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Volume 81
Issue 2
10.3797/scipharm.1210-15
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Scientia Pharmaceutica is published by MDPI from Volume 84 Issue 3 (2016). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Austrian Pharmaceutical Society (Österreichische Pharmazeutische Gesellschaft, ÖPhG).
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Article

Analysis of the Cytotoxic Potential of Anisomelic Acid Isolated from Anisomeles malabarica

by
Christo Paul PREETHY
1,
Ali Abdullah ALSHATWI
2,
Muthukumaran GUNASEKARAN
3 and
Mohammad Abdulkadher AKBARSHA
2,4,*
1
Department of Animal Science, Bharathidasan University, Tiruchirappalli 620024, India
2
Department of Food Science and Nutrition, King Saud University, Riyadh 11451, Saudi Arabia
3
Department of Biology, Fisk University, Nashville, TN 37208, USA
4
Mahatma Gandhi-Doerenkamp Center, Bharathidasan University, Tiruchirappalli 620024, India
*
Author to whom correspondence should be addressed.
Sci. Pharm. 2013, 81(2), 559-566; https://doi.org/10.3797/scipharm.1210-15
Submission received: 18 October 2012 / Accepted: 25 January 2013 / Published: 25 January 2013
Versions Notes

Abstract

Anisomelic acid (AA), one of the major compounds in Anisomeles malabarica, was tested for its cytotoxicity and apoptosis-inducing potential in breast and cervical cancer cells. The MTT assay for cell viability indicated that AA is cytotoxic to all of the four cell lines tested in a dose- and duration-dependent manner. Acridine Orange & Ethidium Bromide (AO & EB) and Hoechst 33258 staining of AA-treated cells revealed typical apoptotic morphology such as condensed chromatin and formation of apoptotic bodies. The comet assay revealed DNA strand break(s), indicating that AA induces DNA damage which culminates in apoptosis. Thus, the study revealed the anti-proliferative and apoptosis-inducing properties of AA in both breast and cervical cancer cells. Therefore, anisomelic acid offers potential for application in breast and cervical cancer therapy.
Keywords: Anisomeles malabarica; Anisomelic acid; Apoptosis; Cytotoxicity; Anti-cancer Anisomeles malabarica; Anisomelic acid; Apoptosis; Cytotoxicity; Anti-cancer

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MDPI and ACS Style

PREETHY, C.P.; ALSHATWI, A.A.; GUNASEKARAN, M.; AKBARSHA, M.A. Analysis of the Cytotoxic Potential of Anisomelic Acid Isolated from Anisomeles malabarica. Sci. Pharm. 2013, 81, 559-566. https://doi.org/10.3797/scipharm.1210-15

AMA Style

PREETHY CP, ALSHATWI AA, GUNASEKARAN M, AKBARSHA MA. Analysis of the Cytotoxic Potential of Anisomelic Acid Isolated from Anisomeles malabarica. Scientia Pharmaceutica. 2013; 81(2):559-566. https://doi.org/10.3797/scipharm.1210-15

Chicago/Turabian Style

PREETHY, Christo Paul, Ali Abdullah ALSHATWI, Muthukumaran GUNASEKARAN, and Mohammad Abdulkadher AKBARSHA. 2013. "Analysis of the Cytotoxic Potential of Anisomelic Acid Isolated from Anisomeles malabarica" Scientia Pharmaceutica 81, no. 2: 559-566. https://doi.org/10.3797/scipharm.1210-15

APA Style

PREETHY, C. P., ALSHATWI, A. A., GUNASEKARAN, M., & AKBARSHA, M. A. (2013). Analysis of the Cytotoxic Potential of Anisomelic Acid Isolated from Anisomeles malabarica. Scientia Pharmaceutica, 81(2), 559-566. https://doi.org/10.3797/scipharm.1210-15

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