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Biomedicines 2018, 6(2), 37; https://doi.org/10.3390/biomedicines6020037

Current Strategies to Enhance Anti-Tumour Immunity

1
Scancell Limited, Academic Department of Clinical Oncology, University of Nottingham, City Hospital Campus, Nottinghamshire NG5 1PB, UK
2
Academic Department of Clinical Oncology, Division of Cancer and Stem Cells, School of Medicine, University of Nottingham, City Hospital Campus, Nottinghamshire NG5 1PB, UK
*
Author to whom correspondence should be addressed.
Received: 21 February 2018 / Revised: 19 March 2018 / Accepted: 21 March 2018 / Published: 23 March 2018
(This article belongs to the Special Issue Dissecting the Immunological Landscape of Human Malignancies)
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Abstract

The interaction of the immune system with cancer is complex, but new approaches are resulting in exciting therapeutic benefits. In order to enhance the immune response to cancer, immune therapies seek to either induce high avidity immune responses to tumour specific antigens or to convert the tumour to a more pro-inflammatory microenvironment. Strategies, including vaccination, oncolytic viruses, and adoptive cell transfer all seek to induce anti-tumour immunity. To overcome the suppressive tumour microenvironment checkpoint inhibitors and modulators of regulatory cell populations have been investigated. This review summarizes the recent advances in immune therapies and discusses the importance of combination therapies in the treatment of cancers. View Full-Text
Keywords: vaccination; oncolytic viruses; adoptive cell transfer; checkpoint inhibition; immune modulators; immune surveillance vaccination; oncolytic viruses; adoptive cell transfer; checkpoint inhibition; immune modulators; immune surveillance
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
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Cook, K.W.; Durrant, L.G.; Brentville, V.A. Current Strategies to Enhance Anti-Tumour Immunity. Biomedicines 2018, 6, 37.

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