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Biomolecules 2018, 8(3), 47; https://doi.org/10.3390/biom8030047

Genetics of Lipodystrophy: Can It Help in Understanding the Pathophysiology of Metabolic Syndrome?

1
Sawai Man Singh Medical College and Hospital, JLN Marg, Jaipur 302004, India
2
Department of Biotechnology and Bioinformatics, Birla Institute of Scientific Research, Statue Circle, Jaipur 302001, India
3
Department of Biotechnology, IIS University, Mansarovar, Jaipur 302020, India
4
Department of Biotechnology, Central University of Rajasthan, Bandarsindri, N.H. 8, Kishangarh 305801, India
*
Authors to whom correspondence should be addressed.
Received: 24 May 2018 / Revised: 21 June 2018 / Accepted: 22 June 2018 / Published: 6 July 2018
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Abstract

Understanding phenotypes and their genetic determinants for metabolic syndrome (MetS) has been quite challenging. With the advent of systems genomic approaches, there is a need to decipher methods for identification and evaluating the functional role of phenotypic traits associated with complex diseases, such as MetS. The monogenic syndromes of lipodystrophy are well understood, but the molecular pathophysiology of insulin resistance (IR) underpinning the obesity, diabetes mellitus, and dyslipidemia is not well deciphered. In this commentary, we argue the role of pathophysiology of MetS, and its effects into possible understanding of genetic determinants associated with lipodystrophy-mediated diabetes mellitus. View Full-Text
Keywords: lipodystrophy; metabolic syndrome; type-2 diabetes mellitus; obesity; regulation; functional genomics; systems biology; phenotypic traits; insulin resistance lipodystrophy; metabolic syndrome; type-2 diabetes mellitus; obesity; regulation; functional genomics; systems biology; phenotypic traits; insulin resistance
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Mathur, S.K.; Tiwari, P.; Gupta, S.; Gupta, N.; Nimesh, S.; Medicherla, K.M.; Suravajhala, P. Genetics of Lipodystrophy: Can It Help in Understanding the Pathophysiology of Metabolic Syndrome? Biomolecules 2018, 8, 47.

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