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Review

SR-B1, a Key Receptor Involved in the Progression of Cardiovascular Disease: A Perspective from Mice and Human Genetic Studies

1
Unidad Clínica y de Investigación en Lípidos y Arteriosclerosis, Instituto de Investigación Sanitaria Aragón (IIS Aragón), Hospital Universitario Miguel Servet, 50009 Zaragoza, Spain
2
Instituto Biofisika (UPV/EHU, CSIC) y Departamento de Bioquímica y Biología Molecular, Universidad del País Vasco UPB/EHU, 48940 Bilbao, Spain
3
Centro de Investigación Biomédica en Red Cardiovascular (CIBERCV), Instituto Salud Carlos III, 28029 Madrid, Spain
4
Departamento de Medicina, Psiquiatría y Dermatología, Universidad de Zaragoza, 50009 Zaragoza, Spain
5
Instituto Aragonés de Ciencias de la Salud (IACS), 50009 Zaragoza, Spain
*
Author to whom correspondence should be addressed.
Academic Editor: Shinji Takai
Biomedicines 2021, 9(6), 612; https://doi.org/10.3390/biomedicines9060612
Received: 26 April 2021 / Revised: 20 May 2021 / Accepted: 24 May 2021 / Published: 27 May 2021
High plasma level of low-density lipoprotein (LDL) is the main driver of the initiation and progression of cardiovascular disease (CVD). Nevertheless, high-density lipoprotein (HDL) is considered an anti-atherogenic lipoprotein due to its role in reverse cholesterol transport and its ability to receive cholesterol that effluxes from macrophages in the artery wall. The scavenger receptor B class type 1 (SR-B1) was identified as the high-affinity HDL receptor, which facilitates the selective uptake of cholesterol ester (CE) into the liver via HDL and is also implicated in the plasma clearance of LDL, very low-density lipoprotein (VLDL) and lipoprotein(a) (Lp(a)). Thus, SR-B1 is a multifunctional receptor that plays a main role in the metabolism of different lipoproteins. The aim of this review is to highlight the association between SR-B1 and CVD risk through mice and human genetic studies. View Full-Text
Keywords: Scavenger receptor B class 1; cardiovascular disease; mice and human genetic studies; high-density lipoprotein; low-density lipoprotein Scavenger receptor B class 1; cardiovascular disease; mice and human genetic studies; high-density lipoprotein; low-density lipoprotein
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MDPI and ACS Style

Gracia-Rubio, I.; Martín, C.; Civeira, F.; Cenarro, A. SR-B1, a Key Receptor Involved in the Progression of Cardiovascular Disease: A Perspective from Mice and Human Genetic Studies. Biomedicines 2021, 9, 612. https://doi.org/10.3390/biomedicines9060612

AMA Style

Gracia-Rubio I, Martín C, Civeira F, Cenarro A. SR-B1, a Key Receptor Involved in the Progression of Cardiovascular Disease: A Perspective from Mice and Human Genetic Studies. Biomedicines. 2021; 9(6):612. https://doi.org/10.3390/biomedicines9060612

Chicago/Turabian Style

Gracia-Rubio, Irene, César Martín, Fernando Civeira, and Ana Cenarro. 2021. "SR-B1, a Key Receptor Involved in the Progression of Cardiovascular Disease: A Perspective from Mice and Human Genetic Studies" Biomedicines 9, no. 6: 612. https://doi.org/10.3390/biomedicines9060612

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