Next Article in Journal
Evaluation of the Anticonvulsant and Anxiolytic Potentials of Methyl Jasmonate in Mice
Previous Article in Journal
Ameliorative Effects of a Polyphenolic Fraction of Cinnamomum zeylanicum L. Bark in Animal Models of Inflammation and Arthritis
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
Sci. Pharm.
Volume 82
Issue 3
10.3797/scipharm.1406-01
scipharm-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles thumb_up
...
Endorse textsms
...
Comment
Scientia Pharmaceutica is published by MDPI from Volume 84 Issue 3 (2016). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Austrian Pharmaceutical Society (Österreichische Pharmazeutische Gesellschaft, ÖPhG).
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Article

Lack of Association between the Serotonin Transporter (5-HTT) and Serotonin Receptor (5-HT2A) Gene Polymorphisms with Smoking Behavior among Malaysian Malays

by
Nur Iwani A. ROZAK
1,
Imran AHMAD
2,
Siew Hua GAN
3 and
Ruzilawati ABU BAKAR
1,*
1
Department of Pharmacology, School of Medical Sciences, Universiti Sains Malaysia, Kelantan, Malaysia
2
Department of Family Medicine, School of Medical Sciences, Universiti Sains Malaysia, Kelantan, Malaysia
3
Human Genome Centre, School of Medical Sciences, Universiti Sains Malaysia, Kelantan, Malaysia
*
Author to whom correspondence should be addressed.
Sci. Pharm. 2014, 82(3), 631-642; https://doi.org/10.3797/scipharm.1406-01
Submission received: 2 June 2014 / Accepted: 18 July 2014 / Published: 18 July 2014
Versions Notes

Abstract

An insertion/deletion polymorphism in the promoter region of the serotonin transporter gene (5-HTTLPR) and a polymorphism (rs6313) in the serotonin 2A receptor gene (5-HT2A) have previously been linked to smoking behavior. The objective of this study was to determine the possible association of the 5-HTTLPR and 5-HT2A gene polymorphisms with smoking behavior within a population of Malaysian male smokers (n=248) and non-smokers (n=248). The 5-HTTLPR genotypes were determined using the polymerase chain reaction (PCR) and were classified as short (S) alleles or long (L) alleles. The 5HT2A genotypes were determined using PCR–restriction fragment length polymorphisms (PCR-RFLP). No significant differences in the distribution frequencies of the alleles were found between the smokers and the non-smokers for the 5-HTTLPR polymorphism (χ2 = 0.72, P>0.05) or the 5HT2A polymorphism (χ2 = 0.73, P>0.05). This is the first study conducted on Malaysian Malay males regarding the association of 5-HTTLPR and 5HT2A polymorphisms and smoking behavior. However, the genes were not found to be associated with smoking behavior in our population.
Keywords: 5-HTTLPR; 5HT2A; Genetic polymorphism; PCR-RFLP; Malaysian Malays male 5-HTTLPR; 5HT2A; Genetic polymorphism; PCR-RFLP; Malaysian Malays male

Share and Cite

MDPI and ACS Style

ROZAK, N.I.A.; AHMAD, I.; GAN, S.H.; BAKAR, R.A. Lack of Association between the Serotonin Transporter (5-HTT) and Serotonin Receptor (5-HT2A) Gene Polymorphisms with Smoking Behavior among Malaysian Malays. Sci. Pharm. 2014, 82, 631-642. https://doi.org/10.3797/scipharm.1406-01

AMA Style

ROZAK NIA, AHMAD I, GAN SH, BAKAR RA. Lack of Association between the Serotonin Transporter (5-HTT) and Serotonin Receptor (5-HT2A) Gene Polymorphisms with Smoking Behavior among Malaysian Malays. Scientia Pharmaceutica. 2014; 82(3):631-642. https://doi.org/10.3797/scipharm.1406-01

Chicago/Turabian Style

ROZAK, Nur Iwani A., Imran AHMAD, Siew Hua GAN, and Ruzilawati ABU BAKAR. 2014. "Lack of Association between the Serotonin Transporter (5-HTT) and Serotonin Receptor (5-HT2A) Gene Polymorphisms with Smoking Behavior among Malaysian Malays" Scientia Pharmaceutica 82, no. 3: 631-642. https://doi.org/10.3797/scipharm.1406-01

APA Style

ROZAK, N. I. A., AHMAD, I., GAN, S. H., & BAKAR, R. A. (2014). Lack of Association between the Serotonin Transporter (5-HTT) and Serotonin Receptor (5-HT2A) Gene Polymorphisms with Smoking Behavior among Malaysian Malays. Scientia Pharmaceutica, 82(3), 631-642. https://doi.org/10.3797/scipharm.1406-01

Article Metrics

Back to TopTop