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Biomolecules 2018, 8(4), 117; https://doi.org/10.3390/biom8040117

Association of Adiponectin and rs1501299 of the ADIPOQ Gene with Prediabetes in Jordan

1
Department of Physiology and Biochemistry, School of Medicine, Jordan University of Science and Technology, Irbid 22110, Jordan
2
Department of Family Medicine and Public Health, School of Medicine, Jordan University of Science and Technology, Irbid 22110, Jordan
3
Department of Rehabilitation Sciences, School of Applied Medical Sciences, Jordan University of Science and Technology, Irbid 22110, Jordan
*
Author to whom correspondence should be addressed.
Received: 4 September 2018 / Revised: 7 October 2018 / Accepted: 8 October 2018 / Published: 22 October 2018
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Abstract

Type 2 diabetes mellitus (T2DM) is a worldwide health problem caused by resistance to insulin action. This chronic debilitating diseaseis preceded by a stage, known as prediabetes, in which a healthy lifestyle can delay the disease. The discovery of biochemical changes in prediabetes is important to identify individuals at risk of developing T2DM and in explaining disease pathogenesis. Adiponectin is secreted by fat cells and is linked with insulin resistance. Adiponectin levels are dysregulated in prediabetic subjects. This relationship had not been tested in Jordan. We recruited 130 subjects with prediabetes and 130 control subjects. We measured serum levels of adiponectin and genotyped subjects for three single nucleotide polymorphisms (SNPs) in the ADIPOQ gene; rs266729, rs1501299 and rs2241766. In multivariate analysis, we found that serum adiponectin lowers the risk of prediabetes (p = 0.002; odds ratio (OR), 0.764; 95% confidence interval (CI), 0.646–0.905). The rs1501299 SNP of the ADIPOQ gene was associated with prediabetes in our population (p = 0.041). Specifically, in multivariate analysis, the GT genotype of rs1501299 increased the risk of prediabetes (p = 0.010; OR, 2.350; 95% CI, 1.231–4.486) as well as the TT genotype (p = 0.006; OR, 4.774; 95% CI, 1.551–14.693). Our findings indicate that serum adiponectin and SNPs in the ADIPOQ gene are associated with prediabetes in Jordan. View Full-Text
Keywords: diabetes mellitus; prediabetes; insulin resistance; adiponectin; ADIPOQ; single nucleotide polymorphisms; rs1501299 diabetes mellitus; prediabetes; insulin resistance; adiponectin; ADIPOQ; single nucleotide polymorphisms; rs1501299
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Alfaqih, M.A.; Al-Mughales, F.; Al-Shboul, O.; Al Qudah, M.; Khader, Y.S.; Al-Jarrah, M. Association of Adiponectin and rs1501299 of the ADIPOQ Gene with Prediabetes in Jordan. Biomolecules 2018, 8, 117.

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