Quinazolinobenzodiazepine Derivatives, Novobenzomalvins A–C: Fibronectin Expression Regulators from Aspergillus novofumigatus

Kazuki ISHIKAWA; Tomoo HOSOE; Takeshi ITABASHI; Fumiaki SATO; Hiroshi WACHI; Hiromasa NAGASE; Takashi YAGUCHI; Ken-Ichi KAWAI

doi:10.3797/scipharm.1106-21

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Article

3 October 2011

Quinazolinobenzodiazepine Derivatives, Novobenzomalvins A–C: Fibronectin Expression Regulators from Aspergillus novofumigatus

and

Faculty of Pharmaceutical Sciences, Hoshi University, 2-4-41 Ebara, Shinagawa-ku, Tokyo 142-8501, Japan

Medical Mycology Research Center, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba 260-8673, Japan

Author to whom correspondence should be addressed.

Sci. Pharm.2011, 79(4), 937-950;https://doi.org/10.3797/scipharm.1106-21

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Abstract

Three new quinazolinobenzodiazepine derivatives, novobenzomalvins A (1), B (2), and C (3), have been isolated as fibronectin expression regulators from Aspergillus novofumigatus CBS117520. The structures of 1 to 3 were established by spectroscopic and physicochemical analysis, and chemical investigation including the total synthesis of 1. Treatment with novo-benzomalvins A (1), B (2), C (3), and N-methylnovobenzomalvin A (5) increased the expression of fibronectin in normal human neonatal dermal fibroblast cells.

Keywords:

Aspergillus novofumigatus; Novobenzomalvin; Quinazolinobenzodiazepine; Fibronectin expression regulator; Alkaloids; X-ray crystallography

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