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Gastric Cancer Stem Cells: Current Insights into the Immune Microenvironment and Therapeutic Targets

1
Gastrointestinal Cancer Biology, International Research Center of Medical Sciences (IRCMS), Kumamoto University, Kumamoto 860-0811, Japan
2
Department of Gastroenterological Surgery, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Kumamoto 860-8556, Japan
*
Authors to whom correspondence should be addressed.
Biomedicines 2020, 8(1), 7; https://doi.org/10.3390/biomedicines8010007
Received: 25 November 2019 / Revised: 27 December 2019 / Accepted: 4 January 2020 / Published: 6 January 2020
(This article belongs to the Special Issue Gastric Cancer Research: From Basic Science to the Clinic)
Gastric cancer (GC) is a leading cause of cancer-related death worldwide. Cancer stem cells (CSCs) are known to be involved in chemotherapy resistance and the development of metastases. Although CSCs harbor self-renewal and tumorigenic abilities, the immune microenvironment surrounding CSCs provides various factors and supports the maintenance of CSC properties. The current review summarizes the accumulating findings regarding the relationship between the immune microenvironment and gastric CSCs (GCSCs), which will support the possibility of developing novel therapeutic strategies for targeting GCSCs. View Full-Text
Keywords: gastric cancer; gastric cancer stem cell; immune microenvironment; cancer therapy gastric cancer; gastric cancer stem cell; immune microenvironment; cancer therapy
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Fu, L.; Bu, L.; Yasuda, T.; Koiwa, M.; Akiyama, T.; Uchihara, T.; Baba, H.; Ishimoto, T. Gastric Cancer Stem Cells: Current Insights into the Immune Microenvironment and Therapeutic Targets. Biomedicines 2020, 8, 7.

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