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Exploring the Psoriatic Arthritis Proteome in Search of Novel Biomarkers

by Shalini M. Mahendran 1,2 and Vinod Chandran 1,3,4,5,*
Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON M5S 1A1, Canada
Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, ON M5T 3L9, Canada
Centre for Prognosis Studies in Rheumatic Diseases, Krembil Research Institute, Toronto Western Hospital, University Health Network, Toronto, ON M5T 1M8, Canada
Division of Rheumatology, Department of Medicine, University of Toronto, Toronto, ON M5T 1A1, Canada
Institute of Medical Science, University of Toronto, Toronto, ON M5T 1A1, Canada
Author to whom correspondence should be addressed.
Proteomes 2018, 6(1), 5;
Received: 18 December 2017 / Revised: 16 January 2018 / Accepted: 21 January 2018 / Published: 24 January 2018
(This article belongs to the Special Issue Proteomic Biomarkers in Human Diseases)
Psoriatic arthritis (PsA) is an inflammatory arthritis which develops in up to one-third of patients suffering from the cutaneous disorder, psoriasis. The complex and heterogeneous nature of PsA renders it difficult to diagnose, leading to poor outcomes and, therefore, warrants an examination into soluble biomarkers, which may facilitate early detection of the disease. Protein biomarkers are a dynamic resource of pathophysiological information able to provide an immediate reflection of pathological changes caused by disease. Investigations of the serum and synovial fluid of PsA patients has provided new insights into the molecular basis of this disease and led to the identification of sensitive diagnostic and prognostic biomarkers. The collection of novel PsA biomarkers identified through proteomic studies has been reviewed below. View Full-Text
Keywords: proteomics; biomarkers; psoriatic arthritis; serum; synovial fluid proteomics; biomarkers; psoriatic arthritis; serum; synovial fluid
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Mahendran, S.M.; Chandran, V. Exploring the Psoriatic Arthritis Proteome in Search of Novel Biomarkers. Proteomes 2018, 6, 5.

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