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Volume 13
Issue 11
10.3390/biomedicines13112618
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Review

Chemerin and the Gut: From Inflammation to Cancer

by
Elvedin Pljakic
1,†,
Emin Delic
1,2,†,
Irfan Corovic
1,2,*,
Mladen Maksic
3,4,
Dusan Radojevic
3,4,
Isidora Stanisavljevic
1,
Violeta Mladenovic
3,4,
Tomislav Nikolic
3,4,
Lejla Suljic
1,
Emina Corovic Licina
1,
Samir Vucelj
1,
Sabir Sagdati
1,
Kemal Corovic
1,
Nebojsa Igrutinovic
3,4,
Nina Urakovic
3,4,
Haris Plojovic
2,
Selma Habibovic
1,
Ahmo Habibovic
1,
Dusan Popovic
5,6,
Milos Nikolic
7,* and
Marina Jovanovic
3,4add Show full author list remove Hide full author list
1
Center for Molecular Medicine and Stem Cell Research, Faculty of Medical Sciences, University of Kragujevac, Svetozara Markovica 69, 34000 Kragujevac, Serbia
2
General Hospital of Novi Pazar, Generala Zivkovica 1, 36300 Novi Pazar, Serbia
3
Department of Internal Medicine, Faculty of Medical Sciences, University of Kragujevac, Svetozara Markovica 69, 34000 Kragujevac, Serbia
4
Clinic for Internal Medicine, University Clinical Centre Kragujevac, Zmaj Jovina 30, 34000 Kragujevac, Serbia
5
Faculty of Medicine, University of Belgrade, 11000 Belgrade, Serbia; dr.dusan.popovic@gmail.com
6
Department for Gastroenterology and Hepatology, Clinic for Internal Medicine, University Clinical Hospital Center “Dr Dragisa Misovic-Dedinje”, 11000 Belgrade, Serbia
7
Department of Pharmacy, Faculty of Medical Sciences, University of Kragujevac, Svetozara Markovica 69, 34000 Kragujevac, Serbia
*
Authors to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Biomedicines 2025, 13(11), 2618; https://doi.org/10.3390/biomedicines13112618 (registering DOI)
Submission received: 1 September 2025 / Revised: 19 October 2025 / Accepted: 23 October 2025 / Published: 25 October 2025
(This article belongs to the Special Issue The Role of Chemerin in Human Disease—2nd Edition)
Versions Notes

Abstract

Chemerin, encoded by the RARRES2 gene, is an adipokine with potent immunometabolic functions mediated through CMKLR1, GPR1, and CCRL2. Its regulation is tissue- and context-dependent, conferring dual protective and pathogenic roles. In the upper GI tract, chemerin facilitates immune tolerance in Barrett’s adenocarcinoma and promotes invasion in esophageal and gastric cancers. In pancreatic disease, it acts as a biomarker of acute and chronic injury, while modulating β-cell function and carcinogenesis. In the liver, chemerin contributes to NAFLD/NASH pathogenesis with both anti-inflammatory and pro-steatotic actions, predicts prognosis in cirrhosis, and demonstrates tumor-suppressive potential in hepatocellular carcinoma. In IBD, chemerin exacerbates colitis via impaired macrophage polarization, yet protects epithelial antimicrobial defense, underscoring its context-specific biology. Collectively, these findings position chemerin as a versatile regulator bridging metabolic dysfunction, inflammation, and gastrointestinal malignancy, and as a potential candidate for biomarker development and therapeutic intervention.
Keywords: chemerin; adipokine; gastrointestinal diseases; biomarker chemerin; adipokine; gastrointestinal diseases; biomarker

Share and Cite

MDPI and ACS Style

Pljakic, E.; Delic, E.; Corovic, I.; Maksic, M.; Radojevic, D.; Stanisavljevic, I.; Mladenovic, V.; Nikolic, T.; Suljic, L.; Licina, E.C.; et al. Chemerin and the Gut: From Inflammation to Cancer. Biomedicines 2025, 13, 2618. https://doi.org/10.3390/biomedicines13112618

AMA Style

Pljakic E, Delic E, Corovic I, Maksic M, Radojevic D, Stanisavljevic I, Mladenovic V, Nikolic T, Suljic L, Licina EC, et al. Chemerin and the Gut: From Inflammation to Cancer. Biomedicines. 2025; 13(11):2618. https://doi.org/10.3390/biomedicines13112618

Chicago/Turabian Style

Pljakic, Elvedin, Emin Delic, Irfan Corovic, Mladen Maksic, Dusan Radojevic, Isidora Stanisavljevic, Violeta Mladenovic, Tomislav Nikolic, Lejla Suljic, Emina Corovic Licina, and et al. 2025. "Chemerin and the Gut: From Inflammation to Cancer" Biomedicines 13, no. 11: 2618. https://doi.org/10.3390/biomedicines13112618

APA Style

Pljakic, E., Delic, E., Corovic, I., Maksic, M., Radojevic, D., Stanisavljevic, I., Mladenovic, V., Nikolic, T., Suljic, L., Licina, E. C., Vucelj, S., Sagdati, S., Corovic, K., Igrutinovic, N., Urakovic, N., Plojovic, H., Habibovic, S., Habibovic, A., Popovic, D., ... Jovanovic, M. (2025). Chemerin and the Gut: From Inflammation to Cancer. Biomedicines, 13(11), 2618. https://doi.org/10.3390/biomedicines13112618

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