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Metabolites, Volume 2, Issue 2

2012 June - 4 articles

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Articles (4)

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Article

8 Citations

8,297 Views

16 Pages

Metabolomic and Lipidomic Analysis of the Heart of Peroxisome Proliferator-Activated Receptor-γ Coactivator 1-β Knock Out Mice on a High Fat Diet

Gregor McCombie,
Gema Medina-Gomez,
Christopher J Lelliott,
Antonio Vidal-Puig and
Julian L Griffin

Metabolites2012, 2(2), 366-381;https://doi.org/10.3390/metabo2020366

18 June 2012

The peroxisome proliferator-activated receptor-γ coactivators (PGC-1) are transcriptional coactivators with an important role in mitochondrial biogenesis and regulation of genes involved in the electron transport chain and oxidative phosphorylation i...

Full Article

Review

36 Citations

12,089 Views

29 Pages

Targeted Chiral Analysis of Bioactive Arachidonic Acid Metabolites Using Liquid-Chromatography-Mass Spectrometry

Clementina Mesaros and
Ian A. Blair

Metabolites2012, 2(2), 337-365;https://doi.org/10.3390/metabo2020337

20 April 2012

A complex structurally diverse series of eicosanoids arises from the metabolism of arachidonic acid. The metabolic profile is further complicated by the enantioselectivity of eicosanoid formation and the variety of regioisomers that arise. In order t...

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Review

1,604 Citations

71,574 Views

34 Pages

A Historical Overview of Natural Products in Drug Discovery

Daniel A. Dias,
Sylvia Urban and
Ute Roessner

Metabolites2012, 2(2), 303-336;https://doi.org/10.3390/metabo2020303

16 April 2012

Historically, natural products have been used since ancient times and in folklore for the treatment of many diseases and illnesses. Classical natural product chemistry methodologies enabled a vast array of bioactive secondary metabolites from terrest...

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Review

53 Citations

14,419 Views

11 Pages

5-Aminoimidazole-4-carboxamide-1-beta-D-ribofuranosyl 5'-Monophosphate (AICAR), a Highly Conserved Purine Intermediate with Multiple Effects

Bertrand Daignan-Fornier and
Benoît Pinson

Metabolites2012, 2(2), 292-302;https://doi.org/10.3390/metabo2020292

23 March 2012

AICAR (5-Aminoimidazole-4-carboxamide-1-beta-D-ribofuranosyl 5'-monophosphate) is a natural metabolic intermediate of purine biosynthesis that is present in all organisms. In yeast, AICAR plays important regulatory roles under physiological condition...

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