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Open AccessArticle

Neuroprotective and Anti-Inflammatory Effects of Rhus coriaria Extract in a Mouse Model of Ischemic Optic Neuropathy

Department of Pharmacological and Biomolecular Sciences (DiSFeB), Università degli Studi di Milano, Via Balzaretti, 9-20133 Milan, Italy
Department of Medical Pharmacology and Physiology, University of Missouri, Columbia, MO 65212, USA
EMAN Biodiscoveries Sdn. Bhd., Suite 126, Level 1, EUREKA Complex, University of Science Malaysia (USM), Minden Gelugor 11800, Penang, Malaysia
School of Pharmaceutical Sciences, University of Science Malaysia, Minden Gelugor 11800, Penang, Malaysia
Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, AB T6G 2R3, Canada
Department of Mechanical and Materials Engineering, University of Nebraska-Lincoln, Lincol, NE 68508, USA
John Curtin School of Medical Research, Australian National University, Canberra 2601, Australia
Centre for Natural Product and Angiogenesis Research/Department of Pharmacology, Faculty of Medicine, Quest International University, Ipoh 30250, Malaysia
Authors to whom correspondence should be addressed.
Biomedicines 2018, 6(2), 48;
Received: 16 March 2018 / Revised: 16 April 2018 / Accepted: 19 April 2018 / Published: 23 April 2018
(This article belongs to the Special Issue Anti-inflammatory Activity of Plant Polyphenols)
Modulating oxidative stresses and inflammation can potentially prevent or alleviate the pathological conditions of diseases associated with the nervous system, including ischemic optic neuropathy. In this study we evaluated the anti-neuroinflammatory and neuroprotective activities of Rhus coriaria (R. coriaria) extract in vivo. The half maximal inhibitory concentration (IC50) for DPPH, ABTS and β–carotene were 6.79 ± 0.009 µg/mL, 10.94 ± 0.09 µg/mL, and 6.25 ± 0.06 µg/mL, respectively. Retinal ischemia was induced by optic nerve crush injury in albino Balb/c mice. The anti-inflammatory activity of ethanolic extract of R. coriaria (ERC) and linoleic acid (LA) on ocular ischemia was monitored using Fluorescence Molecular Tomography (FMT). Following optic nerve crush injury, the mice treated with 400 mg/kg of ERC and LA exhibited an 84.87% and 86.71% reduction of fluorescent signal (cathepsin activity) respectively. The results of this study provide strong scientific evidence for the neuroprotective activity of the ERC, identifying LA as one of the main components responsible for the effect. ERC may be useful and worthy of further development for its adjunctive utilization in the treatment of optic neuropathy. View Full-Text
Keywords: neuroprotection; Rhus coriaria; linoleic acid; ischemic optic neuropathy; anti-neuroinflammation neuroprotection; Rhus coriaria; linoleic acid; ischemic optic neuropathy; anti-neuroinflammation
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Khalilpour, S.; Behnammanesh, G.; Suede, F.; Ezzat, M.O.; Muniandy, J.; Tabana, Y.; Ahamed, M.B.K.; Tamayol, A.; Majid, A.M.S.; Sangiovanni, E.; Dell’Agli, M.; Majid, A.S. Neuroprotective and Anti-Inflammatory Effects of Rhus coriaria Extract in a Mouse Model of Ischemic Optic Neuropathy. Biomedicines 2018, 6, 48.

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