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Cytotoxicity of Extracts from New Zealand Surf Clams Against Organ Cancer Cell Lines

1
School of Science, Faculty of Health and Environmental Sciences, Auckland University of Technology, Auckland 1010, New Zealand
2
College of Life Sciences and Oceanography, Shenzhen University, Shenzhen 518071, China
3
School of Interprofessional Health Studies, Faculty of Health and Environmental Sciences, Auckland University of Technology, Auckland 1010, New Zealand
4
Institute of Biomedical Technology, Auckland University of Technology, Auckland 1010, New Zealand
5
College of Food Engineering and Nutritional Science, Shaanxi Normal University, Xi’an 710119, China
*
Author to whom correspondence should be addressed.
Biomedicines 2019, 7(2), 25; https://doi.org/10.3390/biomedicines7020025
Received: 1 February 2019 / Revised: 18 March 2019 / Accepted: 27 March 2019 / Published: 30 March 2019
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Abstract

In this study, we examined the cytotoxic effects of four fractions from three species of New Zealand (NZ) surf clam on four common organ cancer cells. In most cases, a dose- and time-dependent inhibition on the proliferation of the cancer cells was observed. This was most significant in WiDr (colon) cells, where the percentages of viability reduced to as low as 6%, 5%, and 17% (at 1000 µg 72 h) by extracts from Diamond shell, Storm shell, and Tua tua species, respectively. A549 (lung) cells were the least susceptible to the treatment, with viability percentages at 82%, 15%, and 45%, under the same conditions. Induction of caspase-dependent apoptosis and alterations to the cell cycle further supported the observed morphological analysis. The ethanol, petroleum ether, and ethyl acetate fractions of NZ surf clam, rich in lipids and proteins, were more potent than their water-based counterpart. This is the first demonstration where extracts from NZ surf clams show the ability to inhibit the growth and proliferation of cancer cell lines. We suggest that NZ surf clam extracts have the potential to be further studied and developed as candidates for cancer supplementary management/treatment. View Full-Text
Keywords: extract; bioactive; surf clam; organ cancer cells; nutraceutical; New Zealand extract; bioactive; surf clam; organ cancer cells; nutraceutical; New Zealand
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Odeleye, T.; White, W.L.; Lu, J. Cytotoxicity of Extracts from New Zealand Surf Clams Against Organ Cancer Cell Lines. Biomedicines 2019, 7, 25.

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