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Review

DNA Damage Repair: Predictor of Platinum Efficacy in Ovarian Cancer?

1
First Department of Medicine, Laiko General Hospital, School of Medicine, National and Kapodistrian University of Athens, 11527 Athens, Greece
2
Institute of Chemical Biology, National Hellenic Research Foundation, 11635 Athens, Greece
3
2nd Propaedeutic Department of Internal Medicine, Attikon University Hospital, National and Kapodistrian University of Athens, 12462 Athens, Greece
4
Department of Clinical Therapeutics, Alexandra General Hospital, School of Medicine, National and Kapodistrian University of Athens, 11528 Athens, Greece
*
Author to whom correspondence should be addressed.
Academic Editors: Beata Pajak and Anna Jaśkiewicz
Biomedicines 2022, 10(1), 82; https://doi.org/10.3390/biomedicines10010082
Received: 25 November 2021 / Revised: 23 December 2021 / Accepted: 29 December 2021 / Published: 31 December 2021
(This article belongs to the Special Issue Killing It Softly–New Approaches to Overcome Cancer Chemoresistance)
Ovarian cancer (OC) is the seventh most common type of cancer in women worldwide. Treatment for OC usually involves a combination of surgery and chemotherapy with carboplatin and paclitaxel. Platinum-based agents exert their cytotoxic action through development of DNA damage, including the formation of intra- and inter-strand cross-links, as well as single-nucleotide damage of guanine. Although these agents are highly efficient, intrinsic and acquired resistance during treatment are relatively common and remain a major challenge for platinum-based therapy. There is strong evidence to show that the functionality of various DNA repair pathways significantly impacts tumor response to treatment. Various DNA repair molecular components were found deregulated in ovarian cancer, including molecules involved in homologous recombination repair (HRR), nucleotide excision repair (NER), mismatch repair (MMR), non-homologous end-joining (NHEJ), and base excision repair (BER), which can be possibly exploited as novel therapeutic targets and sensitive/effective biomarkers. This review attempts to summarize published data on this subject and thus help in the design of new mechanistic studies to better understand the involvement of the DNA repair in the platinum drugs resistance, as well as to suggest new therapeutic perspectives and potential targets. View Full-Text
Keywords: ovarian cancer; DNA repair; platinum drugs; effective biomarkers; therapeutic targets ovarian cancer; DNA repair; platinum drugs; effective biomarkers; therapeutic targets
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MDPI and ACS Style

Stefanou, D.T.; Souliotis, V.L.; Zakopoulou, R.; Liontos, M.; Bamias, A. DNA Damage Repair: Predictor of Platinum Efficacy in Ovarian Cancer? Biomedicines 2022, 10, 82. https://doi.org/10.3390/biomedicines10010082

AMA Style

Stefanou DT, Souliotis VL, Zakopoulou R, Liontos M, Bamias A. DNA Damage Repair: Predictor of Platinum Efficacy in Ovarian Cancer? Biomedicines. 2022; 10(1):82. https://doi.org/10.3390/biomedicines10010082

Chicago/Turabian Style

Stefanou, Dimitra T., Vassilis L. Souliotis, Roubini Zakopoulou, Michalis Liontos, and Aristotelis Bamias. 2022. "DNA Damage Repair: Predictor of Platinum Efficacy in Ovarian Cancer?" Biomedicines 10, no. 1: 82. https://doi.org/10.3390/biomedicines10010082

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