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Antibacterial and Immunomodulatory Properties of Acellular Wharton’s Jelly Matrix

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Biomatériaux et Inflammation en Site Osseux (BIOS) EA 4691, Université de Reims Champagne Ardenne, 51100 Reims, France
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Dentistry Faculty, Université de Reims Champagne Ardenne, 51100 Reims, France
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Pôle Médecine Bucco-Dentaire, Hôpital Maison Blanche, Centre Hospitalier Universitaire de Reims, 51100 Reims, France
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Laboratoire d’Étude des Microstructures et de Mécanique des Matériaux (LEM3)—UMR CNRS 7239, Université de Lorraine, 57070 Metz, France
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Laboratoire de Nanomédecine, Imagerie, Thérapeutique EA 4662, Université Bourgogne Franche-Comté, 25000 Besançon, France
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Laboratoire D’anatomie et Cytologie Pathologique, Centre Hospitalo-Universitaire, Hôpital Robert Debré, 51100 Reims, France
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Plateau Technique URCACyt, Université de Reims Champagne Ardenne, 51100 Reims, France
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Pharmacy Faculty, Université de Reims Champagne Ardenne, 51100 Reims, France
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Authors to whom correspondence should be addressed.
Academic Editor: Stefano Bacci
Biomedicines 2022, 10(2), 227; https://doi.org/10.3390/biomedicines10020227
Received: 9 December 2021 / Revised: 10 January 2022 / Accepted: 17 January 2022 / Published: 21 January 2022
(This article belongs to the Section Immunology and Immunotherapy)
Of all biologic matrices, decellularized tissues have emerged as a promising tool in the field of regenerative medicine. Few empirical clinical studies have shown that Wharton’s jelly (WJ) of the human umbilical cord promotes wound closure and reduces wound-related infections. In this scope, we herein investigated whether decellularized (DC)-WJ could be used as an engineered biomaterial. In comparison with devitalized (DV)-WJ, our results showed an inherent effect of DC-WJ on Gram positive (S. aureus and S. epidermidis) and Gram negative (E. coli and P. aeruginosa) growth and adhesion. Although DC-WJ activated the neutrophils and monocytes in a comparable magnitude to DV-WJ, macrophages modulated their phenotypes and polarization states from the resting M0 phenotype to the hybrid M1/M2 phenotype in the presence of DC-WJ. M1 phenotype was predominant in the presence of DV-WJ. Finally, the subcutaneous implantation of DC-WJ showed total resorption after three weeks of implantation without any sign of foreign body reaction. These significant data shed light on the potential regenerative application of DC-WJ in providing a suitable biomaterial for tissue regenerative medicine and an ideal strategy to prevent wound-associated infections. View Full-Text
Keywords: Wharton’s jelly; decellularization; bioactivity; antibacterial; immunomodulation Wharton’s jelly; decellularization; bioactivity; antibacterial; immunomodulation
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MDPI and ACS Style

Dubus, M.; Scomazzon, L.; Chevrier, J.; Ledouble, C.; Baldit, A.; Braux, J.; Gindraux, F.; Boulagnon, C.; Audonnet, S.; Colin, M.; Rammal, H.; Mauprivez, C.; Kerdjoudj, H. Antibacterial and Immunomodulatory Properties of Acellular Wharton’s Jelly Matrix. Biomedicines 2022, 10, 227. https://doi.org/10.3390/biomedicines10020227

AMA Style

Dubus M, Scomazzon L, Chevrier J, Ledouble C, Baldit A, Braux J, Gindraux F, Boulagnon C, Audonnet S, Colin M, Rammal H, Mauprivez C, Kerdjoudj H. Antibacterial and Immunomodulatory Properties of Acellular Wharton’s Jelly Matrix. Biomedicines. 2022; 10(2):227. https://doi.org/10.3390/biomedicines10020227

Chicago/Turabian Style

Dubus, Marie, Loïc Scomazzon, Julie Chevrier, Charlotte Ledouble, Adrien Baldit, Julien Braux, Florelle Gindraux, Camille Boulagnon, Sandra Audonnet, Marius Colin, Hassan Rammal, Cédric Mauprivez, and Halima Kerdjoudj. 2022. "Antibacterial and Immunomodulatory Properties of Acellular Wharton’s Jelly Matrix" Biomedicines 10, no. 2: 227. https://doi.org/10.3390/biomedicines10020227

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