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Volume 14
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Correction

Correction: Li et al. Genetic Deficiency of Hyaluronan Synthase 2 in the Developing Limb Mesenchyme Impairs Postnatal Synovial Joint Formation. Biomedicines 2025, 13, 1324

by
Yingcui Li
1,2,*,
Alexander Tress
1,
Peter Maye
2,
Kemar Edwards
1,
Asiona Findletar
1,
Nathaniel A. Dyment
3,
Yu Yamaguchi
4,
David W. Rowe
2,
Gengyun Le-Chan
1,
Sunny S. K. Chan
5 and
Kevin W.-H. Lo
6,*
1
Department of Biology, College of Arts and Sciences, University of Hartford, 200 Bloomfield Avenue, West Hartford, CT 06117, USA
2
Center for Regenerative Medicine and Skeletal Development, University of Connecticut Health Center, Farmington, CT 06032, USA
3
Department of Orthopedic Surgery, University of Pennsylvania, Philadelphia, PA 19104, USA
4
Human Genetics Program, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037, USA
5
Department of Pediatrics, University of Minnesota, Minneapolis, MN 55455, USA
6
Department of Medicine, University of Connecticut Health Center, 263 Farmington Ave, Farmington, CT 06030, USA
*
Authors to whom correspondence should be addressed.
Biomedicines 2026, 14(1), 4; https://doi.org/10.3390/biomedicines14010004
Submission received: 12 December 2025 / Accepted: 12 December 2025 / Published: 19 December 2025
(This article belongs to the Section Biomedical Engineering and Materials)
Browse Figure
Versions Notes

Error in Figure

In the original publication [1], there was a mistake in Figure 1B as published. We recently discovered that one of the images in Figure 1B of our published article was accidentally taken from one of our previous publications during figure assembly. The corrected version of Figure 1B appears below. The authors state that the scientific conclusions are unaffected. This correction was approved by the Academic Editor. The original publication has also been updated.

Reference

  1. Li, Y.; Tress, A.; Maye, P.; Edwards, K.; Findletar, A.; Dyment, N.A.; Yamaguchi, Y.; Rowe, D.W.; Le-Chan, G.; Chan, S.S.K.; et al. Genetic Deficiency of Hyaluronan Synthase 2 in the Developing Limb Mesenchyme Impairs Postnatal Synovial Joint Formation. Biomedicines 2025, 13, 1324. [Google Scholar] [CrossRef] [PubMed]
Biomedicines 14 00004 g001
Figure 1. Limb bud mesenchyme-specific knockout of Has2 induced severe joint defects and impaired the differentiation and formation of articular cartilage. (A,B) Whole mount staining of cartilage and mineralized bone with Alcian Blue and Alizarin Red, respectively, in neonatal day 3 (P3) (A) wildtype Has2fl/fl and (B) mutant Prx1-Cre; Has2Δ/Δ mice. Left to right: whole body, forelimb, hindlimb (0.63×). (C–F) Paraffin sections of the joint surface of 3-week-old (C) wildtype Has2fl/fl and (D) mutant Prx1-Cre; Has2Δ/Δ femurs stained with Safranin-O (red) for proteoglycan accumulation (counterstained with fast green). The wildtype Has2fl/fl femur is capped by a thick layer of articular cartilage, which stains intensely with Safranin-O, while the hyaluronan-deficient femur is capped by a thin layer of tissue that does not stain with Safranin-O, indicating normal articular cartilage is not present (4×) (pointed by black arrow). (E,F) Sections of the tibia joint surface of 3-week-old (P21) (E) wildtype Has2fl/fl and (F) mutant Prx1-Cre; Has2Δ/Δ mice stained with Safranin-O/fast green. In the wildtype Has2fl/fl tibia, a layer of articular cartilage (ac) with round chondrocytes and abundant Safranin-O matrix is present, but the joint surface in the hyaluronan-deficient tibia is covered by a highly cellular tissue with flattened cells and little or no Safranin-O staining, indicating initial articular cartilage differentiation is impaired. Menisci (M) in the hyaluronan-deficient joint also showed no or very little Safranin-O staining. This underscores the importance of Has2 in joint development for different types of chondrocytes (20×).
Figure 1. Limb bud mesenchyme-specific knockout of Has2 induced severe joint defects and impaired the differentiation and formation of articular cartilage. (A,B) Whole mount staining of cartilage and mineralized bone with Alcian Blue and Alizarin Red, respectively, in neonatal day 3 (P3) (A) wildtype Has2fl/fl and (B) mutant Prx1-Cre; Has2Δ/Δ mice. Left to right: whole body, forelimb, hindlimb (0.63×). (C–F) Paraffin sections of the joint surface of 3-week-old (C) wildtype Has2fl/fl and (D) mutant Prx1-Cre; Has2Δ/Δ femurs stained with Safranin-O (red) for proteoglycan accumulation (counterstained with fast green). The wildtype Has2fl/fl femur is capped by a thick layer of articular cartilage, which stains intensely with Safranin-O, while the hyaluronan-deficient femur is capped by a thin layer of tissue that does not stain with Safranin-O, indicating normal articular cartilage is not present (4×) (pointed by black arrow). (E,F) Sections of the tibia joint surface of 3-week-old (P21) (E) wildtype Has2fl/fl and (F) mutant Prx1-Cre; Has2Δ/Δ mice stained with Safranin-O/fast green. In the wildtype Has2fl/fl tibia, a layer of articular cartilage (ac) with round chondrocytes and abundant Safranin-O matrix is present, but the joint surface in the hyaluronan-deficient tibia is covered by a highly cellular tissue with flattened cells and little or no Safranin-O staining, indicating initial articular cartilage differentiation is impaired. Menisci (M) in the hyaluronan-deficient joint also showed no or very little Safranin-O staining. This underscores the importance of Has2 in joint development for different types of chondrocytes (20×).
Biomedicines 14 00004 g001
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MDPI and ACS Style

Li, Y.; Tress, A.; Maye, P.; Edwards, K.; Findletar, A.; Dyment, N.A.; Yamaguchi, Y.; Rowe, D.W.; Le-Chan, G.; Chan, S.S.K.; et al. Correction: Li et al. Genetic Deficiency of Hyaluronan Synthase 2 in the Developing Limb Mesenchyme Impairs Postnatal Synovial Joint Formation. Biomedicines 2025, 13, 1324. Biomedicines 2026, 14, 4. https://doi.org/10.3390/biomedicines14010004

AMA Style

Li Y, Tress A, Maye P, Edwards K, Findletar A, Dyment NA, Yamaguchi Y, Rowe DW, Le-Chan G, Chan SSK, et al. Correction: Li et al. Genetic Deficiency of Hyaluronan Synthase 2 in the Developing Limb Mesenchyme Impairs Postnatal Synovial Joint Formation. Biomedicines 2025, 13, 1324. Biomedicines. 2026; 14(1):4. https://doi.org/10.3390/biomedicines14010004

Chicago/Turabian Style

Li, Yingcui, Alexander Tress, Peter Maye, Kemar Edwards, Asiona Findletar, Nathaniel A. Dyment, Yu Yamaguchi, David W. Rowe, Gengyun Le-Chan, Sunny S. K. Chan, and et al. 2026. "Correction: Li et al. Genetic Deficiency of Hyaluronan Synthase 2 in the Developing Limb Mesenchyme Impairs Postnatal Synovial Joint Formation. Biomedicines 2025, 13, 1324" Biomedicines 14, no. 1: 4. https://doi.org/10.3390/biomedicines14010004

APA Style

Li, Y., Tress, A., Maye, P., Edwards, K., Findletar, A., Dyment, N. A., Yamaguchi, Y., Rowe, D. W., Le-Chan, G., Chan, S. S. K., & Lo, K. W.-H. (2026). Correction: Li et al. Genetic Deficiency of Hyaluronan Synthase 2 in the Developing Limb Mesenchyme Impairs Postnatal Synovial Joint Formation. Biomedicines 2025, 13, 1324. Biomedicines, 14(1), 4. https://doi.org/10.3390/biomedicines14010004

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