Next Article in Journal
Imaging Neuronal Activity in the Optic Tectum of Late Stage Larval Zebrafish
Next Article in Special Issue
Wingless/Wnt Signaling in Intestinal Development, Homeostasis, Regeneration and Tumorigenesis: A Drosophila Perspective
Previous Article in Journal
Dynamic Tissue Rearrangements during Vertebrate Eye Morphogenesis: Insights from Fish Models
Previous Article in Special Issue
The Biology of SUMO-Targeted Ubiquitin Ligases in Drosophila Development, Immunity, and Cancer
Article Menu

Export Article

Open AccessReview
J. Dev. Biol. 2018, 6(1), 5; https://doi.org/10.3390/jdb6010005

Flying the RNA Nest: Drosophila Reveals Novel Insights into the Transcriptome Dynamics of Early Development

1
Institut de Recherches Cliniques de Montréal (IRCM), Montréal, QC H2W 1R7, Canada
2
Département de Biochimie, Université de Montréal, Montréal, QC H3T 1J4, Canada
3
Division of Experimental Medicine, McGill University, Montréal, QC H3A 0G4, Canada
4
IRCM, RNA Biology Laboratory, 110 Avenue des Pins, Ouest, Montréal, QC H2W 1R7, Canada
*
Author to whom correspondence should be addressed.
Received: 15 February 2018 / Revised: 1 March 2018 / Accepted: 5 March 2018 / Published: 7 March 2018
(This article belongs to the Special Issue Drosophila - A Model System for Developmental Biology)
Full-Text   |   PDF [3036 KB, uploaded 7 March 2018]   |  

Abstract

Early development is punctuated by a series of pervasive and fast paced transitions. These events reshape a differentiated oocyte into a totipotent embryo and allow it to gradually mount a genetic program of its own, thereby framing a new organism. Specifically, developmental transitions that ensure the maternal to embryonic control of developmental events entail a deep remodeling of transcriptional and transcriptomic landscapes. Drosophila provides an elegant and genetically tractable system to investigate these conserved changes at a dazzling developmental pace. Here, we review recent studies applying emerging technologies such as ribosome profiling, in situ Hi-C chromatin probing and live embryo RNA imaging to investigate the transcriptional dynamics at play during Drosophila embryogenesis. In light of this new literature, we revisit the main models of zygotic genome activation (ZGA). We also review the contributions played by zygotic transcription in shaping embryogenesis and explore emerging concepts of processes such as transcriptional bursting and transcriptional memory. View Full-Text
Keywords: embryogenesis; Drosophila; development; RNA; transcriptomics; RNA; zygotic genome activation; posttranscriptional regulation; maternal-to-zygotic transition; epigenetics embryogenesis; Drosophila; development; RNA; transcriptomics; RNA; zygotic genome activation; posttranscriptional regulation; maternal-to-zygotic transition; epigenetics
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
SciFeed

Share & Cite This Article

MDPI and ACS Style

Lefebvre, F.A.; Lécuyer, É. Flying the RNA Nest: Drosophila Reveals Novel Insights into the Transcriptome Dynamics of Early Development. J. Dev. Biol. 2018, 6, 5.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
J. Dev. Biol. EISSN 2221-3759 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top