The Effectiveness of a Single Dry Needling Session on Gait and Quality of Life in Multiple Sclerosis: A Double-Blind Randomized Sham-Controlled Pilot Trial
Abstract
:1. Introduction
2. Materials and Methods
2.1. Study Design
2.2. Participants
2.3. Randomization and Blinding
2.4. Interventions
2.5. Outcomes
2.6. Primary Outcome
2.7. Secondary Outcomes
2.8. Data Analysis
3. Results
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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IG (Active Dry Needling, n = 9) | CG (Sham Dry Needling, n = 9) | p-Value | |
---|---|---|---|
Age (years) | 48.00 ± 6.00 | 46.67 ± 9.38 | 0.920 |
Sex (% female) | 5 (55.56%) | 6 (66.67%) | - |
Walking aid | 5 (55.56%) | 4 (44.44%) | - |
BMI (kg/m2) | 23.12 ± 3.49 | 25.59 ± 4.37 | 0.310 |
Disease duration (years) | 12.33 ± 7.31 | 9.89 ± 6.77 | 0.400 |
Type of MS | RRMS = 55% PPMS = 45% | RRMS = 55% PPMS = 45% | - |
T25FW | 11.35 ± 10.84 | 7.38 ± 2.11 | 0.546 |
MSWS-12 | 39.33 ± 10.90 | 30.56 ± 11.33 | 0.077 |
TUG | 12.08 ± 5.25 | 10.27 ± 2.49 | 0.489 |
EDSS total | 4.94 ± 1.21 | 3.83 ± 1.20 | 0.400 |
EDSS pyramidal | 3.33 ± 1.23 | 2.89 ± 0.93 | 0.489 |
MSQol-54 Physical | 55.27 ± 19.70 | 59.41 ± 16.72 | 0.190 |
MSQol-54 Mental | 44.24 ± 19.48 | 58.29 ± 18.60 | 0.161 |
AQL | 6.22 ± 2.39 | 5.89 ± 1.45 | 0.796 |
Variable | Group | Descriptive Data | Within-Group Differences | Between-Group Differences | ||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Baseline | Post | 1 Week | 4 Weeks | Global a | Post b | 1 Week b | 4 Weeks b | Post c | 1 Week c | 4 Weeks c | ||
T25FW | IG SG | 11.35 ± 10.84 7.38 ± 2.11 | 9.81 ± 8.18 7.01 ± 1.84 | 11.69 ± 12.64 7.18 ± 1.83 | 10.83 ± 9.97 6.95 ± 1.92 | p = 0.042 * p = 0.082 | −1.54 ± 2.66 (p = 0.008) * −0.37 ± 0.13 (p = 0.082) | 0.34 ± 1.80 (p = 0.515) −0.20 ± 0.10 | −0.52 ± 0.87 (p = 0.260) −0.43 ± 0.19 | 2.8 ± 6.34 (p = 0.077) | 4.51 ± 10.81 (p = 0.489) | 3.88 ± 8.14 (p = 0.863) |
MSWS-12 | IG SG | 39.33 ± 10.90 30.56 ± 11.33 | - - | 35.89 ± 11.26 31.11 ± 13.93 | 36.33 ± 9.98 32.22 ± 15.01 | p = 0.002 * p = 0.962 | - - | −3.44 ± 0.36 (p = 0.017) * 0.55 ± 0.60 (p = 0.962) | −3.00 ± 0.93 (p = 0.011) * 1.66 ± 3.68 | - | 4.78 ± −2.67 (p = 0.063) | 4 ± −5.03 (p = 0.063) |
TUG | IG SG | 12.08 ± 5.25 10.27 ± 2.49 | 11.06 ± 5.28 9.41 ± 2.08 | 11.29 ± 6.91 10.03 ± 2.93 | 13.26 ± 10.35 9.82 ± 2.91 | p = 0.015 * p = 0.091 | −1.02 ± 0.03 (p = 0.008) * −0.86 ± 0.10 (p = 0.091) | −0.79 ± 1.65 (p = 0.110) −0.24 ± 0.44 | 1.18 ± 5.10 (p = 0.678) −0.45 ± 0.41 | 1.65 ± 3.21 (p = 0.666) | 1.26 ± 3.97 (p = 0.113) | 3.44 ± 7.44 (p = 0.931) |
EDSS Total | IG SG | 4.94 ± 1.21 3.83 ± 1.20 | - - | - - | 4.94 ± 1.21 3.83 ± 1.20 | p = 1.000 p = 1.000 | - - | - - | No change No change | - | - | 1.11 ± 0.01 (p = 1.000) |
EDSS Pyramidal | IG SG | 3.33 ± 1.23 2.89 ± 0.93 | - - | - - | 3.44 ± 1.13 2.89 ± 0.93 | p = 0.317 p = 1.000 | - - | - - | 0.11 ± 0.10 No change | - | - | 0.55 ± 0.20 (p = 0.730) |
MSQol-54 Physical | IG SG | 55.27 ± 19.71 59.41 ± 16.72 | - - | - - | 61.50 ± 23.43 59.00 ± 18.67 | p = 1.000 p = 1.000 | - - | - - | 6.23 ± 3.73 (p = 0.014 *) −0.41 ± 1.95 (p = 0.096) | - | - | 6.23 ± 3.95 (p = 0.014) * |
MSQol-54 Mental | IG SG | 44.24 ± 19.48 58.29 ± 18.60 | - - | - - | 46.76 ± 19.19 55.82 ± 19.56 | p = 0.096 p = 0.096 | - - | - - | 2.52 ± 0.12 (p = 0.096) −2.47 ± 0.96 (p = 0.096) | - | - | 2.52 ± −0.29 (p = 0.297) |
AQL | IG SG | 6.22 ± 2.39 5.89 ± 1.45 | - - | 6.02 ± 1.81 6.11 ± 1.27 | 6.56 ± 2.12 6.22 ± 1.48 | p = 0.001 * p = 0.001 * | - - | −0.18 ± −0.58 (p =0.441) 0.22 ± −0.18 (p =0.953) | 0.54 ± 0.18 (p =0.008 *) 0.33 ± 0.03 (p =0.008 *) | - - | 0.09 ± −0.54 (p = 0.863) | −0.34 ± −0.64 (p = 1.000) |
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Javier-Ormazábal, A.; González-Platas, M.; Jiménez-Sosa, A.; Herrero, P.; Lapuente-Hernández, D. The Effectiveness of a Single Dry Needling Session on Gait and Quality of Life in Multiple Sclerosis: A Double-Blind Randomized Sham-Controlled Pilot Trial. Healthcare 2024, 12, 10. https://doi.org/10.3390/healthcare12010010
Javier-Ormazábal A, González-Platas M, Jiménez-Sosa A, Herrero P, Lapuente-Hernández D. The Effectiveness of a Single Dry Needling Session on Gait and Quality of Life in Multiple Sclerosis: A Double-Blind Randomized Sham-Controlled Pilot Trial. Healthcare. 2024; 12(1):10. https://doi.org/10.3390/healthcare12010010
Chicago/Turabian StyleJavier-Ormazábal, Alberto, Montserrat González-Platas, Alejandro Jiménez-Sosa, Pablo Herrero, and Diego Lapuente-Hernández. 2024. "The Effectiveness of a Single Dry Needling Session on Gait and Quality of Life in Multiple Sclerosis: A Double-Blind Randomized Sham-Controlled Pilot Trial" Healthcare 12, no. 1: 10. https://doi.org/10.3390/healthcare12010010