Antipsychotic Use: Cross-Sectional Opinion Survey of Psychiatrists in India and United Kingdom
Abstract
:1. Introduction
2. Methods
3. Results
3.1. Prescribing Preferences
3.2. Antipsychotic Agent Switching or Combining
3.3. Factors Leading to Patient Relapse
3.4. Use of Long-Acting Injectable Antipsychotic Formulations
3.5. Side Effects
3.6. Use of Scales for Assessment/Monitoring
4. Discussion
4.1. Most Prescribed Medications
4.2. Reported Side Effects
4.3. Reasons for Switching, Adding or Stopping APDs
4.4. Reasons for Switching to LAIs
4.5. Possible Causes for Relapse
5. Limitations
6. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Oral First-Generation (Typical) | Oral Second-Generation (Atypical) |
---|---|
Benperidol Chlorpromazine Flupentixol Haloperidol Levomepromazine Pericyazine Perphenazine Pimozide Prochlorperazine Promazine Sulpiride Trifluoperazine Zuclopenthixol | Amisulpride Aripiprazole Cariprazine Clozapine Olanzapine Paliperidone Quetiapine Risperidone |
Side Effect | Nonadherence to APDs (n = 1406) | Switching to Another APD (n = 1473) | Cease the Use of APDs (n = 1091) |
---|---|---|---|
Agitation | 46, 3.3% | 52, 3.6% | 36, 3.3% |
Amenorrhea | 51, 3.6% | 52, 3.6% | 29,2.7% |
Confusion | 15, 1.1% | 31, 2.1% | 37, 3.4% |
Dizziness | 64, 4.6% | 39, 2.7% | 15, 1.4% |
Drowsiness | 146, 10.4% | 96, 6.6% | 50, 4.6% |
Dry mouth | 50, 3.6% | 20, 1.4% | 8, 0.7% |
Erectile dysfunction | 122, 8.7% | 83, 5.7% | 56, 5.1% |
Fatigue | 66, 4.7% | 35, 2.4% | 24, 2.2% |
Galactorrhoea | 52, 3.7% | 67, 4.6% | 46, 4.2% |
Gynaecomastia | 35, 2.5% | 41, 2.8% | 39, 3.6% |
Hyperglycaemia | 30, 2.1% | 59, 4.0% | 42, 3.8% |
Hyperprolactinaemia | 57, 4.1% | 103, 7.0% | 58, 5.3% |
Hypotension | 18, 1.3% | 28, 1.9% | 27, 2.5% |
Insomnia | 16, 1.1% | 14, 1.0% | 13, 1.2% |
Life-threatening | 0, 0% | 78, 5.3% | 115, 10.5% |
Movement disorders | 122, 8.7% | 112, 7.7% | 76, 7.0% |
Muscle rigidity | 79, 5.6% | 78, 5.3% | 45, 4.1% |
Parkinsonism | 90, 6.4% | 90, 6.1% | 48, 4.4% |
Postural hypotension | 35, 2.5% | 30, 2.0% | 28, 2.6% |
QT interval prolongation | 28, 2.0% | 84, 5.7% | 102, 9.3% |
Seizure | 11, 0.8% | 50, 3.4% | 67, 6.1% |
Tremor | 95, 6.8% | 59, 4.0% | 30, 2.7% |
Urinary retention | 19, 1.4% | 36, 2.5% | 34, 3.1% |
Vomiting | 7, 0.5% | 8, 0.5% | 6, 0.5% |
Weight gain | 152, 10.8% | 119, 8.1% | 60, 5.5% |
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Qadir, Z.S.; Kar, N.; Ball, P.A.; Morrissey, H. Antipsychotic Use: Cross-Sectional Opinion Survey of Psychiatrists in India and United Kingdom. Pharmacy 2023, 11, 162. https://doi.org/10.3390/pharmacy11050162
Qadir ZS, Kar N, Ball PA, Morrissey H. Antipsychotic Use: Cross-Sectional Opinion Survey of Psychiatrists in India and United Kingdom. Pharmacy. 2023; 11(5):162. https://doi.org/10.3390/pharmacy11050162
Chicago/Turabian StyleQadir, Zina Sherzad, Nilamadhab Kar, Patrick Anthony Ball, and Hana Morrissey. 2023. "Antipsychotic Use: Cross-Sectional Opinion Survey of Psychiatrists in India and United Kingdom" Pharmacy 11, no. 5: 162. https://doi.org/10.3390/pharmacy11050162
APA StyleQadir, Z. S., Kar, N., Ball, P. A., & Morrissey, H. (2023). Antipsychotic Use: Cross-Sectional Opinion Survey of Psychiatrists in India and United Kingdom. Pharmacy, 11(5), 162. https://doi.org/10.3390/pharmacy11050162