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Biomedicines 2018, 6(2), 49;

Neural Oscillatory Correlates for Conditioning and Extinction of Fear

Department of Psychology and Neurosciences, Translational Neuromodulation Unit, Leibniz Centre for Working Environment and Human Factors, Technical University Dortmund, 44227 Dortmund, Germany
Institute of Clinical Neuroscience and Medical Psychology, Medical Faculty, Heinrich Heine University, 40225 Dusseldorf, Germany
Departement de Neurochirurgie, Centre Hospitalier Universitaire Montpellier, Université Montpellier, 34000 Montpellier, France
Authors to whom correspondence should be addressed.
Received: 15 March 2018 / Revised: 23 April 2018 / Accepted: 28 April 2018 / Published: 1 May 2018
(This article belongs to the Special Issue Neural Mechanisms of Learning)
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The extinction of conditioned-fear represents a hallmark of current exposure therapies as it has been found to be impaired in people suffering from post-traumatic stress disorder (PTSD) and anxiety. A large body of knowledge focusing on psychophysiological animal and human studies suggests the involvement of key brain structures that interact via neural oscillations during the acquisition and extinction of fear. Consequently, neural oscillatory correlates of such mechanisms appear relevant regarding the development of novel therapeutic approaches to counterbalance abnormal activity in fear-related brain circuits, which, in turn, could alleviate fear and anxiety symptoms. Here, we provide an account of state-of-the-art neural oscillatory correlates for the conditioning and extinction of fear, and also deal with recent translational efforts aimed at fear extinction by neural oscillatory modulation. View Full-Text
Keywords: oscillations; extinction learning; fear conditioning; fear extinction; translational oscillations; extinction learning; fear conditioning; fear extinction; translational

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Trenado, C.; Pedroarena-Leal, N.; Cif, L.; Nitsche, M.; Ruge, D. Neural Oscillatory Correlates for Conditioning and Extinction of Fear. Biomedicines 2018, 6, 49.

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