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Sci. Pharm.
Volume 83
Issue 1
10.3797/scipharm.1406-19
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Scientia Pharmaceutica is published by MDPI from Volume 84 Issue 3 (2016). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Austrian Pharmaceutical Society (Österreichische Pharmazeutische Gesellschaft, ÖPhG).
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Article

Enhancing Skin Permeation of Biphenylacetic Acid (BPA) Using Salt Formation with Organic and Alkali Metal Bases

by
Vijay PAWAR
,
Prashant NAIK
,
Rajani GIRIDHAR
and
Mange Ram YADAV
*
Pharmacy Department, Faculty of Technology & Engineering, The M. S. University of Baroda, Vadodara-390001, India
*
Author to whom correspondence should be addressed.
Sci. Pharm. 2015, 83(1), 191-205; https://doi.org/10.3797/scipharm.1406-19
Submission received: 30 June 2014 / Accepted: 26 September 2014 / Published: 26 September 2014
Versions Notes

Abstract

In the present study, a series of organic and alkali metal salts of biphenylacetic acid (BPA) have been prepared and evaluated in vitro for percutaneous drug delivery. The physicochemical properties of BPA salts were determined using solubility measurements, DSC, and IR. The DSC thermogram and FTIR spectra confirmed the salt formation with organic and alkali metal bases. Among the series, salts with organic amines (ethanolamine, diethanolamine, triethanol-amine, and diethylamine) had lowered melting points while the alkali metal salt (sodium) had a higher melting point than BPA. The in vitro study showed that salt formation improves the physicochemical properties of BPA, leading to improved permeability through the skin. Amongst all the prepared salts, ethanolamine salt (1b) showed 7.2- and 5.4-fold higher skin permeation than the parent drug at pH 7.4 and 5.0, respectively, using rat skin.
Keywords: BPA; Lipophilicity; NSAID; Salt; Skin permeation BPA; Lipophilicity; NSAID; Salt; Skin permeation

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MDPI and ACS Style

PAWAR, V.; NAIK, P.; GIRIDHAR, R.; YADAV, M.R. Enhancing Skin Permeation of Biphenylacetic Acid (BPA) Using Salt Formation with Organic and Alkali Metal Bases. Sci. Pharm. 2015, 83, 191-205. https://doi.org/10.3797/scipharm.1406-19

AMA Style

PAWAR V, NAIK P, GIRIDHAR R, YADAV MR. Enhancing Skin Permeation of Biphenylacetic Acid (BPA) Using Salt Formation with Organic and Alkali Metal Bases. Scientia Pharmaceutica. 2015; 83(1):191-205. https://doi.org/10.3797/scipharm.1406-19

Chicago/Turabian Style

PAWAR, Vijay, Prashant NAIK, Rajani GIRIDHAR, and Mange Ram YADAV. 2015. "Enhancing Skin Permeation of Biphenylacetic Acid (BPA) Using Salt Formation with Organic and Alkali Metal Bases" Scientia Pharmaceutica 83, no. 1: 191-205. https://doi.org/10.3797/scipharm.1406-19

APA Style

PAWAR, V., NAIK, P., GIRIDHAR, R., & YADAV, M. R. (2015). Enhancing Skin Permeation of Biphenylacetic Acid (BPA) Using Salt Formation with Organic and Alkali Metal Bases. Scientia Pharmaceutica, 83(1), 191-205. https://doi.org/10.3797/scipharm.1406-19

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