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Scientia Pharmaceutica is published by MDPI from Volume 84 Issue 3 (2016). Articles in this Issue were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence. Articles are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Austrian Pharmaceutical Society (Österreichische Pharmazeutische Gesellschaft, ÖPhG).
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Sci. Pharm. 2013, 81(2), 559-566; https://doi.org/10.3797/scipharm.1210-15

Analysis of the Cytotoxic Potential of Anisomelic Acid Isolated from Anisomeles malabarica

1
Department of Animal Science, Bharathidasan University, Tiruchirappalli 620024, India
2
Department of Food Science and Nutrition, King Saud University, Riyadh 11451, Saudi Arabia
3
Department of Biology, Fisk University, Nashville, TN 37208, USA
4
Mahatma Gandhi-Doerenkamp Center, Bharathidasan University, Tiruchirappalli 620024, India
*
Author to whom correspondence should be addressed.
Received: 18 October 2012 / Accepted: 25 January 2013 / Published: 25 January 2013
PDF [234 KB, uploaded 28 September 2016]

Abstract

Anisomelic acid (AA), one of the major compounds in Anisomeles malabarica, was tested for its cytotoxicity and apoptosis-inducing potential in breast and cervical cancer cells. The MTT assay for cell viability indicated that AA is cytotoxic to all of the four cell lines tested in a dose- and duration-dependent manner. Acridine Orange & Ethidium Bromide (AO & EB) and Hoechst 33258 staining of AA-treated cells revealed typical apoptotic morphology such as condensed chromatin and formation of apoptotic bodies. The comet assay revealed DNA strand break(s), indicating that AA induces DNA damage which culminates in apoptosis. Thus, the study revealed the anti-proliferative and apoptosis-inducing properties of AA in both breast and cervical cancer cells. Therefore, anisomelic acid offers potential for application in breast and cervical cancer therapy.
Keywords: Anisomeles malabarica; Anisomelic acid; Apoptosis; Cytotoxicity; Anti-cancer Anisomeles malabarica; Anisomelic acid; Apoptosis; Cytotoxicity; Anti-cancer
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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PREETHY, C.P.; ALSHATWI, A.A.; GUNASEKARAN, M.; AKBARSHA, M.A. Analysis of the Cytotoxic Potential of Anisomelic Acid Isolated from Anisomeles malabarica. Sci. Pharm. 2013, 81, 559-566.

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