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Dietary Fatty Acids and Microbiota-Brain Communication in Neuropsychiatric Diseases

1
European Brain Research Institute (EBRI), Fondazione Rita Levi-Montalcini, 00161 Rome, Italy
2
National Research Council (CNR), Institute for Complex System (ISC), 00185 Rome, Italy
3
IRCCS–S. Lucia Foundation (FSL), 00143 Rome, Italy
*
Author to whom correspondence should be addressed.
Biomolecules 2020, 10(1), 12; https://doi.org/10.3390/biom10010012
Received: 15 October 2019 / Revised: 16 December 2019 / Accepted: 17 December 2019 / Published: 19 December 2019
(This article belongs to the Special Issue Bioactive Lipids in Health and Disease)
The gut-brain axis is a multimodal communication system along which immune, metabolic, autonomic, endocrine and enteric nervous signals can shape host physiology and determine liability, development and progression of a vast number of human diseases. Here, we broadly discussed the current knowledge about the either beneficial or deleterious impact of dietary fatty acids on microbiota-brain communication (MBC), and the multiple mechanisms by which different types of lipids can modify gut microbial ecosystem and contribute to the pathophysiology of major neuropsychiatric diseases (NPDs), such as schizophrenia (SCZ), depression and autism spectrum disorders (ASD). View Full-Text
Keywords: microbiota-brain communication; dietary fatty acids; polyunsaturated fatty acids; depression; schizophrenia microbiota-brain communication; dietary fatty acids; polyunsaturated fatty acids; depression; schizophrenia
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Marrone, M.C.; Coccurello, R. Dietary Fatty Acids and Microbiota-Brain Communication in Neuropsychiatric Diseases. Biomolecules 2020, 10, 12.

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