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Influence of Monoterpenes in Biological Activities of Nectandra megapotamica (Spreng.) Mez Essential Oils

1
Pharmaceutical Sciences Graduate Program, Federal University of Rio Grande do Sul, Av. Ipiranga, 2752, 90610 000 Porto Alegre, Brazil
2
Departament of Inorganic Chemistry, Chemistry Institute, Federal University of Rio Grande do Sul, Av. Bento Gonçalves, 9500, 91501 970 Porto Alegre, Brazil
*
Author to whom correspondence should be addressed.
Biomolecules 2019, 9(3), 112; https://doi.org/10.3390/biom9030112
Received: 5 February 2019 / Revised: 9 March 2019 / Accepted: 13 March 2019 / Published: 21 March 2019
(This article belongs to the Special Issue Evaluation and formulation of Bioactive Terpenes)
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Abstract

Investigating the influence of seasonal variations on biological activities is important for pharmacological studies and metabolic engineering. Therefore, this study was conducted to determine the variation of the chemical composition of essential oils obtained from Nectandra megapotamica leaves, collected at different stages of plant development, as well as its influence on the biological activities. A total of 38 compounds were identified that accounted for 97–99.2% of the chemical composition of the oils. Major differences were observed in the monoterpenic fraction, representing 5.1% of the compounds identified in the productive rest phase to 37.1% in the blooming phase. Bicyclogermacrene and germacrene D were the predominant compounds identified in the oil of all collections. Furthermore, limonene, β-pinene, and spathulenol were identified predominantly in the samples of blooming and fruiting phases. The oils exhibited significant antichemotactic activity and different effects in scavenging the radical 2,2-diphenyl-1-picrylhydrazyl. Variations were also observed in the antifungal activity, with the minimum inhibitory concentrations ranging from 125 to 500 μg/mL. These results demonstrate the influence of monoterpenes, primarily limonene, α-pinene, and β-pinene, on the bioactivities of the oil. Studies investigating the variations in the chemical composition of essential oil may offer a strategy to produce a compound or a group of compounds of interest to industries with a specific pharmacological focus. View Full-Text
Keywords: biological activities; essential oil; monoterpenes; Nectandra megapotamica; principal component analysis; seasonal variation biological activities; essential oil; monoterpenes; Nectandra megapotamica; principal component analysis; seasonal variation
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MDPI and ACS Style

Danielli, L.J.; de Souza, T.J.; Maciel, A.J.; Ferrão, M.F.; Fuentefria, A.M.; Apel, M.A. Influence of Monoterpenes in Biological Activities of Nectandra megapotamica (Spreng.) Mez Essential Oils. Biomolecules 2019, 9, 112.

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