused on a potential treatment of SCI by gene therapy using AAV vectors. View Full-Text
Keywords: spinal cord injury; gene therapy; adeno-associated virus; AAV vector spinal cord injury; gene therapy; adeno-associated virus; AAV vector
Show Figures

Figure 1

MDPI and ACS Style

Stepankova, K.; Jendelova, P.; Machova Urdzikova, L. Planet of the AAVs: The Spinal Cord Injury Episode. Biomedicines 2021, 9, 613. https://doi.org/10.3390/biomedicines9060613

AMA Style

Stepankova K, Jendelova P, Machova Urdzikova L. Planet of the AAVs: The Spinal Cord Injury Episode. Biomedicines. 2021; 9(6):613. https://doi.org/10.3390/biomedicines9060613

Chicago/Turabian Style

Stepankova, Katerina, Pavla Jendelova, and Lucia Machova Urdzikova. 2021. "Planet of the AAVs: The Spinal Cord Injury Episode" Biomedicines 9, no. 6: 613. https://doi.org/10.3390/biomedicines9060613

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop