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Global Burden of Alcohol Use Disorders and Alcohol Liver Disease
Review

Alcohol Metabolizing Enzymes, Microsomal Ethanol Oxidizing System, Cytochrome P450 2E1, Catalase, and Aldehyde Dehydrogenase in Alcohol-Associated Liver Disease

1
Division of Gastroenterology and Hepatology, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA
2
Roudebush Veterans Administration Medical Center, Indianapolis, IN 46202, USA
*
Authors to whom correspondence should be addressed.
Biomedicines 2020, 8(3), 50; https://doi.org/10.3390/biomedicines8030050
Received: 24 January 2020 / Revised: 20 February 2020 / Accepted: 29 February 2020 / Published: 4 March 2020
(This article belongs to the Special Issue Alcoholic Liver Disease: Diagnostics and Therapeutics)
Once ingested, most of the alcohol is metabolized in the liver by alcohol dehydrogenase to acetaldehyde. Two additional pathways of acetaldehyde generation are by microsomal ethanol oxidizing system (cytochrome P450 2E1) and catalase. Acetaldehyde can form adducts which can interfere with cellular function, leading to alcohol-induced liver injury. The variants of alcohol metabolizing genes encode enzymes with varied kinetic properties and result in the different rate of alcohol elimination and acetaldehyde generation. Allelic variants of these genes with higher enzymatic activity are believed to be able to modify susceptibility to alcohol-induced liver injury; however, the human studies on the association of these variants and alcohol-associated liver disease are inconclusive. In addition to acetaldehyde, the shift in the redox state during alcohol elimination may also link to other pathways resulting in activation of downstream signaling leading to liver injury. View Full-Text
Keywords: alcohol metabolizing enzyme; cytochrome P450 2E1; and alcohol-associated liver disease alcohol metabolizing enzyme; cytochrome P450 2E1; and alcohol-associated liver disease
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MDPI and ACS Style

Jiang, Y.; Zhang, T.; Kusumanchi, P.; Han, S.; Yang, Z.; Liangpunsakul, S. Alcohol Metabolizing Enzymes, Microsomal Ethanol Oxidizing System, Cytochrome P450 2E1, Catalase, and Aldehyde Dehydrogenase in Alcohol-Associated Liver Disease. Biomedicines 2020, 8, 50. https://doi.org/10.3390/biomedicines8030050

AMA Style

Jiang Y, Zhang T, Kusumanchi P, Han S, Yang Z, Liangpunsakul S. Alcohol Metabolizing Enzymes, Microsomal Ethanol Oxidizing System, Cytochrome P450 2E1, Catalase, and Aldehyde Dehydrogenase in Alcohol-Associated Liver Disease. Biomedicines. 2020; 8(3):50. https://doi.org/10.3390/biomedicines8030050

Chicago/Turabian Style

Jiang, Yanchao, Ting Zhang, Praveen Kusumanchi, Sen Han, Zhihong Yang, and Suthat Liangpunsakul. 2020. "Alcohol Metabolizing Enzymes, Microsomal Ethanol Oxidizing System, Cytochrome P450 2E1, Catalase, and Aldehyde Dehydrogenase in Alcohol-Associated Liver Disease" Biomedicines 8, no. 3: 50. https://doi.org/10.3390/biomedicines8030050

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