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A New Therapeutic Strategy for Recurrent Ovarian Cancer―Bevacizumab beyond Progressive Disease
Open AccessArticle

Clinical Determinants Affecting Indications for Surgery and Chemotherapy in Recurrent Ovarian Granulosa Cell Tumor

1
Department of Obstetrics and Gynecology, Faculty of Medicine, Kindai University, Osaka 589-8511, Japan
2
Department of Obstetrics and Gynecology, Kyoto Graduate School of Medicine, Kyoto University, Kyoto 606-8507, Japan
*
Author to whom correspondence should be addressed.
Healthcare 2019, 7(4), 145; https://doi.org/10.3390/healthcare7040145
Received: 22 October 2019 / Revised: 11 November 2019 / Accepted: 13 November 2019 / Published: 14 November 2019
(This article belongs to the Special Issue Diagnosis and Treatment for Gynecologic Cancers)
Background: Because reports on the management of recurrent granulosa cell tumor have been sparse, a consensus as to which patients should undergo surgical resection and which patients should be considered for chemotherapy has not been established. Methods: A total of 21 tumor recurrences in eight patients with granulosa cell tumor were reviewed. Results: Surgery was performed as the main treatment for 13 recurrences, while chemotherapy was chosen as the main treatment for eight recurrences. Complete tumor resection could be accomplished in 13 of 16 surgeries (81.3%), which include all the ten recurrences without involvement of liver or diaphragm and without ascites. The number of recurrent masses was significantly higher in the early recurrence group (progression free survival < 2 years) than in the late recurrence (progression free survival > 2 years). All cases with a solitary recurrent tumor at an extra-peritoneal site presented a significantly longer progression free survival. Conclusions: For patients with recurrent granulosa cell tumor, surgery may provide the best disease control. In cases with complete resection, the number of recurrent masses was the predictive factor for the next recurrence, and adjuvant chemotherapy might be considered in such cases. View Full-Text
Keywords: recurrent granulose cell tumor; predictive factor; treatment strategy; surgery; adjuvant chemotherapy recurrent granulose cell tumor; predictive factor; treatment strategy; surgery; adjuvant chemotherapy
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MDPI and ACS Style

Nakai, H.; Koike, E.; Murakami, K.; Takaya, H.; Kotani, Y.; Nakai, R.; Suzuki, A.; Aoki, M.; Matsumura, N.; Mandai, M. Clinical Determinants Affecting Indications for Surgery and Chemotherapy in Recurrent Ovarian Granulosa Cell Tumor. Healthcare 2019, 7, 145. https://doi.org/10.3390/healthcare7040145

AMA Style

Nakai H, Koike E, Murakami K, Takaya H, Kotani Y, Nakai R, Suzuki A, Aoki M, Matsumura N, Mandai M. Clinical Determinants Affecting Indications for Surgery and Chemotherapy in Recurrent Ovarian Granulosa Cell Tumor. Healthcare. 2019; 7(4):145. https://doi.org/10.3390/healthcare7040145

Chicago/Turabian Style

Nakai, Hidekatsu; Koike, Eiji; Murakami, Kosuke; Takaya, Hisamitsu; Kotani, Yasushi; Nakai, Rika; Suzuki, Ayako; Aoki, Masato; Matsumura, Noriomi; Mandai, Masaki. 2019. "Clinical Determinants Affecting Indications for Surgery and Chemotherapy in Recurrent Ovarian Granulosa Cell Tumor" Healthcare 7, no. 4: 145. https://doi.org/10.3390/healthcare7040145

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