Next Article in Journal
The Perspectives of Patients and Health Professionals Regarding the Tuberculosis Control Programme in Recife, Brazil: A Contribution to Evaluation
Next Article in Special Issue
Allergic Reactions and Cross-Reactivity Potential with Beta-Lactamase Inhibitors
Previous Article in Journal
The Discharge Companion Program: An Interprofessional Collaboration in Transitional Care Model Delivery
Article Menu
Issue 2 (June) cover image

Export Article

Open AccessReview

Strategies for Clarifying Penicillin Allergies When Skin Testing Is Not an Option

McWhorter School of Pharmacy, Samford University, Birmingham, AL 35209, USA
Antimicrobial Stewardship Program, University of Mississippi Medical Center, Jackson, MS 39216, USA
Pharmacy Practice, Roseman University of Health Sciences College of Pharmacy, Henderson, NV 89014, USA
School of Pharmacy, University of Mississippi, Jackson, MS 39216, USA
Author to whom correspondence should be addressed.
Pharmacy 2019, 7(2), 69;
Received: 9 May 2019 / Revised: 10 June 2019 / Accepted: 17 June 2019 / Published: 19 June 2019
(This article belongs to the Special Issue Antibiotic Allergies)
PDF [235 KB, uploaded 19 June 2019]


Patients with reported penicillin allergies have been proven to experience negative health consequences, such as increased cost, suboptimal antimicrobial therapy, and adverse reactions. Though skin testing has been proposed as a method to clarify penicillin allergies, many institutions may lack the resources to perform skin testing on a wide scale. This literature review describes the current literature surrounding the use of penicillin allergy interviews when skin testing is not an option. Specifically, the review highlights the steps in carrying out a successful antibiotic allergy patient interview, summarizes the clinical evidence surrounding antibiotic allergy clarifications, and addresses key advantages and disadvantages of clarifying antibiotic allergies without the availability of skin testing. View Full-Text
Keywords: allergy; antibiotic; penicillin; beta-lactam; skin testing allergy; antibiotic; penicillin; beta-lactam; skin testing
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

Share & Cite This Article

MDPI and ACS Style

W. Covington, E.; B. Wingler, M.J.; Jayakumar, R.A.; White, C.W. Strategies for Clarifying Penicillin Allergies When Skin Testing Is Not an Option. Pharmacy 2019, 7, 69.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Pharmacy EISSN 2226-4787 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top