Screening of Panamanian Plants for Cosmetic Properties, and HPLC-Based Identification of Constituents with Antioxidant and UV-B Protecting Activities

Niels GULDBRANDSEN; Maria DE MIERI; Mahabir GUPTA; Eleni LIAKOU; Harris PRATSINIS; Dimitris KLETSAS; Eliza CHAITA; Nektarios ALIGIANNIS; Alexios-Leandros SKALTSOUNIS; Matthias HAMBURGER

doi:10.3797/scipharm.1409-12

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Scientia Pharmaceutica is published by MDPI from Volume 84 Issue 3 (2016). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Austrian Pharmaceutical Society (Österreichische Pharmazeutische Gesellschaft, ÖPhG).

Article

15 October 2014

Screening of Panamanian Plants for Cosmetic Properties, and HPLC-Based Identification of Constituents with Antioxidant and UV-B Protecting Activities

and

Division of Pharmaceutical Biology, University of Basel, Klingelbergstrasse 40, CH-4056 Basel, Switzerland

CIFLORPAN, College of Pharmacy, University of Panama, Apartado 0824-00172, Panama, Republic of Panama

Laboratory of Cell Proliferation & Ageing, Institute of Biosciences & Applications, NCSR “Demokritos”, 15310, Athens, Greece

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Korres S.A. Natural Products, 57th Athens-Lamia National Road, 32011, Inofyta, Greece

Sci. Pharm.2015, 83(1), 177-190;https://doi.org/10.3797/scipharm.1409-12

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Abstract

A library of 600 taxonomically diverse Panamanian plant extracts was screened for DPPH scavenging and UV-B protective activities, and the methanolic extracts of Mosquitoxylum jamaicense, Combretum cacoucia, and Casearia commersionia were submitted to HPLC-based activity profiling. The compounds located in the active time windows were isolated and identified as gallic acid derivatives and flavonoids. Gallic acid methyl ester (3) and digallic acid derivatives (2, 6) showed the highest DPPH scavenging activity (<10 μg/mL), while protocatechuic acid (7) and isoquercitrin (10) exhibited the highest UV-B protective properties.

Keywords:

Panamanian plant extract; HPLC-based activity profiling; DPPH scavenging; UV-B protection

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