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  • Case Report
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17 March 2021

Sudden Death from Primary Cerebral Melanoma: Clinical Signs and Pathological Observations

,
,
,
and
1
Legal Medicine Department, A. Cardarelli Hospital, 80131 Naples, Italy
2
Pathology Unit, Mauro Scarlato Hospital, 84018 Scafati, Italy
3
AORN Sant’Anna e San Sebastiano di Caserta, 81100 San Sebastiano, Italy
4
Legal Medicine, Department of Medical, Surgical and Advanced Technologies, “G.F. Ingrassia”, University of Catania, 95123 Catania, Italy
Healthcare2021, 9(3), 341;https://doi.org/10.3390/healthcare9030341
This article belongs to the Special Issue Forensic Science and Legal Medicine: A Multidisciplinary Puzzle!
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Abstract

Primary cerebral tumors rarely provoke sudden death. The incidence is often underestimated with reported frequencies in the range of 0.02 to 2.1% in medicolegal autopsy series. Furthermore, primary cerebral melanoma is an uncommon neoplasm. It represents approximately 1% of all melanoma cases and 0.07% of all brain tumors. This neoplasm is very aggressive, and its annual incidence is about 1 in 10 million people. In the present study, a 20-year-old male was admitted to hospital with vomiting, headache, paresthesia and aggressive behavior. A computed tomography (CT) scan of the head was performed showing a hyperdense nodule in the right parietal lobe with inflammation of the Silvian fissure. A complete autopsy was performed 48 h after death. A blackish material was displayed on the skull base, and posterior fossa. Microscopic examination diagnosed primary brain melanoma. A systematic review of the literature was also performed where no previous analogous cases were found. The forensic pathologist rarely encounters primary cerebral melanoma, and for these reasons, it seemed appropriate to describe this case as presenting aspecific clinical symptoms and leading to sudden unexpected death. Histopathological observations are reported and discussed to explain this surprising sudden death caused by a primary cerebral melanoma.

1. Introduction

Sudden unexpected death due to a primary nervous neoplasm is not frequent in medico-legal activity [1] because the incidence of undiagnosed primary central nervous system tumors has decreased with the emergence of advanced neuroimaging and other improved diagnostic techniques. Occasionally, the forensic pathologist can encounter a cerebral neoplasm that had been undiagnosed or not suspected prior to death. Eberhart et al. [2] observed 11 cases of primary central nervous system tumors resulting in sudden death over a period of 20 years (1980 to 1999). Glioblastomas [3,4,5,6], oligodendragliomas [7], astrocitomas [8], ependymomas [9], extramedullary plasmacytomas [10], colloid cysts of third ventricle [11,12] and meningiomas [13], are reported in the literature to cause sudden death with vague or short-term symptoms and limited healthcare access. Current studies of sudden death from brain tumors concern glioblastoma multiforme or astrocytomas. In the present study, a systematic review of sudden death and brain tumors from 1980 to 2021 was conducted, and it was concluded that although articles had been analyzed over a period of 40 years, there are still few articles today that report this type of death. We found only one case of sudden death associated with melanoma brain metastases [14] and it seemed appropriate to describe the histopathological manifestations of this surprising case of sudden death due to primary cerebral melanoma. Glitza [15], in an autopsy series, identified up 80% of patients with melanoma with metastatic involvement of the central nervous system (CNS); however, while the cerebral metastases of melanoma are often observed, primary cerebral melanoma is very rare. Several histogenetic theories on the origin of meningeal melanocytes have been put forward [16]. It has been postulated that during embryogenesis, leptomeningeal melanocytes coming from the multipotential cells of the neural crest can develop into mesodermal and neural elements. Primary cerebral melanomas develop once melanocytes become neoplastic.
The aim of this study was to present a case report and a systematic review of this rare pathology, in order to improve the overall knowledge of forensic pathologists on sudden death from brain tumors, especially in the case of cerebral melanoma. A complete autopsy, comparing radiological findings and histological presentation, could provide a comprehensive overview of such sudden deaths.

2. Materials and Methods

2.1. Case Description

A 20-year-old male was admitted to hospital with vomiting and headache; he was a cannabis user and cigarette smoker (40 cigarettes a day). He referred paresthesia in the upper limbs, psychomotor agitation and aggressive behavior. The neurological examination pointed out a palpebral ptosis and a right eye ophthalmoplegia including paralysis of the left facial nerve. A CT scan of the brain was performed and showed a hyperdense nodule in the right parietal lobe and along the Sylvian fissure, the leptomeningeal spaces were described as affected by an inflammatory process (Figure 1). Fifteen minutes after the CT scan, he died. The study of the medical record and the sudden onset of symptoms defined death as “sudden”. The accuracy of the autopsy examination, the histological investigation (H&E and immunohistochemistry), attributed his death to a rare form of primary cerebral melanoma.
Figure 1. Pre-mortem CT scan of the brain. The right parietal lobe showed inflammatory processes with a hyperdense nodule.
No ethical committee was required. Written informed consent was obtained from his relatives.

2.2. Autopsy Findings

A complete autopsy was performed 48 h after death. External examination revealed abrasions on the hands and the upper limbs. The autopsy revealed the dura was full of clots. The brain weighed 1550 g and was diffusely swollen. In the subarachnoid space of the fronto-parietal lobes and along the interhemispheric cleavage of the parietal left lobe, some nodular blackish rounded soft formations with blood were observed. Moreover, in the temporal and parietal lobes, similar formations were present (Figure 2). A soft and blackish mass (4.5 × 7 cm) enveloped the brain stem and was spreading to the inferior temporal poles and to the cerebellar lobes. There was no herniation of the temporal lobe, unci or cerebellar tonsils. The section of the brain revealed on edematous soft parenchyma. Blackish soft material present in subarachnoid space of the fronto-parietal right lobe invaded the cerebral cortex. The brain ventricles were filled with blood. From the dorsal face of the brain stem, striae of blackish material invaded the nervous tissue (Figure 3). Blackish material was also present along the venous sinus of the skull base and in the posterior fossa (Figure 4). The internal examination of the other organs was unmarkable.
Figure 2. Brain examination. In the temporal and parietal lobes, some nodular blackish rounded soft formations with blood were observed.
Figure 3. Posterior face of the brain revealed stem striae of blackish material that invaded the nervous tissue.
Figure 4. Skull base-posterior fossa and venous sinus examination showed a blackish material.

2.3. Histological Analysis

During the autopsy, brain samples were collected that were fixed in 10% buffered formalin. After washing, the water was removed, and they were embedded in paraffin. The obtained blocks were cut (4 µm thickness), using a microtome (Dako, Glostrup, Denmark), sectioned, and stored at room temperature. Sections were stained with Hematoxylin and Eosin (H&E) and Von Gieson’s method. The immunohistochemical analysis of the samples was performed through antimelanoma-antibody (HMB45+), Melan A-antibody, CD3-antibody, CD20+-antibody, PenCK-antibody, Ki67+, as suggested by Tosaka et al. [17] for the diagnosis of primary leptomeningeal melanoma. Sections were observed using a Zeiss Axioplan light microscope (Carl Zeiss, Oberkochen, Germany). Subsequently, images were obtained using a Zeiss AxioCam MRc5 digital camera (Carl Zeiss, Oberkochen, Germany). In the present study, the microscopic examination of the brain showed, on the right parietal lobe and in brain-stem tissues, many atypical and pleomorphic cells with voluminous discolored nuclei and melanin-pigment in the cytoplasm. These cells were arranged like a “cordon” or irregularly like a “vortex”. Moreover, a vascular proliferation and spotty hemorrhages were also observed. In the cerebral cortex tissues, edema and ischemic dark neurons, and near them, a lymphocytic and macrophage reaction were seen. The leptomeningeal arteriolar vessels showed clots, partially reorganized. Around them, we observed many pleomorphic and atypical cells with melanin pigment in the cytoplasm (Figure 5).
Figure 5. Histological findings. (a) neoplastic voluminous cells with melanin in the cerebral tissue (E.E. 60×); (b) neoplastic cell population: numerous, voluminous melanoblasts with marked nuclear pleiomorphism; (c) neoplastic cells with melanic pigment antimelanoma-antibody (HMB45 + 200×); (d) neoplastic cell population near a small cerebral artery (E.E. 200×).

3. Systematic Review

A systematic review was conducted according to the PRISMA guidelines [18].
Pubmed and Google Scholar were used as search engines from 1 January 1980 to 1 February 2021 to evaluate the association between sudden death and brain tumor. meSH was used for the following words: (sudden death) AND (primary cerebral tumor).

3.1. Inclusion and Exclusion Criteria

The following exclusion criteria were used: (1) review, (2) articles not in English, (3) animal studies, (4) abstract, (5) editorial, (6) poster, and (7) communications at conferences. The inclusion criteria were as follows: (1) Original Article, (2) Case Report, and (3) Articles in English.

3.2. Quality Assessment and Data Extraction

A.M. and A.P. initially evaluated all the articles, evaluating the title, the abstract, and the whole text. Once, P.G. and M.E. reanalyzed the articles chosen independently. In cases of conflicting opinions between the articles, they were submitted to G.V.

3.3. Characteristics of Eligible Studies

A total of 388 articles were collected (66 from PubMed and 322 from Google Scholar). Of them, 27 duplicates were removed. A total of 339 articles did not meet the inclusion criteria. In conclusion, 22 articles were included in the present systematic review (Figure 6).
Figure 6. Flow diagram illustrating included and excluded studies in this systematic review.

4. Results

Most of the studies were case reports (n. 16), some cases series (n. 4), and a few original articles (n. 2). Most of the tumors related to sudden death were matched with glioblastoma multiform or astrocytomas in the different world health organization (WHO) grades. Other tumors related to sudden death were oligodendrogliomas, gliomas, adenomas, and colloid cysts. The most frequent autopsy findings were cerebral edema, solid tumor mass, and hemorrhagic infarction of surrounding tissue. The most frequent cause of death was due to intracranial hypertension from the tumor; sometimes it was due to hemorrhage caused by the tumor (especially in cases of glioblastoma multiform); only one case was due to respiratory arrest due to the location of the tumor near the center of breathing control (Table 1).
Table 1. summarizes the details of the systematic review.

5. Discussion

Sudden death due to brain tumors has a low incidence and is often underestimated [18]. This systematic review highlights that currently there is no study with a large number of cases of sudden death from brain tumors. Furthermore, most of the case reports report glioblastoma multiforme. This case report is the first to focus on sudden death from cerebral melanoma and it is important that forensic pathologists recognize this cause of sudden death.
Primary cerebral melanoma is a very uncommon neoplasm derived from melanocytes present in the leptomeninges. This pathology, first described by Virchow [32], is very rare, with an annual incidence of approximately 1 in 10 million people [33] and represents about 1% of all melanoma cases and 0.07% of all brain tumors [34]. Indeed, many studies have demonstrated that in central nervous systems (CNS) metastases of melanoma are also frequently present because the melanoma has a high risk of spreading to CNSs. The melanoma cells, in fact, share with vascular cells numerous cell surface molecules; they are highly angiogenic and possess a higher degree of “stemness” than other solid tumors [15]. According to Hayword [35], we can identify a primary cerebral melanoma when the following occur: (a) no malignant melanoma outside the CNS; (b) non-malignant neoplasm in other parts of the CNS; (c) histological validation of melanoma.
Age is also an additional factor to distinguish a primary cerebral melanoma from metastatic melanoma. Primary cerebral melanoma develops primarily in patients under 50 years of age and rarely metastasize to other organs. Metastatic melanomas develop mainly in the elderly, have a rapid clinical course and multiple intracerebral diffusion [36]. In the presented case, no other melanomas were detected at the clinical and forensic examinations of the body; a solitary blackish mass (4 × 7 cm) was observed around the brain stem. Leptomeningeal blackish soft rounded formations in the fronto-parietal lobes were observed and the patient was under 50 years old. The histological observations confirmed, with the immunohistochemical analysis, the diagnosis of melanoma. In addition to the blackish mass observed around the brain stem, we also observed in the subarachnoid space in the right parietal lobe some rounded blackish nodules invading the nervous tissue. We interpreted these modifications as the primitive cerebral melanoma located in the brain stem subarachnoid space, where we found a blackish mass at autopsy. The meningeal vessels of the left parietal lobe were thrombosed and around these vessels we observed many atypical pleomorphic cells with cytoplasmatic melanin pigment; the neoplasm had probably first developed from the leptomeningeal space around the brain stem, and after, spread to the subarachnoid space of the left parietal lobe. In fact, it should be borne in mind also that melanocytes far outnumber leptomeninges of the skull base and cervical cord [37,38] and the most common locations of primary cerebral melanoma are the anterolateral face of the spinal cord and the postero-lateral face of the brain stem [39]. In agreement with this author, primary cerebral melanoma was observed also in the posterior fossa in the cerebellopontine angle [40,41] and Arantes [42] reported 13 cases of primary malignant melanoma derived from the pineal body. Greco Castro [43] observed this neoplasm in the temporal lobe near the Sylvian fissure and Quillo-Olvera [44] reported that the primary cerebral melanoma can be found frequently in the cerebral lobe (53.1%) in the posterior fossa (17.3%) and pineal region (13.6%). We believe that primary cerebral melanoma may occur in any leptomeningeal location, although our reported case is in agreement with the observations of Troya-Castilla. The clinical manifestations are generally non-specific, related to an increased cerebral pressure, or cerebral hemorrhages, or a neurological dysfunction and the early diagnosis of this neoplasm is a very difficult challenge for clinicians [45,46,47,48]. The aggressive behavior, the vague symptoms, and the unspecific neuroimaging make the prognosis of this tumor very difficult [49]. Several studies [50,51] reported a survival of ~4 months from diagnosis of cerebral nervous system melanoma, and once the cancer spreads to the leptomeninges, the overall median survival is generally only 10 weeks [52,53]. In our case, two months after the first symptoms, the patient died. The patient had a history of drug addiction, presenting psychomotor agitation and aggressive behavior, as can be observed in many cerebral neoplasms [54,55,56,57]. Morais described a case of delirium in a patient with brain melanoma metastases [58] and other authors reported headache and diplopia in a 27-year-old man affected by primary meningeal melanocytoma in the anterior cranial fossa [59]. However, we can ascribe the first presented symptoms (headache and vomit) to increased intracranial pressure, probably due to the increased neoplastic mass in the posterior fossa and a subarachnoid hemorrhage. However, the symptoms observed before death (paralysis of the III and VIII cranial nerve) clearly showed a suffering brain stem. The involvement of this important brain structure also explains the sudden death due to an alteration of the hypothalamic cardiovascular regulatory centers. It is well-known that stimulation of the hypothalamus can lead to anatomic cardiovascular disturbances and cardiac arrest [60,61].

6. Conclusions

The surprising case of sudden death stresses the need for a careful analysis in all patients with psychiatric disorders or no-specific neurological signs, especially when these manifestations show-up unexpectedly in a healthy person. Despite the fact that modern genetic [62,63,64], radiological [65,66,67], and therapeutic treatments [68,69,70,71,72,73] have revolutionized the approach to primary cerebral melanoma, autopsy can still provide a useful support in determining the exact location, diffusion, and histological pattern of this neoplasm, and the cause of death. In human beings, melanocyte exists in the uvea, cerebral parenchyma, leptomeninges, and mucous membranes. Primary cerebral melanoma is rare and has an estimated incidence of 0.005 cases per 100,000 and develops in around 1% of all melanoma cases. Brain melanoma metastasis is much more common than primary brain melanoma. Primary brain melanomas originate from melanocytes of the leptomeninges and histopathologically show strongly pigmented cells with prominent nucleoli [74]. Through this systematic review, the present case is the first described in literature in which a primary brain melanoma caused a sudden death. It is, therefore, of crucial importance to report this case to the scientific community.

Author Contributions

Conceptualization, A.M. and A.P.; methodology, P.G.; software, M.E.; validation, G.V., A.M. and A.P.; formal analysis, P.G.; investigation, M.E.; resources, G.V.; data curation, A.M.; writing—original draft preparation, A.P.; writing—review and editing, M.E.; visualization, G.V.; supervision, P.G.; project administration, A.M.; funding acquisition, G.V. All authors have read and agreed to the published version of the manuscript.

Funding

This research received no external funding.

Institutional Review Board Statement

All procedures performed in the study were in accordance with the ethical standards of the institution and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.

Data Availability Statement

All data are included in the main text.

Acknowledgments

The authors thank the Scientific Bureau of the University of Catania for language support.

Conflicts of Interest

The authors declare no conflict of interest.

References

  1. Back, M.; Graham, D.I. Sudden unexplained death in adults caused by intracranial pathology. J. Clin. Pathol. 2002, 55, 44–50. [Google Scholar]
  2. Eberhart, C.G.; Morrison, A.; Gyure, K.A.; Frazier, J.; Smialek, J.E.; Troncoso, J.C. Drecreasing incidence of sudden death due to undiagnosed primary central nervous system tumors. Arch. Pathol. Lab. Med. 2001, 125, 1024–1030. [Google Scholar] [CrossRef] [PubMed]
  3. Matschke, J.; Tsokos, M. Sudden unexpected death due to undiagnosed glioblastoma: Report of three cases and review of the literature. Int. J. Leg. Med. 2005, 119, 280–284. [Google Scholar] [CrossRef]
  4. Gleckman, A.M.; Smith, T.W. Unexpected death from primary posterior fossa tumors. Am. J. Forensic Med. Pathol. 1998, 19, 303–308. [Google Scholar] [CrossRef] [PubMed]
  5. Sutton, J.T.; Cummings, P.M.; Ross, G.W.; Lopes, M.B. Sudden death of a 7-year-old boy due to undiagnosed glioblastoma. Am. J. Forensic Med. Pathol. 2010, 31, 278–280. [Google Scholar] [CrossRef] [PubMed]
  6. Riezzo, I.; Zamparese, R.; Neri, M.; De Stefano, F.; Parente, R.; Pomara, C.; Turillazzi, E.; Ventura, F.; Fineschi, V. Sudden, unexpected death due to glioblastoma: Report of three fatal cases and review of literature. Diagn. Pathol. 2013, 8, 73. [Google Scholar] [CrossRef]
  7. Manousaki, M.; Papadaki, H.; Papavdi, A.; Kranioti, E.F.; Mylonakis, P.; Varakis, S.; Michalodimitrakis, M. Sudden unexpected death from oligodendroglioma: A case report and review of the literature. Am. J. Forensic Med. Pathol. 2011, 32, 336–340. [Google Scholar] [CrossRef] [PubMed]
  8. Vougiouklakis, T.; Mitselou, A.; Agnantis, N.J. Sudden death due to primary intracranial neoplasm—A forensic autopsy study. Anticancer Res. 2006, 26, 2463–2466. [Google Scholar] [PubMed]
  9. Harrison, W.T.; Bouldin, T.; Buckley, A.; Estrada, J.; McLondon, R.; Jansen, K. Sudden unexpected death in a child from anaplastic ependymoma. Am. J. Forensic Med. Pathol. 2019, 40, 275–278. [Google Scholar] [CrossRef] [PubMed]
  10. Sidlo, J.; Sidlova, H. Sudden and unexpected death due to intracranial sellar extramedullary plasmacytoma. J. Forensic Leg. Med. 2019, 61, 89–91. [Google Scholar] [CrossRef] [PubMed]
  11. Cuoco, J.A.; Rogers, C.M.; Busch, C.M.; Benko, M.J.; Apfel, L.S.; Elias, Z. Postexercise death due to hemorrhagic colloid cyst of third ventricle: Case report and literature review. World Neurosurg. 2019, 123, 351–356. [Google Scholar] [CrossRef] [PubMed]
  12. Turillazzi, E.; Bello, S.; Neri, M.; Riezzo, I.; Fineschi, V. Colloid cyst of the third ventricle, hypothalamus, and heart: A dangerous link for sudden death. Diagn. Pathol. 2012, 7, 144–148. [Google Scholar] [CrossRef]
  13. Gitto, L.; Bolino, G.; Cina, S.J. Sudden unexpected deaths due to intracranial meningioma: Presentation of six fatal cases, review of the literature and a discussion of the mechanism of death. J. Forensic Sci. 2018, 63, 947–953. [Google Scholar] [CrossRef] [PubMed]
  14. Durao, H.C.; Veiga, G.M.; Pedro, N.; Goncalves, M.M.; Pedrosa, F. Sudden death associated with melanoma brain metastates. J. Pathol. Nepal 2018, 8, 1412–1415. [Google Scholar]
  15. Glitza, I.C.; Heimberger, A.B.; Sulman, E.P.; Davies, M.A. Prognostic factors for survival in melanoma patients with brain metastates. In Brain Metastates from Primary Tumors; Hayat, M., Ed.; Academic Press: New York, NY, USA, 2016; pp. 267–292. [Google Scholar]
  16. Suranagi, V.V.; Maste, P.; Malur, P.R. Primary intracranial malignant melanoma: A rare case with review of literature. Asian J. Neurosurg. 2015, 10, 39–41. [Google Scholar] [CrossRef] [PubMed]
  17. Tosaka, M.; Tamura, M.; Oriuchi, N. Cerebrospinal fluid immunocytochemical analysis and neuroimaging in the diagnosis of primary leptomenigeal melanoma: Case report. J. Neurosurg. 2001, 94, 528–532. [Google Scholar] [CrossRef]
  18. Moher, D.; Shamseer, L.; Clarke, M.; Ghersi, D.; Liberati, A.; Petticrew, M.; Shekelle, P.; Stewart, L.A. Preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P) 2015 statement. Syst. Rev. 2015, 4, 1. [Google Scholar] [CrossRef] [PubMed]
  19. Aissaoui, A.; Mosrati, M.A.; Moussa, A.; Belhaj, M.; Bougattas, M.; Zakhama, A.; Chadly, A. Sudden death and primary leptomeningeal melanocytosis: A case report with an autopsy diagnosis. Am. J. Forensic Med. Pathol. 2015, 36, 199–201. [Google Scholar] [CrossRef] [PubMed]
  20. Ozkul, A.; Meteoglu, I.; Tataroglu, C.; Akyol, A. Primary diffuse leptomeningeal oligodendrogliomatosis causing sudden death. J. Neurooncol. 2007, 81, 75–79. [Google Scholar] [CrossRef] [PubMed]
  21. Ross, J.; Olar, A.; Fuller, C. A Pediatric Case of Diffuse Glioma Diagnosed at Autopsy. Acad. Forensic Pathol. 2017, 7, 657–666. [Google Scholar] [CrossRef] [PubMed]
  22. Havlik, D.M.; Becher, M.W.; Nolte, K.B. Sudden death due to primary diffuse leptomeningeal gliomatosis. J. Forensic Sci. 2001, 46, 392–395. [Google Scholar] [CrossRef] [PubMed]
  23. DiMaio, S.M.; DiMaio, V.J.; Kirkpatrick, J.B. Sudden, unexpected deaths due to primary intracranial neoplasms. Am. J. Forensic Med. Pathol. 1980, 1, 29–45. [Google Scholar] [CrossRef] [PubMed]
  24. Lau, G.; Sng, I. A case of sudden death from primary intracranial germinoma complicated by microvascular disease of the heart. Forensic Sci. Int. 2003, 137, 1–5. [Google Scholar] [CrossRef]
  25. Shiferaw, K.; Pizzolato, G.P.; Perret, G.; La Harpe, R. Sudden, unexpected death due to undiagnosed frontal glioblastoma in a schizophrenic patient. Forensic Sci. Int. 2006, 158, 200–203. [Google Scholar] [CrossRef] [PubMed]
  26. Matturri, L.; Ottaviani, G.; Rossi, L. Sudden and unexpected infant death due to an hemangioendothelioma located in the medulla oblongata. Adv. Clin. Pathol. 1999, 3, 29–33. [Google Scholar]
  27. Matsumoto, H.; Yamamoto, K. A case of sudden death by undiagnosed glioblastoma multiforme. Nihon Hoigaku Zasshi Jpn. J. Leg. Med. 1993, 47, 336–339. [Google Scholar]
  28. Prahlow, J.A.; Teot, L.A.; Lantz, P.E.; Stanton, C.A. Sudden death in epilepsy due to an isolated subependymal giant cell astrocytoma of the septum pellucidum. Am. J. Forensic Med. Pathol. 1995, 16, 30–37. [Google Scholar] [CrossRef]
  29. Shields, L.B.; Balko, M.G.; Hunsaker, J.C. Sudden and unexpected death from pituitary tumor apoplexy. J. Forensic Sci. 2012, 57, 262–266. [Google Scholar] [CrossRef] [PubMed]
  30. Ortiz-Reyes, R.; Dragovic, L.; Eriksson, A. Sudden unexpected death resulting from previously nonsymptomatic subependymoma. Am. J. Forensic Med. Pathol. 2002, 23, 63–67. [Google Scholar] [CrossRef] [PubMed]
  31. Nelson, J.; Frost, J.L.; Schochet, S.S., Jr. Sudden, unexpected death in a 5-year-old boy with an unusual primary intracranial neoplasm. Ganglioglioma of the medulla. Am. J. Forensic Med. Pathol. 1987, 8, 148–152. [Google Scholar] [CrossRef]
  32. Virchow, R. Pigment und diffuse melanoses der arachnoides. Virchows Arch. 1859, 16, 180–182. [Google Scholar] [CrossRef]
  33. Tang, K.; Kong, X.; Mao, G.; Quin, M.; Znov, H.; Zhou, L.; Nie, Q.; Xu, Y.; Du, S. Primary cerebral malignant melanoma. A case report with literature review. Medicine 2017, 96, e5805. [Google Scholar] [CrossRef]
  34. Liubinas, S.V.; Maartens, N.; Drummond, K.J. Primary melanocytic neoplasm of the central nervous system. J. Clin. Neurosci. 2010, 17, 1227–1232. [Google Scholar] [CrossRef]
  35. Hayward, R.D. Malignant melanoma and cerebral nervous system. A guide for classification based on the clinical findings. J. Neurol. Neurosurg. Psychiatry 1976, 39, 526–530. [Google Scholar] [CrossRef] [PubMed]
  36. Gempt, J.; Buchmann, N.; Grams, A.E. Black brain: Transformation of a melanocytoma with diffuse melanocytosis into a primary cerebral melanoma. J. Neurooncol. 2011, 102, 323–328. [Google Scholar] [CrossRef] [PubMed]
  37. Bydon, A.; Guttierez, J.A.; Mahmood, A. Meningeal melanocytoma: An aggressive course for a benign tumor. J. Neurooncol. 2003, 64, 259–263. [Google Scholar] [CrossRef] [PubMed]
  38. Rades, D.; Schild, S.E. Dose responde relationship for fractionated irradiation in the treatment of spinal meningeal melanocytomas: A review of the literature. J. Neurooncol. 2006, 77, 311–314. [Google Scholar] [CrossRef] [PubMed]
  39. Troya-Castilla, M.; Rocha-Romero, S.; Crochon-Gonzales, Y.; Marquez-Rivas, F.J. Primary cerebral malignant melanoma in insular region with extracranial metastasis: Case report and review literature. World J. Surg. Oncol. 2016, 14, 235–242. [Google Scholar] [CrossRef] [PubMed]
  40. Brachmann, D.E.; Doherty, J.K. CPA melanoma: Diagnosis and management. Otol. Neurotol. 2007, 28, 529–537. [Google Scholar] [CrossRef] [PubMed]
  41. Bhandari, L.; Alapatt, J.; Govindan-Sreekumar, T. Primary cerebellopontine angle melanoma: A case report and review. Turk. Neurosurg. 2012, 22, 469–474. [Google Scholar] [CrossRef]
  42. Arantes, M.; Castro, A.F.; Romao, H.; Meireles, P.; Garcia, R.; Honavar, M.; Vaz Ar Resende, M. Primary pineal malignant melanoma: Case report and literature review. Clin. Neurosurg. 2011, 113, 59–64. [Google Scholar] [CrossRef] [PubMed]
  43. Greco Castro, S.; Soffietti, R.; Bradac, G.B.; Boldorini, R. Primitive cerebral melanoma: Case report and review of the literature. Surg. Neurol. 2001, 55, 163–168. [Google Scholar] [CrossRef]
  44. Quillo-Olvera, J.; Uribe-Olalde, J.S.; Alcantara-Gomez, L.A.; Rejon-Perez, J.D.; Palomera-Gomez, H.G. Primary malignant melanoma of the central nervous system: A diagnostic challenge. Cir. Cir. 2015, 83, 129–134. [Google Scholar] [CrossRef] [PubMed]
  45. Wadasadawala, T.; Trivedi, S.; Gupta, T.; Epari, S.; Jalari, R. The diagnostic dilemma of primary central nervous system melanoma. J. Clin. Neurosci. 2010, 17, 1014–1017. [Google Scholar] [CrossRef] [PubMed]
  46. Lee, P.H.; Wang, L.C.; Lee, E.J. Primary intracranial melanoma. J. Cancer Res. Pract. 2017, 4, 23–26. [Google Scholar] [CrossRef]
  47. Berzero, G.; Diamanti, L.; Di Stefano, A.L.; Bini, P.; Franciotta, D.; Imarisio, I.; Pedrazzoli, P.; Magrassi, L.; Morbini, P.; Farina, L.M.; et al. Meningeal Melanomatosis: A challenge for timely diagnosis. BioMed Res. Int. 2015, 2015, 6. [Google Scholar] [CrossRef]
  48. Gleissner, B.; Chamberlain, M.C. Neoplastic meningitis. Lancet Neurol. 2006, 5, 443–452. [Google Scholar] [CrossRef]
  49. Sarnast, A.H.; Mujtaba, B.; Bhat, A.R.; Kirmani, A.R.; Tanki, H.N. A unique case of primary intracranial melanoma. Asian J. Neurosurg. 2018, 13, 168–171. [Google Scholar] [CrossRef] [PubMed]
  50. Davies, M.A.; Liu, P.; Mcintyre, S.; Kim, K.B.; Papadopoulos, N.; Hwu, W.J.; Bedikian, A. Prognostic factors for survival in melanoma patients with brain metastates. Cancer 2011, 117, 1687–1696. [Google Scholar] [CrossRef] [PubMed]
  51. Raizer, J.J.; Hwu, W.J.; Panageas, K.S. Brain and leptomenigeal metastates from cutaneous melanoma: Survival outcomes based on clinical features. Neurol. Oncol. 2008, 10, 199–207. [Google Scholar] [CrossRef]
  52. Cohen, J.V.; Tawbi, H.; Margolin, K.A.; Amravadi, R.; Bosenberg, M.; Brastianos, P.K.; Chiang, V.L.; De Groot, J.; Glitza, I.C.; Herlin, M. Melanoma central nervous system metastates: Current approaches, challenges, and opportunities. Pigment Cell Melanoma Res. 2016, 29, 627–642. [Google Scholar] [CrossRef] [PubMed]
  53. Cohen, J.V.; Alomari, A.K.; Vortmeyer, A.O.; Jilaveanu, L.B.; Gold-Berg, S.B.; Mahajan, A.; Chiang, V.L.; Kluger, H.M. Melanoma brain metastasis pseudoprogression after pembrolizumab treatment. Cancer Immunol. Res. 2016, 4, 179–182. [Google Scholar] [CrossRef] [PubMed]
  54. Braeuer, R.R.; Watson, I.R.; Wu, C.S.; Mobley, A.K.; Kamiya, T.; Shoshan, E.; Bar-Eli, M. Why is melanoma so metastatic? Pigment Cell Melanoma Res. 2013, 27, 19–36. [Google Scholar] [CrossRef]
  55. Rodriguez y Baena, R.; Gaetani, P.; Danova, M. Primary solitary intracranial melanoma: Case report and review of the literature. Surg. Neurol. 1992, 38, 26–37. [Google Scholar] [CrossRef]
  56. Balakrishnan, R.; Porag, R.; Asif, D.S. Primary intracranial melanoma with early leptomeningeal spread: A case report and treatment options available. Case Rep. Oncol. Med. 2015, 29, 3802. [Google Scholar] [CrossRef]
  57. Garbacz, T.; Osuchowski, M.; Bartosik-Psujek, H. Primary diffuse meningeal melanomatosis—A rare form of meningeal melanoma: Case report. BMC Neurol. 2019, 19, 271–275. [Google Scholar] [CrossRef] [PubMed]
  58. Morais, S.; Cabral, A.; Santos, G.; Madeira, N. Melanoma brain metastates presenting as delirium: A case report. Arch Clin. Psychiatry 2017, 44, 53–54. [Google Scholar]
  59. Lin, B.; Yang, H.; Qu, L.; Li, Y.; Yu, J. Primary meningeal melanocytoma of the anterior cranial fossa: A case report and review of the literature. World J. Surg. Oncol. 2012, 10, 135. [Google Scholar] [CrossRef] [PubMed]
  60. Samuels, M.A. The brain-heart connection. Circulation 2007, 116, 77–84. [Google Scholar] [CrossRef] [PubMed]
  61. Goldberg, E.M.; Schwartz, E.S.; Younkin, D.; Myers, S.R. Atypical Syncope in a child due to a colloid of the third ventricle. Pediatr. Neurol. 2011, 45, 331–334. [Google Scholar] [CrossRef] [PubMed]
  62. Nikolaeov, S.I.; Rimoldi, D.; Iseli, C. Exome sequencing identifies recurrent somatic MAP2K1 and MAP2K2 mutations in melanoma. Nat. Genet. 2012, 44, 133–139. [Google Scholar] [CrossRef]
  63. Stark, M.S.; Woods, S.L.; Gartside, M.G. Frequent somatic mutations in MAP3K5 and MAP3K9 in metastatic melanoma identified by exome sequencing. Nat. Genet. 2012, 44, 165–169. [Google Scholar] [CrossRef] [PubMed]
  64. Kusters-Vandevelde, H.V.N.; Kusters, B.; Van Engen-Van Grusven, A.C.H.; Groenen, P.J.T.A.; Wesseling, P.; Blokx, W.A.M. Primary melanocytic tumors of the central nervous system: A review with focus on molecular aspects. Brain Pathol. 2015, 25, 209–226. [Google Scholar] [CrossRef] [PubMed]
  65. Pan, Z.; Yang, G.; Wang, Y.; Yuan, T.; Gao, Y.; Dong, L. Leptomeningeal metastases from a primary central nervous system melanoma: A case report and literature review. World J. Surg. Oncol. 2014, 12, 265–272. [Google Scholar] [CrossRef]
  66. Ma, Y.; Gui, Q.; Lang, S. Intracranial malignant melanoma: A report of 7 cases. Oncol. Lett. 2015, 10, 2171–2175. [Google Scholar] [CrossRef] [PubMed]
  67. Isiklar, I.; Leeds, N.E.; Fuller, G.N.; Kumar, A.J. Intracranial metastatic melanoma: Correlation between MR imaging characteristics and melanin content. Am. J. Roentgenol. 1995, 165, 1503–1512. [Google Scholar] [CrossRef] [PubMed]
  68. Chen, C.J.; Hsu, Y.I.; Ho, Y.S. Intracranial meningeal melanocytoma. CT and MRI. Neuroradiology 1997, 39, 811–814. [Google Scholar] [CrossRef] [PubMed]
  69. Lee, H.J.; Ahn, B.C.; Hwang, S.W.; Cho, S.K.; Kim, H.W.; Lee, S.W.; Hwang, J.H.; Lee, J. F-18 fluorodeoxyglucose PET/CT and post hoc PET/MRI in a case of primary meningeal melanomatosis. Korean J. Radiol. 2013, 14, 343–349. [Google Scholar] [CrossRef] [PubMed]
  70. Young, G.J.; Bi, W.L.; Wu, W.W.; Johanns, T.M.; Dung, G.P.; Dun, I.F. Management of intracranial melanomas in the era of precision medicine. Oncotarget 2017, 8, 89326–89347. [Google Scholar] [CrossRef][Green Version]
  71. Kircher, D.A.; Silvis, M.R.; Cho, J.H.; Holmen, S.L. Melanoma brain metastasis: Mechanism, models and medicine. Int. J. Mol. Sci. 2016, 17, 1468. [Google Scholar] [CrossRef]
  72. Abate-Daga, D.; Ramello, M.C.; Smalley, I.; Forsyth, P.A.; Smalley, K.S.M. The biology and therapeutic management of melanoma brain metastases. Biochem. Pharm. 2018, 153, 35–45. [Google Scholar] [CrossRef]
  73. Basnet, A.; Saad, N.; Benjamin, S. A case of vanishing brain metastasis in a melanoma patient on nivolumab. Anticancer Res. 2016, 36, 4795–4798. [Google Scholar] [CrossRef] [PubMed]
  74. Puyana, C.; Denyer, S.; Burch, T.; Bhimani, A.D.; McGuire, L.S.; Patel, A.S.; Mehta, A.I. Primary Malignant Melanoma of the Brain: A Population-Based Study. World Neurosurg. 2019, 130, 1091–1097. [Google Scholar] [CrossRef] [PubMed]
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