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Strategies for Clarifying Penicillin Allergies When Skin Testing Is Not an Option

1
McWhorter School of Pharmacy, Samford University, Birmingham, AL 35209, USA
2
Antimicrobial Stewardship Program, University of Mississippi Medical Center, Jackson, MS 39216, USA
3
Pharmacy Practice, Roseman University of Health Sciences College of Pharmacy, Henderson, NV 89014, USA
4
School of Pharmacy, University of Mississippi, Jackson, MS 39216, USA
*
Author to whom correspondence should be addressed.
Pharmacy 2019, 7(2), 69; https://doi.org/10.3390/pharmacy7020069
Received: 9 May 2019 / Revised: 10 June 2019 / Accepted: 17 June 2019 / Published: 19 June 2019
(This article belongs to the Special Issue Antibiotic Allergies)
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PDF [235 KB, uploaded 19 June 2019]

Abstract

Patients with reported penicillin allergies have been proven to experience negative health consequences, such as increased cost, suboptimal antimicrobial therapy, and adverse reactions. Though skin testing has been proposed as a method to clarify penicillin allergies, many institutions may lack the resources to perform skin testing on a wide scale. This literature review describes the current literature surrounding the use of penicillin allergy interviews when skin testing is not an option. Specifically, the review highlights the steps in carrying out a successful antibiotic allergy patient interview, summarizes the clinical evidence surrounding antibiotic allergy clarifications, and addresses key advantages and disadvantages of clarifying antibiotic allergies without the availability of skin testing. View Full-Text
Keywords: allergy; antibiotic; penicillin; beta-lactam; skin testing allergy; antibiotic; penicillin; beta-lactam; skin testing
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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W. Covington, E.; B. Wingler, M.J.; Jayakumar, R.A.; White, C.W. Strategies for Clarifying Penicillin Allergies When Skin Testing Is Not an Option. Pharmacy 2019, 7, 69.

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